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Olanzapine, Fluoxetine Hydrochloride Oral capsule

It is used to treat episodes of depression that have not been relieved by the use of other medicines... more

Generic Name: fluoxetine-olanzapine

Brand Names: Symbyax

What is this medicine?

FLUOXETINE; OLANZAPINE (floo OX e teen; oh LAN za peen) is used to treat episodes of depression that have not been relieved by the use of other medicines and depression caused by bipolar disorder.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • Alzheimer's disease or dementia
  • bleeding disorders
  • diabetes
  • glaucoma
  • heart disease, irregular heartbeat, or previous heart attack
  • high blood pressure treated with medication
  • kidney disease
  • liver disease
  • low blood pressure
  • low levels of potassium or magnesium in the blood
  • Parkinson's disease
  • receiving electroconvulsive therapy
  • strokes, or mini-strokes called transient ischemic attacks (TIAs)
  • suicidal thoughts, plans, or attempt; a previous suicide attempt by you or a family member
  • an unusual or allergic reaction to fluoxetine, olanzapine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take this medicine with or without food. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 10 years of age for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • other medicines containing fluoxetine or olanzapine, such as Prozac, Sarafem, or Zyprexa
  • cisapride
  • dofetilide
  • dronedarone
  • linezolid
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • methylene blue (injected into a vein)
  • metoclopramide
  • pimozide
  • thioridazine
  • ziprasidone

This medicine may also interact with the following medications:

  • alcohol
  • aspirin or aspirin-like medicines
  • carbamazepine
  • certain medicines for depression, anxiety, or psychotic disturbances
  • certain medicines for migraine headaches like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
  • digoxin
  • diuretics
  • fentanyl
  • flecainide
  • furazolidone
  • isoniazid
  • lithium
  • medicines for high blood pressure
  • medicines for Parkinson's disease
  • medicines for sleep
  • medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • omeprazole
  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)
  • phenytoin
  • procarbazine
  • propafenone
  • rifampin
  • ritonavir
  • supplements like St. John's wort, kava kava, valerian
  • tramadol
  • tryptophan
  • vinblastine


Last Updated: August 13, 2013
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