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Fluoxetine Hydrochloride Oral capsule, gastro-resistant pellets, weekly [Depression/Mood Disorders]

The weekly capsules can treat mood problems such as depression

Generic Name: fluoxetine  |  Brand Name: Selfemra

Brand Names: Sarafem, Rapiflux, Prozac, Selfemra, Prozac Weekly

There is an FDA Alert for this drug. Click here to view it.

What is this medicine?

FLUOXETINE (floo OX e teen) belongs to a class of drugs known as selective serotonin reuptake inhibitors (SSRIs). The weekly capsules can treat mood problems such as depression.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • bipolar disorder or mania
  • diabetes
  • glaucoma
  • liver disease
  • psychosis
  • seizures
  • suicidal thoughts or history of attempted suicide
  • an unusual or allergic reaction to fluoxetine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush, or chew this medicine. You can take this medicine with or without food. Take it on the same day of the week each week. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

Try not to miss your scheduled weekly dose. You may want to mark a calendar to remind you. If you miss a dose, and it is still the day you normally take your medicine each week, then take it as soon as you can. If it is another day, then take the dose as soon as you remember and then adjust your weekly doses to the new day of the week. Do not take double or extra doses. There should be one week between each dose.

What may interact with this medicine?

Do not take fluoxetine with any of the following medications:
  • other medicines containing fluoxetine, like Sarafem or Symbyax
  • cisapride
  • linezolid
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • methylene blue (injected into a vein)
  • pimozide
  • thioridazine

Fluoxetine may also interact with the following medications:

  • alcohol
  • aspirin and aspirin-like medicines
  • carbamazepine
  • certain medicines for depression, anxiety, or psychotic disturbances
  • certain medicines for migraine headaches like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
  • digoxin
  • diuretics
  • fentanyl
  • flecainide
  • furazolidone
  • isoniazid
  • lithium
  • medicines for sleep
  • medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • phenytoin
  • procarbazine
  • propafenone
  • rasagiline
  • ritonavir
  • supplements like St. John's wort. kava kava, valerian
  • tramadol
  • tryptophan
  • vinblastine


Last Updated: May 03, 2013
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