Drugs A - Z

Ibuprofen, Famotidine Oral tablet

Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID)

Generic Name: ibuprofen

There is an FDA Alert for this drug. Click here to view it.

    Cardiovascular Risk
  • Possible increased risk of serious (sometimes fatal) cardiovascular thrombotic events (e.g., MI, stroke). Risk may increase with duration of use. Individuals with cardiovascular disease or risk factors for cardiovascular disease may be at increased risk. (See Cardiovascular Effects under Cautions.)
  • Contraindicated for the treatment of pain in the setting of CABG surgery.

    GI Risk
  • Increased risk of serious (sometimes fatal) GI events (e.g., bleeding, ulceration, perforation of the stomach or intestine). Serious GI events can occur at any time and may not be preceded by warning signs and symptoms. Geriatric individuals are at greater risk for serious GI events. (See GI Effects under Cautions.)

What is this medicine?

FAMOTIDINE; IBUPROFEN (fa MOE ti deen; eye BYOO proe fen) is two medicines together. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID). It is used for arthritis pain. Famotidine is a type of antihistamine that blocks the release of stomach acid. It is used to prevent stomach problems from the ibuprofen.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • asthma
  • cigarette smoker
  • drink more than 3 alcohol containing drinks a day
  • heart disease
  • high blood pressure
  • history of stomach bleeding
  • kidney disease
  • liver disease
  • stomach or intestine problems
  • an unusual or allergic reaction to famotidine, ibuprofen, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not cut, crush or chew this medicine. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • cidofovir
  • ketorolac
  • methotrexate

This medicine may also interact with the following medications:

  • alcohol
  • aspirin
  • certain medicines for blood pressure, heart disease, irregular heart beat
  • certain medicines for depression, anxiety, or psychotic disturbances
  • cholestyramine
  • diuretics
  • lithium
  • steroid medicines like prednisone or cortisone
  • supplements like feverfew, flavocoxid, garlic, ginger, ginkgo, and methylsulfonylmethane, MSM
  • warfarin

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

Do not take other medicines that contain aspirin, ibuprofen, or naproxen with this medicine. Side effects such as stomach upset, nausea, or ulcers may be more likely to occur. Many medicines available without a prescription should not be taken with this medicine.

This medicine can cause ulcers and bleeding in the stomach and intestines at any time during treatment. This can happen with no warning and may cause death. There is increased risk with taking this medicine for a long time. Smoking, drinking alcohol, older age, and poor health can also increase risks. Call your doctor right away if you have stomach pain or blood in your vomit or stool.

This medicine does not prevent heart attack or stroke. In fact, this medicine may increase the chance of a heart attack or stroke. The chance may increase with longer use of this medicine and in people who have heart disease. If you take aspirin to prevent heart attack or stroke, talk with your doctor or health care professional.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.


Last Updated: June 10, 2011
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