Ethacrynate Sodium Solution for injection

What is this medicine?

ETHACRYNIC ACID (eth a KRIN ik AS id) is a diuretic. It helps you make more urine and to lose salt and excess water from your body. This medicine is used to treat edema, heart failure, or water retention.

This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

• abnormal blood electrolytes
• diarrhea or vomiting
• gout
• hearing problems
• heart disease
• kidney disease, small amounts of urine, or difficulty passing urine
• liver disease
• an unusual or allergic reaction to ethacrynic acid, other medicines, foods, dyes, or preservatives
• pregnant or trying to get pregnant
• breast-feeding

How should I use this medicine?

This medicine is injected into a vein. It is usually given by a health care professional in a hospital or a clinic.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

• antiinflammatory drugs like indomethacin
• certain antibiotics given by injection
• diuretics
• heart medicines like digoxin
• hormones like cortisone, fludrocortisone, or hydrocortisone
• lithium
• medicines for diabetes
• medicines for high blood pressure
• warfarin

This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.

What should I watch for while using this medicine?

You will be closely monitored while taking this medicine. It will lower your blood pressure and may increase your blood sugar. If you are diabetic your sugar will need to be checked.

This medication can make you feel confused, dizzy or lightheaded. Drinking alcohol can make this worse. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not sit or stand up quickly.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

• allergic reactions such as skin rash or itching, hives, swelling of the lips, mouth, tongue, or throat
• blood in the urine or stools
• blurred vision
• dry mouth
• fever or chills
• hearing loss, ringing in the ears
• irregular heartbeat
• muscle cramps, pain or weakness
• unusually weak or tired
• vomiting or diarrhea

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

• headache
• loss of appetite
• stomach upset, pain or nausea
• unusual bleeding or bruising

This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Where should I keep my medicine?

Keep out of the reach of children.

Store vials at room temperature (59 and 86 degrees F). After mixing the injection solution use within 24 hours. Do not use if the solution is hazy or cloudy. Throw away any unused injection solution.

NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.