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Esomeprazole Magnesium, Naproxen Oral tablet, delayed-release

Naproxen is a non-steroidal anti-inflammatory drug (NSAID)

Generic Name: Vimovo

What is this medicine?

ESOMEPRAZOLE; NAPROXEN (es oh ME pray zol; na PROX en) is two medicines together. Naproxen is a non-steroidal anti-inflammatory drug (NSAID). It is used to treat the pain of arthritis. Esomeprazole is a proton pump inhibitor (PPI). It is used to prevent stomach problems from the naproxen.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • asthma
  • cigarette smoker
  • drink more than 3 alcohol containing beverages a day
  • heart disease or circulation problems such as heart failure or leg edema (fluid retention)
  • high blood pressure
  • kidney disease
  • liver disease
  • low levels of magnesium in the blood
  • stomach bleeding or ulcers
  • an unusual or allergic reaction to naproxen, aspirin, other NSAIDs, esomeprazole or other proton pump inhibitors, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Do not crush, chew, split, or dissolve. Take this medicine on an empty stomach at least 30 minutes before a meal. Take your medicine at regular intervals. Do not take it more often than directed. Long term, continuous use may increase the risk of heart attack or stroke.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • atazanavir
  • nelfinavir

This medicine may also interact with the following medications:

  • alcohol
  • aspirin and aspirin-like medicines
  • cholestyramine
  • cidofovir
  • delavirdine
  • digoxin
  • diuretics
  • fosphenytoin or phenytoin for seizures
  • iron salts
  • lithium
  • medicines for blood pressure
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for fungal infections like ketoconazole and itraconazole
  • medicines for stomach, or intestine problems, like acid reflux or GERD
  • medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin
  • methotrexate
  • other NSAIDs, medicines for pain and inflammation, like ibuprofen
  • pemetrexed
  • probenecid
  • rifampin
  • steroid medicines like prednisone or cortisone
  • sucralfate
  • sulfonamides
  • sulfonylureas
  • St. John's Wort


Last Updated: December 06, 2011
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