Drugs A - Z

Drospirenone, Ethinyl Estradiol, Levomefolate Calcium Oral tablet

This medicine combines two types of female hormones, an estrogen and a progestin

Generic Name: Safyral

What is this medicine?

DROSPIRENONE; ETHINYL ESTRADIOL; LEVOMEFOLATE (dro SPY re nown; ETH in il es tra DYE ole; lee voe ME FOE late) is an oral contraceptive (birth control pill). This medicine combines two types of female hormones, an estrogen and a progestin. This medicine also has levomefolate, a B vitamin. It is used to prevent ovulation and pregnancy. It is also used to treat the symptoms of premenstrual dysphoric disorder (PMDD), to treat acne, and to raise folate levels in women who want to use birth control.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

-abnormal vaginal bleeding
-adrenal gland disease
-blood vessel disease or blood clots
-breast, cervical, endometrial, ovarian, liver, or uterine cancer
-depression
-diabetes
-gallbladder disease
-heart disease or recent heart attack
-high blood pressure
-high cholesterol
-high potassium level
-kidney disease
-liver disease
-migraine headaches
-stroke
-systemic lupus erythematosus (SLE)
-thyroid disease
-tobacco smoker
-an unusual or allergic reaction to estrogens, progestins, folates, or other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

How should I use this medicine?

Take this medicine by mouth. To reduce nausea, this medicine may be taken with food. Follow the directions on the prescription label. Take this medicine at the same time each day and in the order directed on the package. Do not take your medicine more often than directed.

A patient package insert for the product will be given with each prescription and refill. Read this sheet carefully each time. The sheet may change frequently.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. This medicine has been used in female children who have started having menstrual periods.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, refer to the patient information sheet you received with your medicine for direction. If you miss more than one pill, this medicine may not be as effective and you may need to use another form of birth control.

What may interact with this medicine?

Do not take this medicine with any of the following medications:

-aminoglutethimide
-amprenavir, fosamprenavir
-anastrozole
-bosentan
-exemestane
-letrozole
-metyrapone
-testolactone

This medicine may also interact with the following medications:

-acetaminophen
-antiviral medicines for HIV or AIDS
-atorvastatin
-barbiturates
-certain antibiotics like rifampin, rifabutin, rifapentine, and griseofulvin, and possibly penicillins or tetracyclines
-certain medicines for fungal infections like ketoconazole and itraconazole
-certain medicines for seizures like carbamazepine, phenobarbital, phenytoin
-cholestyramine
-felbamate
-lamotrigine
-methotrexate
-phenytoin
-pyrimethamine
-sulfasalazine
-St. John's wort
-topiramate
This product is different from other birth control pills because it contains the progestin drospirenone. Drospirenone may increase potassium levels. Interactions with other drugs may increase the chance of an elevated potassium level. You may need blood tests to check your potassium level. Drugs that can increase the potassium level include:

-certain medicines for blood pressure or heart disease like enalapril, losartan, eplerenone
-dietary salt substitutes (these may contain potassium)
-diuretics
-heparin
-NSAIDS, medicines for pain and inflammation, like ibuprofen or naproxen
-potassium supplements


Last Updated: January 25, 2011
Licensed from
The Healthline Site, its content, such as text, graphics, images, search results, HealthMaps, Trust Marks, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.
Advertisement