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Droperidol Solution for injection

It is used to prevent nausea and vomiting associated with surgery or other procedures.

Generic Name: droperidol  |  Brand Name: Inapsine

Brand Names: Inapsine

There is an FDA Alert for this drug. Click here to view it.

    QT Interval Prolongation
  • QT interval prolongation and/or torsades de pointes (including fatalities) have occurred at doses at or below those recommended, in some cases when no known risk factors were present.
  • Because of potential for serious proarrhythmic effects and death, use only when response to other treatment is unacceptable (due to lack of efficacy or intolerable adverse effects).
  • Prior to administration, obtain 12-lead ECG to exclude the presence of prolonged QT interval (QTc interval >440 msec in males, >450 msec in females).
  • Do notadminister droperidol if QT interval is prolonged.
  • If potential benefit outweighs risk of serious arrhythmia, monitor for arrhythmia with ECG prior to administration and for 2–3 hours after completion of therapy.
  • Contraindicated in patients with known or suspected QT prolongation, including congenital long QT syndrome.
  • Use with extreme caution in patients at risk for prolonged QT syndrome (e.g., CHF, bradycardia, diuretic use, cardiac hypertrophy, hypokalemia, hypomagnesemia, use of other drugs known to prolong QT interval). Other risk factors may include age >65 years, alcohol abuse, and concomitant use of benzodiazepines, volatile anesthetics, or IV opiates. (See Prolonged QT Syndrome under Cautions.)
  • Initiate droperidol at low dose and increase with caution as needed to achieve desired effect.

What is this medicine?

DROPERIDOL (droe PER i dole) is used to prevent nausea and vomiting associated with surgery or other procedures.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • heart disease, including heart failure
  • if you frequently drink alcohol-containing beverages
  • irregular heart beats or slow heart rate
  • kidney disease
  • liver disease
  • an unusual or allergic reaction to droperidol, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a muscle or for slow injection into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. While this medicine may be prescribed for children as young as 2 years for selected conditions, precautions do apply.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • abarelix
  • alfuzosin
  • amoxapine
  • apomorphine
  • arsenic trioxide
  • certain antibiotics like ciprofloxacin, clarithromycin, erythromycin, gatifloxacin, gemifloxacin, levofloxacin, moxifloxacin, norfloxacin, ofloxacin, sparfloxacin, telithromycin, and troleandomycin
  • certain medicines used in chemotherapy like daunorubicin, doxorubicin
  • chloroquine
  • cisapride
  • clozapine
  • cyclobenzaprine
  • general and local anesthetics
  • halofantrine
  • haloperidol
  • levomethadyl
  • maprotiline
  • medicines to control heart rhythm
  • methadone
  • octreotide
  • other medicines for nausea and vomiting like dolasetron and palonosetron
  • pentamidine
  • phenothiazines like chlorpromazine, fluphenazine, mesoridazine, perphenazine, prochlorperazine, thioridazine, and trifluoperazine
  • pimozide
  • ranolazine
  • risperidone
  • sertindole
  • sodium phosphate salts
  • tacrolimus
  • tricyclic antidepressants like amitriptyline, desipramine, nortriptyline, and others
  • vardenafil
  • ziprasidone

This medicine may also interact with the following medications:

  • barbiturate medicines for inducing sleep or treating seizures
  • diuretics
  • laxatives
  • medicines for depression
  • prescription pain medicines

What should I watch for while using this medicine?

Your condition will be closely monitored following administration of this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • fainting spells or dizziness
  • fast or irregular heartbeat (palpitations)
  • hallucinations
  • movement difficulties
  • muscle spasms or stiffness
  • restlessness or agitation, nervousness
  • rolling or rotating movement of the eyes
  • slow or difficult breathing
  • sweating

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • chills
  • facial flushing
  • involuntary muscle movements
  • trembling

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: April 09, 2009
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