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Dinoprostone Vaginal suppository

Sometimes it is used after a miscarriage

Generic Name: dinoprostone  |  Brand Name: Prepidil

Brand Names: Prostin E2, Prepidil, Cervidil

What is this medicine?

DINOPROSTONE, PROSTAGLANDIN E2 (dye noe PROST one pros tuh GLAN din) stimulates contractions to empty the uterus. Sometimes it is used after a miscarriage. It can be used when necessary to induce abortion between the 12th and 20th week of pregnancy. This medicine may also be used to treat a condition called benign hydatidiform mole.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of the following conditions:
  • heart disease
  • kidney disease
  • liver disease
  • lung or breathing disease, like asthma
  • vaginal inflammation or infection
  • an unusual or allergic reaction to dinoprostone, prostaglandins, other medicines, foods, dyes, or preservatives
  • breast-feeding

How should I use this medicine?

This medicine is inserted into the vagina by a health-care professional in a hospital or clinic setting. Remain lying down for 10 minutes after it is inserted.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

  • oxytocin

What should I watch for while using this medicine?

You will be closely monitored while you receive this medicine.

This medicine can affect other muscles outside of the uterus and cause side effects. Most of these effects will go away quickly.

Contact your doctor or health care professional immediately if you get an unpleasant vaginal discharge, continued fever, chills and shivering, or increase in vaginal bleeding several days after treatment.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • chest pain or palpitations
  • continuous or excessive vaginal bleeding
  • dizziness or fainting
  • fever
  • foul smelling vaginal discharge
  • abdominal pain, or severe cramping pains

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • chills or shivering
  • hot flashes
  • headache
  • nausea, vomiting

Where should I keep my medicine?

This does not apply. You will not be given this medicine to store at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: April 09, 2009
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