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Dihydroergotamine Mesylate Solution for injection

It is used to treat migraine headaches with or without aura

Generic Name: dihydroergotamine  |  Brand Name: D.H.E. 45

Brand Names: Dihydroergotamine Mesylate, D.H.E. 45

There is an FDA Alert for this drug. Click here to view it.

  • Possible serious and/or life-threatening cerebral and/or peripheral ischemia when administered concomitantly with potent CYP3A4 inhibitors (see Interactions); concomitant use contraindicated.

What is this medicine?

DIHYDROERGOTAMINE (dye hye droe er GOT a meen) is used to treat migraine headaches with or without aura. It should not be used to prevent migraine headaches.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood vessel problems, or surgery on your arteries
  • chest pain
  • heart disease
  • high blood pressure
  • infection
  • kidney disease
  • liver disease
  • risk factors for heart disease like smoking, high cholesterol, a family history of heart disease, or if you are a postmenopausal female or a male over 40 years of age
  • an unusual or allergic reaction to dihydroergotamine, ergot alkaloids, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection under the skin, into a muscle, or into a vein. You will be taught how to prepare and give this medicine. Use exactly as directed. Do not take your medicine more often than directed. Do not use more than the maximum daily or weekly dose. This drug is not for daily use.

It is important that you put your used needles and syringes in a special sharps container. Do not put them in a trash can. If you do not have a sharps container, call your pharmacist or healthcare provider to get one.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply. Use this medicine only when you have a headache. Do not use double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medicines:
  • clarithromycin
  • cocaine
  • conivaptan
  • dexfenfluramine
  • ergot alkaloids like dihydroergotamine, ergonovine, ergotamine, methylergonovine
  • ephedrine
  • erythromycin
  • feverfew
  • grapefruit juice
  • imatinib
  • medicines for migraine headache like almotriptan, eletriptan, frovatriptan, naratriptan, rizatriptan, sumatriptan, zolmitriptan
  • medicines used to treat colds or breathing difficulties
  • medicines used to treat fungal infections like itraconazole, ketoconazole, posaconazole and voriconazole
  • midodrine
  • nefazodone
  • nitrate medicines like nitroglycerin
  • some medicines for HIV
  • troleandomycin

This medicine may also interact with the following medications:

  • medicines for blood pressure
  • medicines for mental depression
  • nicotine

What should I watch for while using this medicine?

Visit your doctor for regular check ups. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To reduce dizzy or fainting spells, do not sit or stand up quickly, especially if you are an older patient. Alcohol can increase drowsiness, dizziness and flushing. Avoid alcoholic drinks.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • fast, irregular heartbeat
  • muscle pain or cramps
  • pain, tightness, or discomfort in your chest
  • pain, tingling, numbness in the hands or feet
  • weakness in legs
  • vomiting

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • changes in the taste of food
  • cold hands or feet
  • nasal congestion or sore throat
  • nausea


Last Updated: November 30, 2009
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