Drugs A - Z

Didanosine Oral capsule

It is used with other medicines to treat HIV

Generic Name: didanosine  |  Brand Name: Videx

Brand Names: Videx, Videx EC

There is an FDA Alert for this drug. Click here to view it.

  • Fatal and nonfatal pancreatitis reported. Temporarily interrupt didanosine therapy in patients with suspected pancreatitis; discontinue in patients with confirmed pancreatitis. (See Pancreatitis under Cautions.)
  • Lactic acidosis and severe hepatomegaly with steatosis (including some fatalities) reported rarely in patients receiving nucleoside reverse transcriptase inhibitors (NRTIs) alone or in conjunction with other antiretrovirals. (See Lactic Acidosis and Severe Hepatomegaly with Steatosis under Cautions.)
  • Fatal lactic acidosis reported in pregnant women receiving didanosine and stavudine with other antiretrovirals. Didanosine in conjunction with stavudine should be used with caution in pregnant women and only if potential benefits outweigh potential risks. (See Pregnancy under Cautions.)

REMS:

FDA approved a REMS for didanosine to ensure that the benefits of a drug outweigh the risks. However, FDA later rescinded REMS requirements. See the FDA REMS page ([Web]) or the ASHP REMS Resource Center ([Web]).

What is this medicine?

DIDANOSINE, ddI (dye DAN oh seen) is an antiretroviral medicine. It is used with other medicines to treat HIV. This medicine is not a cure for HIV. It will not stop the spread of HIV to others.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • gout
  • if you frequently drink alcohol containing drinks
  • kidney disease
  • liver disease
  • pancreatitis
  • tingling or numbness in the hands or feet
  • an unusual or allergic reaction to didanosine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine on an empty stomach, at least 30 minutes before or 2 hours after food. Do not take with food. Do not chew or crush. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your anti-HIV therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the HIV virus resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with the following medications:
  • allopurinol
  • ribavirin
  • zalcitabine, ddC

This medicine may also interact with the following medications:

  • delavirdine
  • ganciclovir
  • hydroxyurea
  • indinavir
  • itraconazole
  • ketoconazole
  • methadone
  • some antibiotics like ciprofloxacin, levofloxacin, tetracycline
  • stavudine, d4T
  • tenofovir

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular check ups. Discuss any new symptoms with your doctor. You will need to have important blood work done while on this medicine.

HIV is spread to others through sexual or blood contact. Talk to your doctor about how to stop the spread of HIV.

Do not treat severe stomach pain, nausea or vomiting with over-the-counter medicines. Contact your doctor.

Alcohol can increase the risk of developing severe side effects when taken with this medicine. Avoid alcoholic drinks.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • changes in vision
  • nausea, vomiting, unusual stomach upset or pain
  • tingling, pain or numbness in the hands or feet
  • unusual bleeding or bruising
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • dry mouth or eyes
  • headache
  • heartburn or gas
  • loss of appetite
  • muscle pain
  • skin rash
  • weight gain around waist, back, or thinning of face, arms, legs

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: June 22, 2009
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