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Denileukin Diftitox (E. coli) Solution for injection

It slows the growth of cancer cells

Generic Name: denileukin diftitox  |  Brand Name: Ontak

Brand Names: Ontak

There is an FDA Alert for this drug. Click here to view it.

What is this medicine?

DENILEUKIN DEFTITOX (DEN i loo kin DEF ti toks) is a chemotherapy drug. It slows the growth of cancer cells. This medicine is used to treat cutaneous T-cell lymphoma.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood vessel disease
  • fever or infection
  • heart disease
  • an unusual or allergic reaction to denileukin deftitox, diphtheria toxin, interleukin-2, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This drug is given as an infusion into a vein. It is administered in a hospital or clinic by a specially trained health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?

Interactions are not expected.

What should I watch for while using this medicine?

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may cause diarrhea. It may last a long time. Call your doctor or health care professional if you have diarrhea for more than 3 days or are unable to take food or fluids.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.


Last Updated: April 07, 2009
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