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Dantrolene Sodium Solution for injection

It is used to prevent and to treat a condition called malignant hyperthermia

Generic Name: dantrolene

Brand Names: Revonto, Dantrium, Dantrolene Sodium, Ryanodex

There is an FDA Alert for this drug. Click here to view it.

    Hepatic Effects of Oral Dantrolene
  • Risk of developing potentially fatal, hepatic injury (e.g., hepatitis); should not be used for unlabeled indications.
  • Females, patients >35 years of age, and those receiving other drugs (especially estrogens) concomitantly are at greatest risk.
  • Risk of symptomatic hepatitis (fatal and nonfatal) may be dose dependent; incidence much higher at dosages ≥800 mg daily than at dosages ≤400 mg daily. Even intermittent, short courses at higher dosages associated with increased risk. Use lowest possible effective dose.
  • Overt hepatitis most frequently observed between 3rd and 12th month of therapy.
  • Frequently monitor hepatic function. (See Hepatic Effects under Cautions.)
  • If benefits are not evident within 45 days, discontinue therapy.

What is this medicine?

DANTROLENE (DAN troe leen) is a muscle relaxant. It is used to prevent and to treat a condition called malignant hyperthermia.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • heart disease
  • liver disease
  • lung or breathing disease, like asthma
  • an unusual or allergic reaction to dantrolene, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for injection into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

  • alcohol
  • female hormones, like estrogens or progestins and birth control pills
  • medicines for anxiety or sleep like diazepam, temazepam
  • medicines for heart disease like verapamil
  • medicines for pain

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

You may get drowsy or dizzy. Muscle weakness may occur. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. Be careful walking down stairs. Use caution to reduce the risk of dizzy or fainting spells or falls. Alcohol can make you more drowsy. Avoid alcoholic drinks.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • chest pain
  • confusion, depression, nervousness
  • fever
  • swelling of feet or legs

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • drowsy, dizzy
  • loss of appetite
  • muscle weakness for up to 48 hours after treatment
  • slurred speech
  • trouble sleeping
  • unusually weak or tired

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: April 09, 2009
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