Drugs A - Z

Collagenase Solution for injection

It is used to treat Dupuytren's contracture

Generic Name: Xiaflex

What is this medicine?

COLLAGENASE (kohl LAH jen ace) is used to treat Dupuytren's contracture. This medicine may help straighten a bent finger by breaking up hard tissue.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

-hemophilia
-low platelet counts
-take medicines that treat or prevent blood clots
-an unusual or allergic reaction to collagenase, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

How should I use this medicine?

This medicine is for injection into the hand. It is given by a health care professional in a hospital or clinic setting.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?


-aspirin and aspirin-like medicines
-certain medicines that treat or prevent blood clots like warfarin, enoxaparin, and dalteparin

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

Return to your doctor the day after your hand is injected. In the meantime, do not flex or extend the fingers of your hand that was injected. Do not touch your finger that was injected, and elevate your hand until bedtime. Do not perform activity with the injected hand until you are told that it is OK. Follow any instructions about wearing a splint or performing finger exercises.

Immediately call your doctor if you get a fever or chills. Also, call them if you get increasing redness or swelling in the hand, if you have numbness or tingling in the treated finger, or if you have trouble bending the finger after the swelling goes down.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):

-irritation at site where injected
-pain at site where injected
-swelling of the injected hand
-unusual bleeding or bruising

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: April 19, 2013
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