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Clomipramine Hydrochloride Oral capsule

It is used to treat obsessive-compulsive disorder

Generic Name: clomiPRAMINE  |  Brand Name: Anafranil

Brand Names: Anafranil

There is an FDA Alert for this drug. Click here to view it.

What is this medicine?

CLOMIPRAMINE (kloe MI pra meen) is an antidepressant. It is used to treat obsessive-compulsive disorder.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • an alcohol problem
  • asthma, difficulty breathing
  • bipolar disease or schizophrenia
  • difficulty passing urine, prostate trouble
  • glaucoma
  • heart disease or previous heart attack
  • liver disease
  • over active thyroid
  • seizures
  • thoughts or plans of suicide, previous suicide attempt, or family history of suicide attempt
  • an unusual or allergic reaction to clomipramine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food to avoid stomach upset. Take your doses at regular intervals. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 10 years for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications
  • amoxapine
  • arsenic trioxide
  • certain heart medicines
  • cisapride
  • halofantrine
  • levomethadyl
  • linezolid
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • methylene blue (injected into a vein)
  • other medicines for mental depression
  • phenothiazines like perphenazine, thioridazine and chlorpromazine
  • pimozide
  • probucol
  • procarbazine
  • sparfloxacin
  • St. John's Wort
  • ziprasidone

This medicine may also interact with the following medications:

  • atropine and related drugs like hyoscyamine, scopolamine, tolterodine and others
  • barbiturate medicines for inducing sleep or treating seizures like phenobarbital
  • cimetidine
  • clonidine
  • digoxin
  • medicines for anxiety or sleeping problems
  • medicines for colds, flu and breathing difficulties, like pseudoephedrine
  • medicines for hay fever or allergies
  • seizure or epilepsy medicine like phenytoin
  • stimulants like dexmethylphenidate or methylphenidate
  • thyroid hormones
  • warfarin


Last Updated: May 06, 2013
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