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Clindamycin Palmitate Hydrochloride Oral solution

It is used to treat certain kinds of bacterial infections

Generic Name: clindamycin

Brand Names: Cleocin HCl, Clindamycin Phosphate, Cleocin Pediatric, Clindamycin Hydrochloride

There is an FDA Alert for this drug. Click here to view it.

    Diarrhea and Colitis
  • Clostridium difficile-associated diarrhea and colitis (CDAD; also known as antibiotic-associated diarrhea and colitis or pseudomembranous colitis) has been reported with nearly all anti-infectives, including clindamycin, and may range in severity from mild to life-threatening. Anti-infectives alter normal flora of the colon and may permit overgrowth of clostridia; a toxin produced by C. difficile is one primary cause of antibiotic-associated colitis.
  • It is important to consider a diagnosis of CDAD in patients who develop diarrhea subsequent to clindamycin treatment. Diarrhea, colitis, and pseudomembranous colitis have been observed to begin up to several weeks after cessation of clindamycin therapy.
  • After a diagnosis of CDAD has been established, initiate therapeutic measures.

    Mild cases usually respond to drug discontinuation alone.

    In moderate to severe cases, consideration should be given to management with fluids and electrolytes, protein supplementation, and treatment with an anti-infective clinically effective against CDAD. (See Superinfection/Clostridium difficile-associated Diarrhea and Colitis under Cautions.)

  • Because clindamycin has been associated with severe colitis (potentially fatal), it should be reserved for treatment of serious infections when less toxic anti-infectives are inappropriate.
  • Do not use for nonbacterial infections.

What is this medicine?

CLINDAMYCIN (KLIN da MYE sin) is a lincosamide antibiotic. It is used to treat certain kinds of bacterial infections. It will not work for colds, flu, or other viral infections.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • kidney disease
  • liver disease
  • stomach problems like colitis
  • an unusual or allergic reaction to clindamycin, lincomycin, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on your prescription label. Shake well before using. Use a specially marked spoon or container to measure your medicine. Ask your pharmacist if you do not have one. Household spoons are not accurate. You can take this medicine with food or on an empty stomach. If the medicine upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Take all of your medicine as directed even if you think your are better. Do not skip doses or stop your medicine early.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • chloramphenicol
  • erythromycin
  • kaolin products

What should I watch for while using this medicine?

Tell your doctor or health care professional if your symptoms do not improve or if they get worse.

Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • dark urine
  • redness, blistering, peeling or loosening of the skin, including inside the mouth
  • trouble urinating
  • unusual bleeding or bruising
  • unusually weak or tired
  • yellowing of eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • itching in the rectal or genital area
  • joint pain
  • nausea, vomiting
  • stomach pain

Where should I keep my medicine?

Keep out of the reach of children.

After this medicine is mixed by your pharmacist, store at room temperature between 20 and 25 degrees C (68 and 77 degrees F). Do not refrigerate. Throw away any unused medicine after 14 days.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: March 23, 2009
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