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Cisplatin Solution for injection

It targets fast dividing cells, like cancer cells, and causes these cells to die

Generic Name: cisplatin

Brand Names: Cisplatin Novaplus, Platinol (Restricted Access), Platinol-Aq, Platinol

There is an FDA Alert for this drug. Click here to view it.

    Experience of Supervising Clinician
  • Use under supervision of a qualified clinician experienced in therapy with antineoplastic agents. Use only when adequate treatment facilities for appropriate management of therapy and complications are available.
    Dose-Related Toxicities
  • Risk of dose-related toxicities, including myelosuppression, nausea, vomiting, and cumulative, severe renal toxicity. Dosages >100 mg/m2/cycle once every 3–4 weeks rarely used.
  • Risk of ototoxicity; more pronounced in children. Manifestations include tinnitus, loss of high frequency hearing, decreased hearing acuity, and, occasionally, deafness.
  • Risk of anaphylactoid reactions (e.g., facial edema, bronchoconstriction, wheezing, tachycardia, hypotension); may occur within minutes following administration. (See Anaphylactoid Reactions under Cautions.) IV epinephrine, corticosteroids, and antihistamines have been effectively employed to alleviate symptoms.
    Potential Medication Errors
  • Avoid accidental, potentially fatal, overdosage due to confusion with carboplatin (Paraplatin®) or due to failure to differentiate daily dosages from total dosage per cycle. Cisplatin dosages >100 mg/m2/cycle once every 3–4 weeks rarely used.

What is this medicine?

CISPLATIN (SIS pla tin) is a chemotherapy drug. It targets fast dividing cells, like cancer cells, and causes these cells to die. This medicine is used to treat many types of cancer like bladder, ovarian, and testicular cancers.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • blood disorders
  • hearing problems
  • kidney disease
  • recent or ongoing radiation therapy
  • an unusual or allergic reaction to cisplatin, carboplatin, other chemotherapy, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This drug is given as an infusion into a vein. It is administered in a hospital or clinic by a specially trained health care professional.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

It is important not to miss a dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?

  • dofetilide
  • foscarnet
  • medicines for seizures
  • medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim
  • probenecid
  • pyridoxine used with altretamine
  • rituximab
  • some antibiotics like amikacin, gentamicin, neomycin, polymyxin B, streptomycin, tobramycin
  • sulfinpyrazone
  • vaccines
  • zalcitabine

Talk to your doctor or health care professional before taking any of these medicines:

  • acetaminophen
  • aspirin
  • ibuprofen
  • ketoprofen
  • naproxen

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine. You will need important blood work done while you are taking this medicine.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Drink fluids as directed while you are taking this medicine. This will help protect your kidneys.

Call your doctor or health care professional if you get diarrhea. Do not treat yourself.

Last Updated: March 24, 2009
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