Use under supervision of a qualified clinician experienced in therapy with antineoplastic agents. Use only when adequate treatment facilities for appropriate management of therapy and complications are available.
Dose-Related Toxicities
Risk of dose-related toxicities, including myelosuppression, nausea, vomiting, and cumulative, severe renal toxicity. Dosages >100 mg/m2/cycle once every 3–4 weeks rarely used.
Ototoxicity
Risk of ototoxicity; more pronounced in children. Manifestations include tinnitus, loss of high frequency hearing, decreased hearing acuity, and, occasionally, deafness.
Anaphylaxis
Risk of anaphylactoid reactions (e.g., facial edema, bronchoconstriction, wheezing, tachycardia, hypotension); may occur within minutes following administration. (See Anaphylactoid Reactions under Cautions.) IV epinephrine, corticosteroids, and antihistamines have been effectively employed to alleviate symptoms.
Potential Medication Errors
Avoid accidental, potentially fatal, overdosage due to confusion with carboplatin (Paraplatin®) or due to failure to differentiate daily dosages from total dosage per cycle. Cisplatin dosages >100 mg/m2/cycle once every 3–4 weeks rarely used.
CISPLATIN (SIS pla tin) is a chemotherapy drug. It targets fast dividing cells, like cancer cells, and causes these cells to die. This medicine is used to treat many types of cancer like bladder, ovarian, and testicular cancers.
This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
What should I tell my health care provider before I take this medicine?
They need to know if you have any of these conditions:
This drug is given as an infusion into a vein. It is administered in a hospital or clinic by a specially trained health care professional.
Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
Overdosage: If you think you have taken too much of this medicine contact a poison control center or emergency room at once.
NOTE: This medicine is only for you. Do not share this medicine with others.
What if I miss a dose?
It is important not to miss a dose. Call your doctor or health care professional if you are unable to keep an appointment.
This list may not describe all possible interactions. Give your health care provider a list of all the medicines, herbs, non-prescription drugs, or dietary supplements you use. Also tell them if you smoke, drink alcohol, or use illegal drugs. Some items may interact with your medicine.
What should I watch for while using this medicine?
Your condition will be monitored carefully while you are receiving this medicine. You will need important blood work done while you are taking this medicine.
This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.
In some cases, you may be given additional medicines to help with side effects. Follow all directions for their use.
Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.
This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.
Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.
Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.
Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.
Drink fluids as directed while you are taking this medicine. This will help protect your kidneys.
Call your doctor or health care professional if you get diarrhea. Do not treat yourself.
What side effects may I notice from receiving this medicine?
Side effects that you should report to your doctor or health care professional as soon as possible:
low blood counts - This drug may decrease the number of white blood cells, red blood cells and platelets. You may be at increased risk for infections and bleeding.
nausea and vomiting
pain, swelling, redness or irritation at the injection site
trouble passing urine or change in the amount of urine
Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):
changes in vision
loss of appetite
metallic taste in the mouth or changes in taste
This list may not describe all possible side effects. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Where should I keep my medicine?
This drug is given in a hospital or clinic and will not be stored at home.
NOTE:This sheet is a summary. It may not cover all possible information. If you have questions about this medicine, talk to your doctor, pharmacist, or health care provider.
Remember, keep this and all other medicines out of the reach of children,
never share your medicines with others, and use this medication only for the indication prescribed.
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