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Cidofovir Solution for injection

It is used to treat or prevent infections caused by certain kinds of viruses

Generic Name: cidofovir

Brand Names: Vistide

There is an FDA Alert for this drug. Click here to view it.

  • The major toxicity is renal impairment. Acute renal failure resulting in dialysis and/or contributing to death has occurred with as few as 1 or 2 doses of cidofovir.
  • To reduce risk of nephrotoxicity, IV prehydration with 0.9% sodium chloride prior to each cidofovir dose and concomitant probenecid must be used. (See Hydration and see Concomitant Probenecid under Dosage and Administration.) Renal function (serum creatinine and urine protein) must be monitored within 48 hours prior to each dose and dosage modified as appropriate based on any changes in renal function.
  • Cidofovir is contraindicated in patients receiving other nephrotoxic drugs.
  • Neutropenia has been observed in association with cidofovir; neutrophil counts should be closely monitored during treatment.
    Other Warnings
  • The only FDA-approved indication is treatment of cytomegalovirus (CMV) retinitis in HIV-infected patients.
  • In animal studies, cidofovir was carcinogenic, teratogenic, and caused hypospermia.

What is this medicine?

CIDOFOVIR (si DOF o veer) is an antiviral medicine. It is used to treat or prevent infections caused by certain kinds of viruses. It is commonly used to treat cytomegalovirus (CMV) infections of the eye.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • chronic diarrhea
  • dehydration
  • diabetes
  • kidney disease
  • low levels of white cells in the blood
  • previous treatment with foscarnet
  • an unusual or allergic reaction to cidofovir, probenecid, other medicines, foods, dyes, or preservatives
  • pregnancy or recent attempts to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

You will need to take another medicine, probenecid, with this medicine. Take all of your medicine as directed. Do not skip doses or stop your medicine early.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

It is important not to miss your dose. Call your doctor or health care professional if you are unable to keep an appointment.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • medicines for infection like acyclovir, adefovir, amphoterin B, bacitracin, cidofovir, foscarnet, ganciclovir, gentamicin, pentamidine, vancomycin
  • NSAIDS, medicines for pain and inflammation, like ibuprofen or naproxen
  • tacrolimus

This medicine may also interact with the following medications:

  • aspirin and aspirin-like medicines
  • cisplatin
  • cyclosporine
  • pamidronate
  • zidovudine
  • zoledronic acid

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need regular blood checks. Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse.

This medicine is used to treat cytomegalovirus (CMV) infections of the eye(s). This medicine is not a cure for CMV. Life long therapy may be needed.

Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Women: use effective birth control methods during treatment with this medicine and for 1 month after stopping therapy. Men: use barrier contraceptive methods during treatment with this medicine and for 3 months after stopping therapy.

This medicine has caused breast cancer in animal studies. Talk to your doctor about the risks and benefits of taking this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • changes in hearing, 'ringing' in the ears
  • changes in vision
  • fast, irregular heartbeat
  • fever or chills, sore throat
  • general ill feeling or flu-like symptoms
  • swelling of the ankles, hands, feet
  • trouble passing urine or change in the amount of urine
  • unusually weak or tired
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • aches, pains
  • dry skin
  • loss of hair
  • nausea, vomiting

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.

Last Updated: March 23, 2009
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