Drugs A - Z

Clonidine Hydrochloride, Chlorthalidone Oral tablet

Chlorthalidone is a diuretic

Generic Name: Clonidine Hydrochloride

There is an FDA Alert for this drug. Click here to view it.

    Dilution Warning
  • Concentrate for epidural injection must be diluted prior to administration.
    Obstetric, Postpartum, and Perioperative Pain
  • Not recommended for obstetric, postpartum, or perioperative pain management.
  • Risk of hemodynamic instability, especially hypotension and bradycardia, from epidural use may be unacceptable in these patients.
  • Rarely, potential benefits may outweigh possible risks in obstetric, postpartum, or perioperative patients.

What is this medicine?

CHLORTHALIDONE; CLONIDINE (klor THAL i done ; KLOE ni deen) is a combination of two medicines that are used to treat high blood pressure. Chlorthalidone is a diuretic. It lowers blood pressure and increases the amount of urine passed, which causes the body to lose salt and water. Clonidine also lowers blood pressure.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

-asthma
-diabetes
-gout
-kidney disease
-liver disease
-systemic lupus erythematosus (SLE)
-an unusual or allergic reaction to chlorthalidone, sulfa drugs, clonidine, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant
-breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. You can take it with or without food. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Remember that you will need to pass urine frequently after taking this medicine. Do not suddenly stop taking this medicine. You must gradually reduce the dose or you may get a dangerous increase in blood pressure. Ask your doctor or health care professional for advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?


-barbiturate medicines for inducing sleep or treating seizures like phenobarbital
-certain medicines for depression, like amitriptyline or imipramine
-digoxin
-ephedra, Ma Huang
-glycyrrhizin (licorice)
-lithium
-medicines for diabetes
-other medicines for high blood pressure
-steroid medicines like prednisone or cortisone

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure regularly as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her. You may need blood work done while you are taking this medicine.

You may need to be on a special diet while taking this medicine. Ask your doctor.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. To avoid dizzy or fainting spells, do not stand or sit up quickly, especially if you are an older person. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

This medicine may affect blood sugar levels. If you have diabetes, check with your doctor or health care professional before you change your diet or the dose of your diabetic medicine.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.

If you are going to have surgery tell your doctor or health care professional that you are taking this medicine.


Last Updated: October 20, 2010
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