Drugs A - Z

Chlorpheniramine Maleate, Guaifenesin, Hydrocodone Bitartrate, Pseudoephedrine Hydrochloride Oral solution

It is used to treat the cough and congestion of colds and other respiratory infections

Generic Name: chlorpheniramine/guaifenesin/hydrocodone/PSE

Brand Names: Z-Tuss 2

What is this medicine?

CHLORPHENIRAMINE; GUAIFENESIN; HYDROCODONE; PSEUDOEPHEDRINE (klor fen IR a meen; gwye FEN e sin; hye droe KOE done; soo doe e FED rin) is a combination of an antihistamine, an expectorant, a cough suppressant, and a decongestant. It is used to treat the cough and congestion of colds and other respiratory infections. This medicine will not treat an infection.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • drug abuse or addiction
  • glaucoma
  • heart disease
  • high blood pressure
  • if you have taken an MAOI like Carbex, Eldepryl, Marplan, Nardil, or Parnate in last 14 days
  • kidney disease
  • liver disease
  • lung or breathing disease, like asthma
  • recent head injury
  • stomach problems
  • trouble passing urine
  • an unusual or allergic reaction to chlorpheniramine, codeine, guaifenesin, hydrocodone, pseudoephedrine, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Use a specially marked spoon or container to measure each dose. Ask your pharmacist if you do not have one. Household spoons are not accurate. You can take this medicine with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 6 years old for selected conditions, precautions do apply. This medicine is not approved for use in children less than 6 years old.

Patients over 65 years old may have a stronger reaction and need a smaller dose.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • alcohol
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • stimulant medicines for attention disorders, weight loss, or to stay awake

This medicine may also interact with the following medications:

  • atropine
  • antihistamines for allergy, cough, and cold
  • barbiturates like phenobarbital
  • certain medicines for bladder problems like oxybutynin, tolterodine
  • certain medicines for Parkinson's disease like benztropine, trihexyphenidyl
  • certain medicines for stomach problems like dicyclomine, hyoscyamine
  • certain medicines for travel sickness like scopolamine
  • ipratropium
  • medicines for blood pressure
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for sleep
  • muscle relaxants
  • naltrexone
  • narcotic medicines (opiates) for pain
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
  • tramadol


Last Updated: August 28, 2012
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Chlorpheniramine/guaifenesin/hydrocodone/PSE

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