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Bupropion Hydrochloride Oral tablet, extended release 24 hour [Depression/Mood Disorders]

It is used to treat depression.

Generic Name: buPROPion  |  Brand Name: Wellbutrin

Brand Names: Wellbutrin XL, Budeprion XL, Budeprion SR, Wellbutrin SR, BuPROPion Hydrochloride SR, Zyban, Zyban Advantage Pack, Wellbutrin, BuPROPion Hydrochloride XL

There is an FDA Alert for this drug. Click here to view it.

What is this medicine?

BUPROPION (byoo PROE pee on) is used to treat depression.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • an eating disorder, such as anorexia or bulimia
  • bipolar disorder or psychosis
  • diabetes or high blood sugar, treated with medication
  • head injury or brain tumor
  • heart disease, previous heart attack, or irregular heart beat
  • high blood pressure
  • kidney or liver disease
  • seizures (convulsions)
  • suicidal thoughts or a previous suicide attempt
  • Tourette's syndrome
  • weight loss
  • an unusual or allergic reaction to bupropion, other medicines, foods, dyes, or preservatives
  • breast-feeding
  • pregnant or trying to become pregnant

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Do not crush, chew, or cut these tablets. This medicine is taken once daily at the same time each day. Do not take your medicine more often than directed. Do not stop taking this medicine suddenly except upon the advice of your doctor. Stopping this medicine too quickly may cause serious side effects or your condition may worsen.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, skip the missed dose and take your next tablet at the regular time. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • linezolid
  • MAOIs like Azilect, Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • methylene blue (injected into a vein)
  • other medicines that contain bupropion like Zyban

This medicine may also interact with the following medications:

  • alcohol
  • certain medicines for anxiety or sleep
  • certain medicines for blood pressure like metoprolol, propranolol
  • certain medicines for depression or psychotic disturbances
  • certain medicines for HIV or AIDS like efavirenz, lopinavir, nelfinavir, ritonavir
  • certain medicines for irregular heart beat like propafenone, flecainide
  • certain medicines for Parkinson's disease like amantadine, levodopa
  • certain medicines for seizures like carbamazepine, phenytoin, phenobarbital
  • cimetidine
  • clopidogrel
  • cyclophosphamide
  • furazolidone
  • isoniazid
  • nicotine
  • orphenadrine
  • procarbazine
  • steroid medicines like prednisone or cortisone
  • stimulant medicines for attention disorders, weight loss, or to stay awake
  • tamoxifen
  • theophylline
  • thiotepa
  • ticlopidine
  • tramadol
  • warfarin


Last Updated: May 06, 2013
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