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Buprenorphine Hydrochloride, Naloxone Hydrochloride Sublingual tablet

It is used to treat certain types of drug dependence.

Generic Name: Subutex

There is an FDA Alert for this drug. Click here to view it.

What is this medicine?

BUPRENORPHINE; NALOXONE (byoo pre NOR feen; nal OX one) is used to treat certain types of drug dependence.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • brain tumor
  • drink more than 3 alcohol-containing drinks per day
  • head injury
  • heart disease
  • kidney disease
  • liver disease
  • lung disease such as asthma or COPD
  • an unusual or allergic reaction to buprenorphine, naloxone, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Place this medicine under the tongue and let it dissolve. Several minutes will be needed to let it fully dissolve. Follow the directions on the prescription label. Leave this medicine in the sealed foil pack until you are ready to use it. If your dose requires you to take more than 2 tablets at once, either place all the tablets at once under the tongue, or if you cannot fit more than 2 tablets comfortably, place 2 tablets at a time under the tongue. Either way, you should hold the tablets under the tongue until they completely dissolve. Do not swallow or chew this medicine. Take your medicine at regular intervals. Do not take your medicine more often than directed.

A special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 16 years of age for selected conditions, precautions do apply.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • butorphanol
  • nalbuphine
  • pentazocine

This medicine may also interact with the following medications:

  • alcohol
  • antibiotics like erythromycin and clarithromycin
  • antihistamines for allergy, cough and cold
  • barbiturates like phenobarbital
  • carbamazepine
  • general anesthetics
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for fungal infections like fluconazole, itraconazole, ketoconazole, and voriconazole
  • medicines for sleep
  • medicines used to treat HIV infection or AIDS like ritonavir, saquinavir, and indinavir
  • muscle relaxants
  • narcotic medicines (opiates) for pain
  • phenothiazines like chlorpromazine, mesoridazine, prochlorperazine, thioridazine
  • phenytoin
  • rifampin or rifampicin
  • tramadol


Last Updated: August 29, 2012
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