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Bisoprolol Fumarate, Hydrochlorothiazide Oral tablet

It is used to treat high blood pressure

Generic Name: bisoprolol  |  Brand Name: Zebeta

Brand Names: Bisoprolol Fumarate, Zebeta

What is this medicine?

BISOPROLOL; HYDROCHLOROTHIAZIDE (bis OH proe lol; hye droe klor oh THYE a zide) is a combination of a beta-blocker and a diuretic. It is used to treat high blood pressure.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • circulation problems, or blood vessel disease
  • decreased urine
  • diabetes
  • heart disease, heart failure or a history of heart attack
  • kidney disease
  • liver disease
  • lung or breathing disease, like asthma
  • slow heart rate
  • thyroid disease
  • an unusual or allergic reaction to hydrochlorothiazide, bisoprolol, sulfa drugs, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • barbiturates, like phenobarbital
  • cholestyramine
  • colestipol
  • corticosteroids, like prednisone
  • lithium
  • medicines for chest pain or angina
  • medicines for diabetes
  • medicines for high blood pressure or heart failure
  • medicines to control heart rhythm
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • prescription pain medicines
  • rifampin
  • skeletal muscle relaxants like tubocurarine

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. Check your blood pressure as directed. Ask your doctor or health care professional what your blood pressure should be and when you should contact him or her.

Check with your doctor or health care professional if you get an attack of severe diarrhea, nausea and vomiting, or if you sweat a lot. The loss of too much body fluid can make it dangerous for you to take this medicine.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this drug affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol can make you more drowsy and dizzy. Avoid alcoholic drinks.

This medicine may affect your blood sugar level. If you have diabetes, check with your doctor or health care professional before changing the dose of your diabetic medicine.

This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.

Do not treat yourself for coughs, colds, or pain while you are taking this medicine without asking your doctor or health care professional for advice. Some ingredients may increase your blood pressure.


Last Updated: September 07, 2011
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