Drugs A - Z

Diphenoxylate Hydrochloride, Atropine Sulfate Oral solution

It is used to treat diarrhea.

Generic Name: atropine-diphenoxylate

Brand Names: Atropine SO4-Diphenoxylate HCl, Vi-Atro, Lonox, Lomocot, Lomotil

What is this medicine?

ATROPINE; DIPHENOXYLATE (A troe peen dye fen OX i late) is used to treat diarrhea.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • bacterial food poisoning
  • colitis
  • dehydration
  • Down's syndrome
  • jaundice or liver disease
  • an unusual or allergic reaction to atropine, diphenoxylate, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth. Follow the directions on the prescription label. Use a specially marked spoon or dropper to measure your medicine. Ask your pharmacist if you do not have one. Household spoons are not accurate. For children, only use a specially marked dropper to measure the liquid. Take your medicine at regular intervals. Do not take it more often than directed. Once your diarrhea has been brought under control your doctor or health care professional may reduce your doses.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 years old for selected conditions, precautions do apply.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

  • alcohol
  • antihistamines for allergy, cough and cold
  • barbiturate medicines for inducing sleep or treating seizures
  • certain medicines for depression, anxiety, or psychotic disturbances
  • certain medicines for sleep
  • medicines for movement abnormalities as in Parkinson's disease, or for gastrointestinal problems
  • muscle relaxants
  • narcotic medicines (opiates) for pain

What should I watch for while using this medicine?

If your symptoms do not start to get better after taking this medicine for two days, check with your doctor or health care professional, you may have a problem that needs further evaluation. Check with your doctor or health care professional right away if you develop a fever or bloody diarrhea.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

Drinking plenty of water can also help prevent dehydration that can occur with diarrhea.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • bloated, swollen feeling
  • breathing problems
  • changes in vision
  • fast, irregular heartbeat
  • stomach pain

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • headache
  • loss of appetite
  • mood changes
  • nausea, vomiting
  • pain, tingling, numbness in the hands or feet


Last Updated: August 28, 2012
Licensed from
The Healthline Site, its content, such as text, graphics, images, search results, HealthMaps, Trust Marks, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.
Advertisement
Advertisement