Drugs A - Z

Atropine Sulfate, Difenoxin Hydrochloride Oral tablet

It is used to treat diarrhea.

Generic Name: Atropine Sulfate

There is an FDA Alert for this drug. Click here to view it.

    Pesticide and Chemical Warfare Agent Poisoning
  • Primary protection against exposure to chemical nerve agents and insecticide poisoning is the wearing of protective garments (e.g., specialized masks).
  • Do not rely solely on antidotes such as atropine and pralidoxime to provide complete protection from chemical nerve agents and insecticide poisoning.
  • Seek immediate medical attention after injection with an atropine auto-injector.

What is this medicine?

ATROPINE; DIFENOXIN (A troe peen dye fen NOX in) is used to treat diarrhea.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

-bacterial food poisoning
-Down's syndrome
-jaundice or liver disease
-an unusual or allergic reaction to atropine, difenoxin, other medicines, foods, dyes, or preservatives
-pregnant or trying to get pregnant

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed. Once your diarrhea has been brought under control your doctor or health care professional may reduce your doses.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. This medicine should not be used in children or infants under the age of 2 years.

Elderly patients may be more sensitive to the effects of this medicine.

Overdosage: If you think you've taken too much of this medicine contact a poison control center or emergency room at once.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

-antihistamines for allergy, cough and cold
-barbiturate medicines for inducing sleep or treating seizures
-certain medicines for depression, anxiety, or psychotic disturbances
-certain medicines for sleep
-MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
-muscle relaxants
-narcotic medicines (opiates) for pain

What should I watch for while using this medicine?

Tell your doctor or healthcare professional if your symptoms do not start to get better or if they get worse within two days of starting this medicine. Check with your doctor or health care professional right away if you develop a fever or bloody diarrhea.

You may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells. Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water may help. Contact your doctor if the problem does not go away or is severe.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:

-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
-bloated, swollen feeling
-breathing problems
-changes in vision
-facial flushing
-fast, irregular heartbeat
-stomach pain
Side effects that usually do not require medical attention (Report these to your doctor or health care professional if they continue or are bothersome.):

-dry mouth
-loss of appetite
-mood changes
-nausea, vomiting
-numbness or tingling in the hands and feet

Last Updated: August 28, 2012
Licensed from
The Healthline Site, its content, such as text, graphics, images, search results, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.