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Altretamine Oral capsule

This medicine is used to treat ovarian cancer

Generic Name: altretamine  |  Brand Name: Hexalen

Brand Names: Hexalen

There is an FDA Alert for this drug. Click here to view it.

    Experience of Supervising Clinician
  • Use only under the supervision of a clinician experienced in therapy with antineoplastic agents.

    Dose-Related Toxicities
  • Monitor peripheral blood counts at least monthly, prior to initiation of each course of therapy, and as clinically indicated.
  • Risk of neurotoxicity. Perform neurologic examinations regularly during therapy.

What is this medicine?

ALTRETAMINE (al TRET a meen) is a chemotherapy drug. This medicine is used to treat ovarian cancer.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • infection (especially virus infection such as chickenpox or herpes)
  • low blood counts like low platelets, red blood cells, white blood cells
  • neurologic problem like loss of feeling, pain or numbness
  • recent or ongoing radiation therapy
  • an unusual or allergic reaction to altretamine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. You can take this medicine with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What may interact with this medicine?

Do not take this medicine with any of the following medications:
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate

This medicine may also interact with the following medications:

  • cimetidine
  • medicines to increase blood counts like filgrastim, pegfilgrastim, sargramostim
  • pyridoxine (also known as vitamin B6)
  • vaccines

What should I watch for while using this medicine?

Visit your doctor for checks on your progress.

This drug may make you feel generally unwell. This is not uncommon, as chemotherapy can affect healthy cells as well as cancer cells. Report any side effects. Continue your course of treatment even though you feel ill unless your doctor tells you to stop.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug decreases your body's ability to fight infections. Try to avoid being around people who are sick.

This medicine may increase your risk to bruise or bleed. Call your doctor or health care professional if you notice any unusual bleeding.

Be careful brushing and flossing your teeth or using a toothpick because you may get an infection or bleed more easily. If you have any dental work done, tell your dentist you are receiving this medicine.

Avoid taking products that contain aspirin, acetaminophen, ibuprofen, naproxen, or ketoprofen unless instructed by your doctor. These medicines may hide a fever.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Men should inform their doctors if they wish to father a child. This medicine may lower sperm counts.


Last Updated: March 10, 2009
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