Drugs A - Z

Alprostadil Solution for injection [Ductus Arteriosus Patency]

It is used to treat neonates with a specific heart defect

Generic Name: alprostadil  |  Brand Name: Muse

Brand Names: Prostin VR Pediatric, Edex, Edex Refill, Caverject Impulse, Muse, Caverject, Alprostadil Novaplus

There is an FDA Alert for this drug. Click here to view it.

    Apnea
  • Apnea reported in 10–12% of neonates with congenital heart defects receiving IV or intra-arterial alprostadil; usually occurs during first hour of IV or intra-arterial infusion, particularly in neonates weighing <2 kg at birth.
  • Use in neonates only when adequate treatment facilities for assisted ventilation are readily available; monitor respiratory status throughout therapy.

What is this medicine?

ALPROSTADIL (al PROS ta dil) is a natural protein. It is used to treat neonates with a specific heart defect. This medicine is used for a short time until the condition can be corrected.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:
  • bleeding problems
  • breathing problems
  • stomach blockage
  • an unusual or allergic reaction to alprostadil or other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding

How should I use this medicine?

This medicine is for infusion into a vein. It is given by a health care professional in a hospital or clinic setting.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as newborn for selected conditions, precautions do apply.

What if I miss a dose?

This does not apply.

What may interact with this medicine?

  • medicines for blood pressure

What should I watch for while using this medicine?

Your condition will be monitored carefully while you are receiving this medicine.

What side effects may I notice from receiving this medicine?

Side effects that you should report to your doctor or health care professional as soon as possible:
  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • changes in blood pressure
  • changes in heart rate
  • extremely irritable
  • fever
  • flushing
  • seizures
  • trouble passing urine or change in the amount of urine
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • irritation at site where injected

Where should I keep my medicine?

This drug is given in a hospital or clinic and will not be stored at home.

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.


Last Updated: March 17, 2009
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