Pleural Effusion Health Article

Description

Pleural effusion is the accumulation of fluid in the pleural space. The pleural space is the region between the outer surface of each lung (visceral pleurae) and the membrane that surrounds each lung (parietal pleurae). Under normal conditions, the pleurae are kept wet with pleural fluid to allow movement of the lungs within the chest. The pleural fluid comes from cells that make up the pleurae. Pleural fluid is continuously being produced and removed, a process that is precisely controlled by many factors. Cancer can interfere with this delicate balance within the pleural space causing fluid to accumulate.

Cancer is responsible for 40% of all pleural effusions, which are then called malignant pleural effusions. Pleural effusion is the first symptom of cancer for up to 50% of the patients. Thirty-five percent of the cases of malignant pleural effusion are caused by lung cancer, 23% by breast cancer, and 10% by lymphoma.

Chest x rays and computed topography scans may be performed to diagnose pleural effusion. Thoracentesis, the removal of pleural fluid through a long needle, is usually performed for diagnostic purposes. Fluid removed by thoracentesis will be sent to the lab to be thoroughly evaluated. Thoracoscopy, in which a wand-like lighted camera (endoscope) is inserted through the chest, may be conducted to diagnose pleural effusion. During thoracoscopy, samples (biopsy) of pleura may be taken.

Pleural effusion can hinder the normal function of the lungs. Symptoms of pleural effusion include chest pain, chest heaviness, breathing difficulties, and a dry cough. Patients with malignant pleural effusions tend to be weak and have a short-span life expectancy. The prognosis depends on the type of cancer. Sixty-five percent of patients with malignant pleural effusions die within three months and 80% die within six months. However, patients with pleural effusion related to breast cancer have a longer life expectancy.

Causes

Malignant pleural effusions are most often associated with lymphomas, leukemia, breast cancer, gastrointestinal cancer, lung cancer, and ovarian cancer. For the majority of patients, pleural effusion occurs in the lung on the same side as the cancer. For one third of the patients, pleural effusion occurs in both lungs.

Pleural effusion in cancer patients can be caused by several different conditions. Blockage of the lymphatic system, a series of channels for drainage of body fluids, interferes with the removal of pleural fluid. Blockage of the veins of the lungs increases the pressure at the pleurae which causes fluid accumulation. Cancerous cells may seed onto pleurae and cause inflammation which increases fluid in the pleural space. High numbers of cancerous cells may collect in the pleural space (tumor cell suspensions) which causes extra fluid to be released. Accumulation of fluid in the abdominal cavity may cross over to the pleural space.

Treatments

Management of pleural effusion strives to relieve symptoms and improve quality of life. Cure is not always possible. The treatment method depends on the patient's age, prognosis, and location of the first tumor. Treatment for patients with pleural effusion who are asymptomatic (do not have symptoms) consists solely of observation.

Treatment options for pleural effusion include:

• Thoracentesis. Removal of the excess pleural fluid often relieves the symptoms of pleural effusion. However, effusion usually recurs within a few days. Repeat thoracentesis is not recommended, unless the patient has end-stage disease.
• Tube thoracostomy. A tube is inserted through the chest and into the pleural space to drain pleural fluid. When used alone, recurrence is very common.
• Indwelling pleural catheters. A thin flexible tube (catheter) is placed between the pleural cavity and the chest skin to allow drainage of pleural fluid. This method allows for continual drainage of pleural fluid without much pain.
• Pleurodesis. After tube thoracostomy, one of any number of chemicals (sclerosing agents) is put into the pleural space to cause the visceral and parietal pleurae to stick together. Chemical pleurodesis is considered to be the treatment of choice for patients with malignant pleural effusion.
• Pleurectomy. Surgical removal of the parietal pleura through an incision in the chest wall (thoracotomy) is nearly 100% effective. Pleurectomy is not routinely performed and is reserved for patients for whom other treatments have failed. To be eligible for pleurectomy, the patient must have a long life expectancy and be able to tolerate major surgery.
• Pleuroperitoneal shunt. This procedure places a rubber tube between the pleural space and the abdominal cavity. A pump is used to move excess fluid out of the pleural space and into the abdominal cavity, where it would be absorbed. The patient must press the pump for several minutes four times daily. Although not frequently used, this is an effective treatment for cases that failed tube thoracostomy and pleurodesis.
• External radiation. Patients who have pleural effusion caused by blockage of a lymph duct may be treated by radiation therapy. External radiation therapy is successful for patients with pleural effusion related to lymphoma.
• Supportive care. Patients with end-stage cancer may not receive treatment for pleural effusion. Pain medications and oxygen therapy can be provided to keep the patient comfortable.

Belinda Rowland, Ph.D.