Oxazolindinediones
Definition
Oxazolindinediones are anticonvulsants, indicated for the treatment of absence seizures (sometimes called petit mal seizures) associated with epilepsy and other seizure disorders.
Purpose
Oxazolindinediones are thought to decrease abnormal activity and excitement within the central nervous system (CNS) that may trigger seizures. While oxazolindinediones is often effective in controlling petit mal seizures associated with epilepsy, there is no known cure for the disorder. If
Description
In the United States, oxazolindinediones are sold under the generic name trimethadione and the brand name Tridione.
Recommended dosage
Oxazolindinediones are taken orally and are available in tablet, chewable tablet, or suspension forms. Oxazolindinediones are appropriate for pediatric and adult patients. Physicians prescribe the medication in varying total daily dosages. Typically, the total daily dosage is administered in three to four divided doses.
When beginning a course of treatment that includes oxazolindinediones, most physicians will prescribe a carefully scheduled dosing regimen. The physician will determine the proper initial dosage, and then gradually raise the patient's daily dosage over the course of several days or weeks until seizure control is achieved. Likewise, dosages are usually tapered down over time when ending treatment with oxazolindinediones.
It is important to not take a double dose of any anti-convulsant medication, including oxazolindinediones. If a daily dose is missed, it should be taken as soon as possible. However, if it is within four hours of the next scheduled dose, then the missed dose should be skipped.
Precautions
A physician should be consulted before taking oxazolindinediones with certain non-prescription medications. Patients should avoid alcohol and CNS depressants (medicines that can make one drowsy or less alert, such as antihistimines, sleep medications, and some pain medications) while taking oxazolindinediones or any other anticonvulsants, which can exacerbate the side effects of alcohol and other medications.
A course of treatment including oxazolindinediones may not be appropriate for persons with liver or kidney disease, anemia, eye disorders, mental illness, diabetes, high blood pressure, angina (chest pain), irregular heartbeats, or other heart problems. Periodic blood, urine, and liver function tests are advised for many patients (especially pediatric and elderly patients) using the medicine.
Persons taking oxazolindinediones should avoid prolonged exposure to sunlight and should wear protective clothing and sunscreen while outdoors. Oxazolindinediones may make skin sensitive to sunlight and prone to sunburn.
Before beginning treatment with oxazolindinediones, patients should notify their physician if they consume a large amount of alcohol, have a history of drug use, are pregnant, nursing, or plan on becoming pregnant. Anti-convulsant medications may increase the risk of some birth defects. Patients who become pregnant while taking oxazolindinediones should contact their physician.
