Multiple Myeloma Health Article

Associations

The cause of multiple myeloma has not been determined. However, a number of possible associations have been identified:

• decreased immune system function; the immune systems of older individuals may be less efficient at detecting and destroying cancer cells
• genetic (hereditary) factors, suggested by the increased incidence in some ethnic groups and among family members
• occupational factors, suggested by the increased incidence among agricultural, petroleum, wood, and leather workers, and cosmetologists

• long-term exposure to herbicides, pesticides, petroleum products, heavy metals, plastics, and dusts such as asbestos
• radiation exposure, as among Japanese atomic bomb survivors, nuclear weapons workers, and medical personnel such as radiologists
• Kaposi's sarcoma-associated herpes virus (also called human herpes virus-8 or HHV-8), found in the blood and bone marrow cells of many multiple myeloma patients

Early symptoms

The accumulation of malignant plasma cells can result in tiny cracks or fractures in bones. Malignant plasma cells in the bone marrow can suppress the formation of red and white blood cells and platelets. About 80% of individuals with multiple myeloma are anemic due to low red blood cell formation. Low white blood cell formation results in increased susceptibility to infection, since new, functional antibodies are not produced. In addition, normal circulating antibodies are rapidly destroyed. Low platelet formation can result in poor blood clotting. It is rare, however, that insufficient white blood cell and platelet formations are presenting signs of multiple myeloma.

These factors cause the early symptoms of multiple myeloma:

• pain in the lower back or ribs
• fatigue and paleness due to anemia (low red blood cell count)
• frequent and recurring infections, including bacterial pneumonia, urinary-tract and kidney infections, and shingles
• bleeding

Bone destruction

Bone pain, particularly in the backbone, hips, and skull, is often the first symptom of multiple myeloma. As malignant plasma cells increase in the bone marrow, replacing normal marrow, they exert pressure on the bone. As overly-active osteoclasts (large cells responsible for the breakdown of bone) remove bone tissue, the bone becomes soft. Fracture and spinal cord compression may occur.

Plasmacytomas (malignant tumors of plasma cells) may weaken bones, causing fractures. Fractured bones or weak or collapsed spinal bones, in turn, may place unusual pressure on nearby nerves, resulting in nerve pain, burning, or numbness and muscle weakness. Proteins produced by myeloma cells also may damage nerves.

Calcium from the destroyed bone enters the blood and urine, causing hypercalcemia, a medical condition in which abnormally high concentrations of calcium compounds exist in the bloodstream. High calcium affects nerve cell and kidney function. The symptoms of hypercalcemia include:

• weakness and fatigue
• depression
• mental confusion
• constipation
• increased thirst
• icreased urination
• nausea and vomiting
• kidney pain
• kidney failure

Hypercalcemia affects about one-third of multiple myeloma patients.

Serum proteins

The accumulation of M-proteins in the serum (the liquid portion of the blood) may cause additional complications, such as hyperviscosity syndrome, or thickening of the blood (though rare in multiple myeloma patients). Symptoms of hyperviscosity include:

• fatigue
• headaches
• shortness of breath
• mental confusion
• chest pain
• kidney damage and failure
• vision problems
• Raynaud's phenomenon

Poor blood circulation, or Raynaud's phenomenon, can affect any part of the body, but particularly the fingers, toes, nose, and ears.

Cryoglobulinemia occurs when the protein in the blood forms particles under cold conditions. These particles can block small blood vessels and cause pain and numbness in the toes, fingers, and other extremities during cold weather.

Amyloidosis is a rare complication of multiple myeloma. It usually occurs in individuals whose plasma cells produce only Ig light chains. These Bence-Jones proteins combine with other serum proteins to form amyloid protein. This starchy substance can invade tissues, organs, and blood vessels. In particular, amyloid proteins can accumulate in the kidneys, where they block the tiny tubules that are the kidney's filtering system. Indicators of amyloidosis include:

• carpal tunnel syndrome
• kidney failure
• liver failure
• heart failure