Jaundice is a condition in which a person's skin and the whites of the eyes are discolored yellow due to an increased level of bile pigments in the blood resulting from liver disease. Jaundice is sometimes called icterus, from a Greek word for "the condition."
In order to understand jaundice, it is useful to know about the role of the liver in producing bile. The most important function of the liver is the metabolic processing of chemical waste products like cholesterol, and excreting them into the intestines as bile. The liver is the premier chemical factory in the body—most incoming and outgoing chemicals pass through it. It is the first stop for all nutrients, toxins, and drugs absorbed by the digestive tract. The liver also collects chemicals from the blood for processing. Many of these outward bound chemicals are excreted into the bile. One particular substance, bilirubin, is yellow. Bilirubin is a product of the breakdown of hemoglobin, which is the protein inside red blood cells. If bilirubin cannot leave the body, it accumulates and discolors other tissues. The normal total level of bilirubin in blood serum is between 0.2 mg/dL and 1.2 mg/dL. When it rises to 3 mg/dL or higher, the person's skin and the whites of the eyes become noticeably yellow.
Bile is formed in the liver. It then passes into the network of hepatic bile ducts, which join to form a single tube. A branch of this tube carries bile to the gallbladder, where it is stored, concentrated, and released on a signal from the stomach. Food entering the stomach is the signal that stimulates the gallbladder to release the bile. The tube, which is called the common bile duct, continues to the intestines. Before the common bile duct reaches the intestines, it is joined by another duct from the pancreas. The bile and the pancreatic juice enter the intestine through a valve called the ampulla of Vater. After entering the intestine, the bile and pancreatic secretions together help in the process of digestion.
Causes & symptoms
There are many different causes for jaundice, but they can be divided into three categories based on where they start—before (pre-hepatic), in (hepatic), or after (post-hepatic) the liver. When bilirubin begins its life cycle, it cannot be dissolved in water. Thus, the liver changes it so that it is soluble in water. These two types of bilirubin are called unconjugated (insoluble) and conjugated (soluble). Blood tests can easily distinguish between these two types of bilirubin.
Hemoglobin and bilirubin formation
Bilirubin begins as hemoglobin in the blood-forming organs, primarily the bone marrow. If the production of red blood cells (RBCs) falls below normal, the extra hemoglobin finds its way into the bilirubin cycle and adds to the pool.
Once hemoglobin is in the red cells of the blood, it circulates for the life span of those cells. The hemoglobin that is released when the cells die is turned into bilirubin. If for any reason the RBCs die at a faster rate than usual, then bilirubin can accumulate in the blood and cause jaundice.
Hemolytic diseases are treated, if at all, with medications and blood transfusions, except in the case of an enlarged spleen. Surgical removal of the spleen (splenectomy) can sometimes cure hemolytic anemia. Drugs that cause hemolysis or arrest the flow of bile must be stopped immediately.
Normal jaundice in newborns
Normal newborn jaundice is the result of two conditions occurring at the same time—a prehepatic and a hepatic source of excess bilirubin. First of all, the baby at birth immediately begins converting hemoglobin from a fetal type to an adult type. The fetal type of hemoglobin was able
In 2002 new studies found that infants younger than eight weeks old with jaundice often had hidden (asymptomatic) urinary tract infections. Previous studies have shown that newborn jaundice may be an early sign of bacterial infections in infants. The study recommended that pediatricians routinely test young infants with jaundice for urinary tract infections.
Most liver diseases have no specific cure, but the liver is so robust that it can heal from severe damage and regenerate itself from a small remnant of its original tissue.
Post-hepatic forms of jaundice include the jaundices caused by failure of soluble bilirubin to reach the intestines after it has left the liver. These disorders are called obstructive jaundices. The most common cause of obstructive jaundice is the presence of gallstones in the ducts of the biliary system. Other causes have to do with birth defects and infections that damage the bile ducts; drugs; infections; cancers; and physical injury. Some drugs—and pregnancy on rare occasions—simply cause the bile in the ducts to stop flowing.
Symptoms and complications associated with jaundice
Certain chemicals in bile may cause itching when too much of them end up in the skin. In newborns, insoluble bilirubin may get into the brain and do permanent damage. Long-standing jaundice may upset the balance of chemicals in the bile and cause stones to form. Apart from these potential complications and the discoloration of skin and eyes, jaundice by itself is inoffensive. Other symptoms are determined by the disease producing the jaundice.
In many cases, the diagnosis of jaundice is suggested by the appearance of the patient's eyes and complexion. The doctor will ask the patient to lie flat on the examining table in order to feel (palpate) the liver and spleen for enlargement and to evaluate any abdominal pain. The location and severity of abdominal pain and the presence or absence of fever help the doctor to distinguish between hepatic and obstructive jaundice.
Disorders of blood formation can be diagnosed by more thorough examination of the blood or the bone marrow, where blood is made. Occasionally a bone marrow biopsy is required, but usually the blood itself will reveal the diagnosis. The spleen can be evaluated by an ultrasound examination or a nuclear scan if the physical examination has not yielded enough information.
Disease in the biliary system can be identified by imaging techniques, of which there are many. X rays are taken a day after swallowing a contrast agent that is secreted into the bile. This study gives functional as well as anatomical information. There are several ways of injecting x-ray dye directly into the bile ducts. It can be done through a thin needle pushed straight into the liver, or through a scope passed through the stomach that can inject dye into the ampulla of Vater. CT and MRI scans are very useful for imaging certain conditions, such as cancers in and around the liver, or gallstones in the common bile duct.
Liver disease is usually assessed from blood studies alone, but again a biopsy may be necessary to clarify less obvious conditions. A liver biopsy is performed at the bedside. The doctor uses a thin needle to take a tiny core of tissue from the liver. The tissue sample is sent to the laboratory for examination under a microscope.
Assessment of jaundice in newborns
Newborns are more likely to have problems with jaundice if:
- They are premature.
- They are of Asian or Native American descent.
- They have been bruised during the birth process.
- They have lost too much weight during the first few days.
- They are born at a high altitude.
- The mother has diabetes.
- Labor had to be induced.
In 2003, research was continuing to find noninvasive methods to determine bilirubin levels in newborns so
Jaundice is often an early warning sign of serious liver damage. Alternative medicine treatments should not be used as a substitute for conventional medical treatment. Patients should contact their doctors for diagnosis and treatment immediately if experiencing signs and symptoms of jaundice. Alternative therapies may be helpful as complementary measures for patients who have an underlying disease that already has been diagnosed.
Naturopaths or nutritionists may recommend the following dietary changes:
- Drinking fresh vegetable or fruit juices during the first several weeks after diagnosis and eating a diet consisting mostly of raw fruits and vegetables, seeds, and nuts during the next month. These fruits and vegetables are easy to digest and contain lots of antioxidants, vitamins and minerals. They help the body remove toxins from the blood, and decrease stress/strain on the liver for digestion/metabolism.
- Fasting intermittently.
- Eliminating alcohol from the diet for good, and avoiding foods that are processed and high in fat. These foods are bad for the liver.
- Drinking a cup of lemonade (without sugar) early in the morning to improve liver and bile function.
- Incorporating olive oil or lemon oil into the diet as a liver flushing regimen.
- Taking nutritional supplements, such as multivitamins or minerals, vitamin C, vitamin B complex, other antioxidant-containing supplements, supplements containing alpha lipoic acid, protein supplements, essential fatty acids (EFAs), and digestive enzymes with bile (for patients having pale stools).
Traditional Chinese medicine
Depending on a patient's specific condition, an expert Chinese herbalist may prescribe herbal remedies that can help improve liver function. Animal studies have shown the following Chinese herbs may have liver protective effects:
- Bupleurum chinense
- Phellodendron wilsonii
- Clementis chinensis
For homeopathic therapy, patients should consult a homeopathic physician who will prescribe specific remedies based on knowledge of the underlying cause.
Juice therapy helps the liver detoxify toxins to be eliminated from the body. Patients should mix one part of pure juice with one part of water before drinking. Daily consumption of the following juices may be helpful:
- carrot and beet juice with a touch of radish or dandelion root juice
- grapes, pear, and lemon
- carrot, celery, and parsley
- carrot, beet, and cucumber
Essential oils of rosemary, lemon, and geranium may help improve liver function and relax the body. They can be given as inhalants, a soothing bath, or soak.
Jaundice in newborns
Newborns are the only major category of patients in whom the jaundice itself requires attention. If there is reason to suspect increased hemolysis in the newborn, the bilirubin level must be measured repeatedly during the first few days of life. If the level of bilirubin shortly after birth threatens to go too high, treatment must begin immediately. Exchanging most of the baby's blood was the only way to reduce the amount of bilirubin until a few decades ago. Jaundiced babies are now fitted with eye
Obstructive jaundice frequently requires a surgical cure. If the original passageways cannot be restored, surgeons have several ways to create alternate routes. To create alternate passageways, a surgeon will sew an open piece of intestine over a bare patch of liver. Tiny bile ducts in that part of the liver will begin to discharge their bile into the intestine, and pressure from the obstructed ducts elsewhere will find release in that direction. As the flow increases, the ducts grow to accommodate it. Soon, all the bile is redirected through the open pathways.
Erythroblastosis fetalis can be prevented by giving an Rh-negative mother a gamma globulin solution called RhoGAM whenever there is a possibility that she is developing antibodies to her baby's blood. G6PD hemolysis can be prevented by testing patients before giving them drugs that can cause it. Medication side effects can be minimized by early detection and immediate cessation of the drug. Malaria can often be prevented by taking certain precautions when traveling in tropical or subtropical countries. These precautions include staying in after dark; using such prophylactic drugs as mefloquine; and protecting sleeping quarters with mosquito nets treated with insecticides and mosquito repellents. In 2003, new studies showed promise for a possible vaccine against malaria. Early trials showed that vaccination combination might stimulate T-cell activity against malaria, the best type of protection that researchers can hope to find. However, further studies will have to be done.
New research in 2002 linked a popular antidepressant drug called paroxetine (Paxil) to several newborn complications, including jaundice. Although research is preliminary, pregnant women might want to discuss use
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American Liver Foundation. 1425 Pompton Avenue, Cedar Grove, New Jersey 07009. (800) 223–0179.
Teresa G. Odle
Table Of Contents
- Causes & symptoms
- Hemoglobin and bilirubin formation
- Hemolytic disorders
- Normal jaundice in newborns
- Hepatic jaundice
- Post-hepatic jaundice
- Symptoms and complications associated with jaundice
- Physical examination
- Laboratory tests
- Imaging studies
- Assessment of jaundice in newborns
- Nutritional therapy
- Traditional Chinese medicine
- Herbal therapy
- Juice therapy
- Other therapies
- Jaundice in newborns
- Posthepatic jaundice