Hypersensitivity Pneumonitis Health Article

Definition

Hypersensitivity pneumonitis refers to an inflammation of the lungs caused by repeated breathing in of a foreign substance, such an organic dust, a fungus, or a mold. The body's immune system reacts to these substances, called antigens, by forming antibodies, molecules that attack the invading antigen and try to destroy it. The combination of antigen and antibody produces acute inflammation, or pneumonitis (a hypersensitivity reaction), which later can develop into chronic lung disease that impairs the lungs' ability to take oxygen from the air and eliminate carbon dioxide.

Description

Hypersensitivity pneumonitis (HP) is sometimes called "allergic alveolitis." "Allergic" refers to the antigen-antibody reaction, and "alveolitis" means an inflammation of the tiny air sacs in the lungs where oxygen and CO₂ are exchanged, the alveoli. It also is known as "extrinsic" allergic alveolitis, meaning that the antigen that sets up the allergic reaction (also called an allergen) comes from the outside. Most of the antigens that cause this disease come from plant or animal proteins or microorganisms, and many of those affected are exposed either at work or in the course of some hobby or other activity. The first known type of HP, farmer's lung, is caused by antigens from tiny microorganisms living on moldy hay. An example of disease connected with a hobby is pigeon breeder's lung, caused by inhaling protein material from bird droppings or feathers. After a time, very little of the allergenic material is needed to set off a reaction in the lungs.

Roughly one in every 10,000 persons develops some form of HP. A mysterious aspect of this condition is that, even though many persons may be exposed to a particular antigen, only a small number of them will develop the disease. Genetic differences may determine who becomes ill; this remains unclear. Probably between 5% and 15% of all persons who are regularly exposed to organic materials develop HP. Most of those who do get it do not smoke (smoking may create the type of cells that take up antigens and neutralize them). The amount of antigen is an important factor in whether HP will develop and what form it will take. Sudden heavy exposure can produce symptoms in a matter of hours, whereas mild but frequent exposures tend to produce a long-lasting, "smoldering" illness. HP may be more likely to develop in persons exposed to polluted air or industrial fumes.

Typical changes occur in the lungs of persons with HP. In the acute stage, large numbers of inflammatory cells are found throughout the lungs and the air sacs may be filled by a thick fluid mixed with these cells. In the subacute stage, disease extends into the small breathing tubes, or bronchioles, and the inflammatory cells collect into tiny granules called granulomas. Finally, in the chronic stage of HP, the previously inflamed parts of the lungs become scarred and unable to function, as in pulmonary fibrosis.

Causes and symptoms

A number of different types of HP are known, since a wide range of allergens may produce an allergic reaction in the lungs. Many of them produce similar symptoms and abnormal physical findings, but some have their own typical features. Some of the more common forms are:

• Farmer's lung. Can affect any farmer who works with wet hay or other moldy dust. Small farmers who have to directly thresh and handle their hay are most at risk, as are those living in cold and humid areas where damp weather is common.
• Pigeon breeder's lung. Also called "bird fancier's lung," it is second to farmer's lung as the best known type of HP. A substance has been found in pigeon droppings that may cause the allergic reaction, but there may be more than one such substance. Besides pigeons, the disorder may follow exposure to ducks, geese, pheasants, and even canaries. Parakeets produce an especially severe form of disease. Most patients are middle-aged women, who usually care for birds either at home or on bird breeding farms.
• Bagassosis. Caused by bagasse, a substance produced when juice is extracted from sugar cane and is used in making paper and explosives. A fungus is probably responsible. Young and middle-aged men who work in the sugar industry are at risk.
• Byssinosis. A similar condition affecting workers who inhale dust from cotton, flax, or hemp.
• Humidifier lung. An acute form of HP caused by inhaling actinomycyetes, the same organisms that cause farmer's lung, which grow in contaminated humidifier vents, air conditioners, heating systems, and even saunas.
• Other antigens. HP has been seen in persons working with detergents, silicone, mushrooms, cheese, wood dust, maple bark, coffee, and furs.

In the acute stage, patients with HP begin coughing, develop fever, and note tightness in the chest as well as extreme tiredness and aching, four to eight hours after the most recent exposure. Most patients are well aware of the connection between their work (or an activity) and their symptoms. After a time, patients may have trouble breathing. They also may lose their appetite, lose weight, and generally feel ill. Finally, in the chronic stage, the patient will have increasing trouble breathing and may sometimes wheeze. With advanced disease, the skin may appear bluish (because too little oxygen is getting into the blood). When the physician listens to the patient's chest with a stethoscope, there may be crackling sounds or loud wheezing. In the late stages, club-shaped fingertips are a sign that the patient has not been getting enough oxygen for an extended period of time.