Extracorporeal Membrane Oxyge... Health Article

Definition

Extracorporeal membrane oxygenation (ECMO) is a special procedure that uses an artificial heart-lung machine to take over the work of the lungs (and sometimes also the heart). ECMO is used most often in newborns and young children, but it also can be used as a last resort for adults whose heart or lungs are failing.

Purpose

In newborns, ECMO is used to support or replace an infant's undeveloped or failing lungs by providing oxygen and removing carbon dioxide waste products so the lungs can rest. Infants who need ECMO may include those with:

• meconium aspiration syndrome (breathing in of a newborn's first stool by a fetus or newborn, which can block air passages and interfere with lung expansion)
• persistent pulmonary hypertension (a disorder in which the blood pressure in the arteries supplying the lungs is abnormally high)
• respiratory distress syndrome (a lung disorder usually of premature infants that causes increasing difficulty in breathing, leading to a life-threatening deficiency of oxygen in the blood)
• congenital diaphragmatic hernia (the profusion of part of the stomach through an opening in the diaphragm).
• pneumonia
• blood poisoning

ECMO is also used to support a child or adult patient's damaged, infected, or failing lungs for a few hours to allow treatment or healing. It is effective for those patients with severe, but reversible, heart or lung problems who haven't responded to treatment with a ventilator, drugs, or extra oxygen. Adults and children who need ECMO usually have one of these problems:

• heart failure
• pneumonia
• respiratory failure caused by trauma or severe infection

The ECMO procedure can help a patient's lungs and heart rest and recover, but it will not cure the underlying disease. Any patient who requires ECMO is seriously ill and will likely die without the treatment. Because there is some risk involved, this method is used only when other means of support have failed.

Precautions

Typically, ECMO patients have daily chest x rays and blood work, and constant vital sign monitoring. They are usually placed on a special rotating bed that is designed to decrease pressure on the skin and help move secretions from the lungs.

After the patient is stable on ECMO, the breathing machine settings will be lowered to "rest" settings, which allows the lungs to rest without the risk of too much oxygen or pressure from the ventilator.

Description

There are two types of ECMO: Venoarterial (V-A) ECMO supports the heart and lungs, and is used for patients with blood pressure or heart functioning problems in addition to respiratory problems. Venovenous (VV) ECMO supports the lungs only.

V-A ECMO requires the insertion of two tubes, one in the jugular and one in the carotid artery. In the V-V ECMO procedure, the surgeon places a plastic tube into the jugular vein through a small incision in the neck.

Once in place, the tubes are connected to the ECMO circuit, and then the machine is turned on. The patient's blood flows out through the tube and may look very dark because it contains very little oxygen. A pump pushes the blood through an artificial membrane lung, where oxygen is added and carbon dioxide is removed. The size of the artificial lung depends on the size of the patient; sometimes adults need two lungs. The blood is then warmed and returned to the patient. A steady amount of blood (called the flow rate) is pushed through the ECMO machine every minute. As the patient improves, the flow rate is lowered.

Many patients require heavy sedation while they are on ECMO to lessen the amount of oxygen needed by the muscles.

As the patient improves, the amount of ECMO support will be decreased gradually, until the machine is turned off for a brief trial period. If the patient does well without ECMO, the treatment is stopped.

Typically, newborns remain on ECMO for three to seven days, although some babies need more time (especially if they have a diaphragmatic hernia). Once the baby is off ECMO, he or she will still need a ventilator (breathing machine) for a few days or weeks. Adults may remain on ECMO for days to weeks, depending on the condition of the patient, but treatment may be continued for a longer time depending on the type of heart or lung disease, the amount of damage to the lungs before ECMO was begun, and the presence of any other illnesses or health problems.

Preparation

Before ECMO is begun, the patient receives medication to ease pain and restrict movement.

Aftercare

Because infants on ECMO may have been struggling with low oxygen levels before treatment, they may be at higher risk for developmental problems. They will need to be monitored as they grow.