Diethylstilbestrol diphosphate is a synthetic (manufactured) form of the female hormone estrogen. Brand names for diethylstilbestrol include Stilphostrol, and is also referred to as Stilbestrol and DES.
Purpose
Diethylstilbestrol is used to relieve symptoms of advanced breast cancer that has metastasized, or spread, from the breast to other parts of the body. It is used to treat breast cancer in men and in postmenopausal women. Diethylstilbestrol also has been used to relieve symptoms of advanced cancer of the prostate in men.
Description
Diethylstilbestrol was the first form of estrogen made in the laboratory. It was prescribed to millions of women in the 1950s and 1960s to prevent miscarriage and premature birth. This use was discontinued in the 1970s, when abnormalities of the reproductive systems were found in some children of women who took the drug during pregnancy. Furthermore, daughters of women who took this drug during pregnancy are at an increased risk for developing certain types of cervical and vaginal cancers.
Diethylstilbestrol is used to relieve some symptoms of advanced breast cancer in certain men and women. The drug can interfere with the spread of cancer cells that require estrogen to grow and divide.
Diethylstilbestrol sometimes is used to relieve symptoms of advanced prostate cancer in men. This drug can lower the levels of the male hormone testosterone, which is required for the growth and division of these cancer cells. However, diethylstilbestrol can cause severe side effects in men, including breast enlargement and increased risk of heart disease and blood clots. Thus, it is no longer widely used for the treatment of prostate cancer.
Recommended dosage
Diethylstilbestrol usually is given as a pill, which should be taken at the same time each day. The dosage varies depending on body weight and the type of cancer that is being treated. For breast cancer, the dose is 15 mg per day.
For inoperable prostate cancer, the dose is 50 mg three times a day and can be increased up to 200 mg or more three times a day. Maximum dose is 1 gram a day. For the treatment of prostate cancer, diethylstilbestrol can also be injected slowly into a vein. The dosage may be as high as 1 gram per day for five or more days. The dosage then may be lowered to 250-500 mg once or twice per week.
Precautions
Diethylstilbestrol can cause serious birth defects in humans. Children of women who take diethylstilbestrol (DES) during pregnancy may develop reproductive system abnormalities at puberty, and daughters are at an increased risk for developing vaginal cancer. Therefore, this drug should not be taken by pregnant women, or by either the man or the woman at the time of conception. Women should not breast-feed infants while taking this drug, since estrogens pass into the breast milk.
Diethylstilbestrol may not be indicated, or should be used with caution, for individuals whose medical histories include any of the following:
Diethylstilbestrol affects normal cells as well as cancer cells, so side effects can occur with this medicine. The side effects associated with diethylstilbestrol usually are mild and temporary. Common side effects include:
enlargement of the breasts
breast tenderness
decreased sexual desire
voice changes
swelling of the feet and lower legs
fluid retention
weight gain
Less common side effects of diethylstilbestrol include:
nausea and vomiting during the first few weeks of treatment
Taking the medicine with food may reduce or prevent nausea.
Rarely, diethylstilbestrol results in the formation of blood clots in the legs or in the lungs. This primarily affects men who are receiving high-dosage treatment for breast or prostate cancers. Symptoms of blood clots include:
pain, redness, or swelling in the calf
weakness or tingling in an arm or leg
faintness
sudden severe headache
vision changes
shortness of breath
chest pain
coughing up blood (hemoptysis)
Interactions
Medicines that may adversely affect the liver when taken along with diethylstilbestrol include:
In addition, diethylstilbestrol and other estrogens can prevent cyclosporine (Sandimmune) from being removed from the body, leading to possible kidney or liver problems. Protease inhibitors such as ritonavir (Norvir) may reduce the activity of diethylstilbestrol.
