Antiemetic drugs are drugs used to combat nausea and vomiting.
Purpose
Antiemetic drugs are used to prevent vomiting (emesis) in chemotherapy patients and postoperative patients. Aside from the difficulty of maintaining proper nutrition and a healthy weight, chronic vomiting can result in dehydration, which can be a medical emergency. Following are descriptions of antiemetic drugs in use as of 2001.
Description
Promethazine
Promethazine is also known as phenergan and mepergan. It is also used to treat motion sickness, reduce allergic symptoms, and for sedation. It is one of the drugs of the phenothiazine type. In addition to other qualities, it is an antihistamine.
The serotonin receptor antagonists include granisetron (kytril), dolasetron (anzemet), and ondansetron (zofran). These drugs are used for postoperative nausea and emesis as well as nausea and vomiting associated with chemotherapy, and are often used in combination with a corticosteroid. Ondansetron is approved for nausea and vomiting associated with radiation therapy.
Dronabinol
Dronabinol (marinol) is used to combat anorexia in AIDS patients, and emesis in cancer patients who haven't responded to other antiemetics. Marinol is the synthetic or extracted form of the active ingredient found in marijuana.
Other antipsychotic (neuroleptic) drugs
The other neuroleptic (antipsychotic) drugs used to treat nausea and emesis are droperidol (inapsine), haloperidol (haldol), chlorpromazine (thorazine), and perphenazine (trilafon). One other antipsychotic, triethylperazine (torecan or norzine), was used as an antiemetic, but is no longer widely available. Some of the antipsychotics are also used to treat aggressive or violent behavior or intractable hiccups (chlorpromazine). These drugs are similar to prochlorperazine in terms of their actions and potentially severe side effects.
There are some additional precautions and side effects associated with each of these drugs. Patients should be sure to notify their physician of any health concerns (including pregnancy) or medications they are taking. Patients should also ask about potential side effects for each individual medication before receiving any of these drugs.
Dosage
Promethazine
Promethazine is given in doses of 12.5 to 25 mg every 4 hours if injected into the muscle or as a suppository. As a syrup, 25 mg should be given every 4 to 6 hours. Doses for children vary by age, weight, and severity of condition.
Prochlorperazine
Generally, the dose is 5 to 10 mg, 3 to 4 times per day. However, the effect of medication varies widely from patient to patient, so the dose should be tailored to each individual. Prochlorperazine is available as a syrup, tablet, 25 mg slow-release capsule, and in injectable form.
Dronabinol
The effective dose of dronabinol varies widely from patient to patient and should be monitored and tested by the physician. The basic dose is 5mg/m 2 given 4 to 6 times per day.
Precautions
Promethazine
Patients with cardiovascular disease or impaired liver function should either use this drug with caution or not at all. Children should also use this drug cautiously for two reasons. First, some side effects may suggest, or mask, underlying disease, such as Reye's syndrome. Second, large doses of this drug, or any antihistamine, may cause convulsions, hallucinations, or death in children. Patients taking this medication should not drive, operate heavy machinery, or engage in any hazardous activity while under the influence of this drug. This drug has not been established as safe for use during pregnancy, or in nursing mothers.
Prochlorperazine
Persons allergic to any other phenothiazine (such as promethazine) should not take prochlorperazine. Patients who have heart problems, glaucoma or bone marrow depression should take this drug with caution, or not at all, and inform their physician of their condition. Persons who will be around high temperatures should also avoid this drug. In addition, persons who experience seizures should be aware that administration of this drug makes seizures more likely.
Breast cancer patients may wish to avoid this drug because it increases levels of prolactin in the blood. Increased prolactin may help some types of breast cancer to thrive.
Prochloroperazine, like promethazine, may mask symptoms of Reye's disease in children. It may also mask symptoms of intestinal obstructions or brain disease. In addition, children who are acutely ill, under two years of age, or under 20 pounds should not be given this drug.
This drug has not been established as safe for use during pregnancy and is found in the breast milk of lactating mothers. Therefore, caution should be used when administering this drug to pregnant women and extreme caution should be used when administering to nursing women.
Serotonin receptor antagonists
Patients with allergies to any drug in this category should not take any other drug in this category. Also, patients with hypokalemia, hypomagnesia, or certain heart problems should avoid taking these drugs. The effect of these drugs on the children or fetuses of nursing or pregnant mothers is not known, so they should be used with caution.
Dronabinol
Dronabinol is inadvisable for patients with a known allergy to either sesame oil or any part of the cannabis plant. Patients taking this drug should not drive, operate heavy machinery, or engage in hazardous tasks until used to this medication.
This medication also should be used cautiously, if at all, for persons with depression, mania, or schizophrenia, elderly patients, patients with cardiac disorders, and for pregnant and nursing women. It is especially inadvisable for nursing women, since marinol is concentrated in the breast milk.
Side effects
Promethazine
Patients taking promethazine may experience a large number of side effects, including drowsiness, ringing in the ears, a lack of coordination, problems with vision, fatigue, euphoria, nervousness, tremors, seizures, a cata-tonic-like state, and hysteria. These effects are usually reversible. At high doses, patients may also exhibit extrapyramidal reactions. Extrapyramidal reactions can briefly be described as agitation (jitteriness, sometimes insomnia), muscle spasms, and/or pseudo-Parkinson's (a group of symptoms including, but not limited to, drooling, tremors, and a shuffling gait).
Patients may also experience rashes, asthma, jaundice, abnormally low production of white blood cells, and abnormalities in how fast or slow their heart beats. Patients may sometimes experience unusual side effects not known as typical for the medication they are taking. These should be reported to the physician.
Prochlorperazine
Prochlorperazine has many side effects, including low blood pressure, dizziness, blurred vision, skin reactions, jaundice, lack of production of white cells, damage to the DNA in sperm, problems in the regulation of body temperature, impotence, amenorrhea (a lack of menstruation), and gynecomastia (the growth of female-like breasts in males). However, the most severe side effects stem from damage to the brain. Patients may suffer from extrapyramidal reactions. These symptoms may be reversed by treating the patient with drugs effective in treatment of Parkinson's patients (except levodopa). A reduction or elimination in the amount of the antipsychotic medication may also be necessary to eliminate these symptoms.
Two other (rare) disorders, tardive dyskinesia and neuroleptic malignant syndrome (NMS), are also associated with antipsychotic drug use. Patients with NMS have high temperatures, rigid muscles, an altered mental state, and symptoms such as excessive sweating and irregular blood pressure or heart rhythm. Patients with NMS usually respond to treatment. Patients with tardive dyskinesia have involuntary movement of muscles in the chest, arms, and legs, or in the muscles in and around the face (including the tongue). Tardive dyskinesia may be irreversible.
Serotonin receptor antagonists
Side effects include rashes, increased sweating, problems with taste or vision, flushing, agitation, sleep disorder, depersonalization, headache, fatigue, nausea, weakness, abdominal pain, constipation, diarrhea, hypertension, dizziness, chills and shivering, and dry mouth. Patients may also have abnormal liver function tests.
Dronabinol
Possible side effects are fatigue, weakness, abdominal pain, nausea, vomiting, heart palpitations, fast heart rate, facial flushing, amnesia, anxiety, an abnormal mental state, depersonalization, confusion, dizziness, and euphoria.
Interactions
Promethazine
Promethazine interacts with central nervous system depressants, like alcohol and barbiturates. Therefore, the physician should alerted to any medications the patient is taking, and doses of the drugs should be adjusted accordingly. Alcohol should be avoided. It has not been proven, but promethazine may interfere with the action of epinephrine.
Prochlorperazine
Like promethazine, prochlorperazine should be used cautiously, or not at all, with central nervous system depressants like alcohol and barbiturates. Prochlorperazine has also been shown to interact with anticonvulsant medication, guanethidene, propanolol, thiazide diuretics, and oral anticoagulants (like warfarin and coumadin).
Serotonin receptor antagonists
These drugs may have very negative effects on the patient when combined with diuretics, anti-arrhythmia drugs, or high doses of anthracycline.
Dronabinol
Dronabinol interacts with the antiemetic prochlorperazine synergistically. Therefore, the use of these two
drugs in combination results in a greater antiemetic effect. Patients taking central nervous system depressants, such as barbiturates or alcohol should notify their physician before taking marinol, since marinol may increase their effect. Although no drugs have been shown to interact with marinol, many drugs similar to marinol do interact with a number of other drugs, including central nervous system depressants such as alcohol or barbiturates, or drugs like flouxetine or disulfiram. Again, the physician should alerted to any medications the patient is taking before beginning a course of dronabinol.
