Adult Respiratory Distress Sy... Health Article

Definition

Adult respiratory distress syndrome (ARDS), also called acute respiratory distress syndrome, is a type of lung (pulmonary) failure that may result from any disease that causes large amounts of fluid to collect in the lungs. ARDS is not itself a specific disease, but a syndrome, a group of symptoms and signs that make up one of the most important forms of lung or respiratory failure. It can develop quite suddenly in persons whose lungs have been perfectly normal. Very often ARDS is a true medical emergency. The basic fault is a breakdown of the barrier, or membrane, that normally keeps fluid from leaking out of the small blood vessels of the lung into the breathing sacs (the alveoli).

Description

Another name for ARDS is shock lung. Its formal name is misleading, because children, as well as adults, may be affected. In the lungs the smallest blood vessels, or capillaries, make contact with the alveoli, tiny air sacs at the tips of the smallest breathing tubes (the bronchi). This is the all-important site where oxygen passes from air that is inhaled to the blood, which carries it to all parts of the body. Any form of lung injury that damages this point of contact, called the alveolo-capillary junction, will allow blood and tissue fluid to leak into the alveoli, eventually filling them so that air cannot enter. The result is the type of breathing distress called ARDS. ARDS is one of the major causes of excess fluid in the lungs, the other being heart failure.

Along with fluid there is a marked increase in inflamed cells in the lungs. There also is debris left over from damaged lung cells, and fibrin, a semi-solid material derived from blood in the tissues. Typically these materials join together with large molecules in the blood (proteins), to form hyaline membranes. (These membranes are very prominent in premature infants who develop respiratory distress syndrome; it is often called hyaline membrane disease.) If ARDS is very severe or lasts a long time, the lungs do not heal, but rather become scarred, a process known as fibrosis. The lack of a normal amount of oxygen causes the blood vessels of the lung to become narrower, and in time they, too, may become scarred and filled with clotted blood. The lungs as a whole become very "stiff," and it becomes much harder for the patient to breathe.

Causes and symptoms

A very wide range of diseases or toxic substances, including some drugs, can cause ARDS. They include:

• Breathing in (aspiration) of the stomach contents when regurgitated, or salt water or fresh water from nearly drowning.
• Inhaling smoke, as in a fire; toxic materials in the air, such as ammonia or hydrocarbons; or too much oxygen, which itself can injure the lungs.
• Infection by a virus or bacterium, or sepsis, a widespread infection that gets into the blood.
• Massive trauma, with severe injury to any part of the body.
• Shock with persistently low blood pressure may not in itself cause ARDS, but it can be an important factor.
• A blood clotting disorder called disseminated intravascular coagulation, in which blood clots form in vessels throughout the body, including the lungs.
• A large amount of fat entering the circulation and traveling to the lungs, where it lodges in small blood vessels, injuring the cells lining the vessel walls.
• An overdose of a narcotic drug, a sedative, or, rarely, aspirin.
• Inflammation of the pancreas (pancreatitis), when blood proteins, called enzymes, pass to the lungs and injure lung cells.
• Severe burn injury.
• Injury of the brain, or bleeding into the brain, from any cause may be a factor in ARDS for reasons that are not clear. Convulsions also may cause some cases.

Usually ARDS develops within one to two days of the original illness or injury. The person begins to take rapid but shallow breaths. The doctor who listens to the patient's chest with a stethoscope may hear "crackling" or wheezing sounds. The low blood oxygen content may cause the skin to appear mottled or even blue. As fluid continues to fill the breathing sacs, the patient may have great trouble breathing, take very rapid breaths, and gasp for air.