Acrocallosal Syndrome

Treatment and management

Beginning in infancy, physical therapy may assist in the development of motor skills and muscle tone. Surgery to remove extra fingers and release fused fingers may improve movement and grasp, though the muscle tone may remain poor. Surgery to separate or remove affected toes may assist in walking and the comfort of footwear. Anti-epileptic therapy should be considered if a seizure disorder develops. Special education may be required, depending on the level of mental impairment.

Prognosis

At present, there are no preventative measures for acrocallosal syndrome, and the severity of symptoms and outcomes varies by individual. It has been found that the lifestyle of an individual with acrocallosal syndrome is dependent upon the degree of mental retardation and reduced muscle tone, rather than the extent of facial and limb malformations.

PERIODICALS

Bonatz, E., et al. "Acrocallosal Syndrome: A Case Report." The Journal of Hand Surgery 22A (1997): 492-494.

Fryns, J. P., et al. "Polysyndactyly and Trignocephaly with Partial Agenesis of the Corpus Callosum: An Example of the Variable Clinical Spectrum of the Acrocallosal Syndrome?" Clinical Dysmorphology 6 (1997): 285-286.

Fryns, J. P., et al. "The Variable Clinical Spectrum and Mental Prognosis of the Acrocallosal Syndrome." Journal of Medical Genetics 28, no. 23 (March 1991): 214-215.

Hendriks, H.J.E., et al. "Acrocallosal Syndrome." American Journal of Medical Genetics 35 (1990): 443-446.

Schinzel, A., and U. Kaufmann. "The Acrocallosal Syndrome in Sisters." Clinical Genetics 30 (1986): 339-405.

Thyen, U., et al. "Acrocallosal Syndrome: Association with Cystic Malformation of the Brain and Neurodevelopmental Aspects." Neuropediatrics 23 (1992): 292-296.

ORGANIZATIONS

Agenesis of the Corpus Callosum (ACC) Network. Merrill Hall, University of Maine, Room 18, 5749, Orono, ME 04469-5749. (207) 581-3119. um-acc@maine.edu.

WEBSITES

About Face U.S.A. <http://www.aboutface2000.org>.

FACES: The National Craniofacial Association. <http://www.faces-cranio.org>.

Maureen Teresa Mahon, BS, MFS