Generic Name: vorinostat, Oral capsule

Zolinza

All Brands

  • Zolinza
SECTION 1 of 4

Highlights for vorinostat

Oral capsule
1
VORINOSTAT (vor IN oh stat) is a chemotherapy drug. It is used to treat cutaneous T-cell lymphoma (CTCL).
2 3 4
Talk to your healthcare provider if you have any of these conditions.
5
Know what to watch for and get tips for reducing your risks while taking this drug.
SECTION 2 of 4

vorinostat Side Effects

Oral capsule

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • breathing problems
  • change in the amount of urine
  • chest pain
  • cough
  • fast, irregular heartbeat
  • feeling faint or lightheaded, falls
  • fever or chills, sore throat
  • increased hunger or thirst
  • pain, swelling, warmth in the leg
  • problems with balance, talking, walking
  • swelling of feet, legs
  • unusual bleeding or bruising
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • changes in taste
  • constipation
  • diarrhea
  • dry mouth
  • headache
  • loss of appetite
  • muscle aches
  • nausea, vomiting
  • stomach upset
SECTION 3 of 4

vorinostat May Interact with Other Medications

Oral capsule

Do not take this medicine with any of the following medications:

  • chlorpromazine
  • cisapride
  • grepafloxacin
  • halofantrine
  • hawthorn
  • pimozide
  • sparfloxacin
  • thioridazine
  • ziprasidone

This medicine may also interact with the following medications:

  • alfuzosin
  • chloroquine
  • cyclobenzaprine
  • droperidol
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for irregular heart beat
  • medicines for nausea/vomiting like dolasetron, ondansetron, palonosetron
  • medicines for numbness or sleep during surgery
  • medicines that treat or prevent blood clots like enoxaparin, heparin, ticlodipine, warfarin
  • other cancer treatments like dasatinib, lapatinib
  • methadone
  • octreotide
  • pentamidine
  • prochlorperazine
  • propafenone
  • some antibiotics like clarithromycin, erythromycin, levofloxacin, mefloquine
  • tacrolimus
  • valproic acid
  • vardenafil
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
SECTION 4 of 4

How to Use vorinostat

Oral capsule

Take this medicine by mouth with a glass of water. Follow the directions on the prescription label. Take this medicine with food. Do not chew, crush, or open the capsules. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • diabetes
  • history of blood clots
  • history of irregular heartbeat
  • liver disease
  • take medicines that treat or prevent blood clots
  • an unusual or allergic reaction to vorinostat, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

Visit your doctor for regular check ups. Report any side effects. You will need blood work done while you are taking this medicine.

Talk to your doctor about how many glasses of water to drink each day. It is important to drink plenty of fluids and to avoid dehydration.

If the capsules of this medicine is broken or opened, do not touch the capsules or the powder contents of the capsules. If the powder gets on your skin or in your eyes, wash the area well with plenty of water. Call your doctor.

Do not become pregnant while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information. Do not breast-feed an infant while taking this medicine.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.

Send us your feedback

Thank you.

Your message has been sent.

We're sorry, an error occurred.

We are unable to collect your feedback at this time. However, your feedback is important to us. Please try again later.

Last Updated: November 6, 2012

The Healthline Site, its content, such as text, graphics, images, search results, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.
Content licensed by
Gold Standard Logo

Healthline - Gold Standard License

Terms of Use

Licensee provides access to Alchemy provided by Gold Standard, Inc. ("Gold Standard"). Although Gold Standard makes reasonable efforts to ensure the accuracy and reliability of Alchemy, End User acknowledges and agrees that Licensee, its affiliates, and their respective officers, directors, employees and information providers and Gold Standard, its affiliates, its licensors, and their respective officers, directors, employees and information providers will not be held liable for any damages suffered or incurred by End User or any third person arising out of: a) any faults, interruptions or delays in Alchemy or its delivery, b) any use of or reliance on Alchemy by any person, or c) any inaccuracies, errors or omissions in Alchemy, irrespective of however such faults, interruptions, delays, inaccuracies, errors or omissions arise. Gold Standard shall not be liable to End User for any loss, cost or damages resulting from any delays in delivery and/or non-delivery of Alchemy or its content. End User acknowledges and agrees that its sole and exclusive remedy in the event of such delay is to not accept these terms and conditions. Gold Standard does not represent or warrant that Alchemy will meet the objectives or needs of End User or any third party. Gold Standard makes no warranty of merchantability of Alchemy or of the fitness of Alchemy for any purpose.

About Gold Standard

The Gold Standard editorial staff develops clinically-based drug information content through an independent, peer-reviewed process. Content updates to the database include new FDA-approved drugs, new non-prescription and herbal therapies, newly published information regarding FDA label changes and relevant clinical studies affecting off-label utilization. Editors do not have any significant financial relationships with the industry that would introduce bias in the editing or review of database content.

Read This Next

7 Health Claims About Astaxanthin
7 Health Claims About Astaxanthin
Adderall and Weight Loss: What You Need to Know
Adderall and Weight Loss: What You Need to Know
6 Kinds of Natural Mosquito Repellent
6 Kinds of Natural Mosquito Repellent
Advertisement
Advertisement
Advertisement