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Generic Name:

trospium, Oral tablet

All Brands

  • Sanctura (Discontinued)
A discontinued drug is a drug that has been taken off the market due to safety issues, shortage of raw materials, or low market demand.
SECTION 1 of 5

Highlights for trospium

Oral tablet
1

Trospium is an oral drug that’s used to treat overactive bladder (OAB).

2

The dose of trospium immediate-release tablets is one 20-mg tablet taken by mouth two times per day. You should take it with water on an empty stomach, at least one hour before eating a meal. The dose for trospium extended-release capsules is one 60-mg capsule taken by mouth once per day in the morning. You should take it with water on an empty stomach, at least one hour before eating a meal.

3

You may not be able to take this drug if you have certain health problems. Let your doctor know if you have an allergy to trospium, trouble emptying your bladder, a weak urine stream, stomach problems, narrow-angle glaucoma, or liver or kidney problems. Also tell your doctor if you’re pregnant or breast-feeding.

4

This drug may cause blurred vision or dizziness and drowsiness. You shouldn’t drive, use machinery, or do similar tasks that require alertness until you know how trospium affects you. Alcohol can also make drowsiness and dizziness caused by trospium worse.

5

Common side effects include dry mouth, constipation, headache, and stomach pain.

IMPORTANT INFORMATION

Swelling (edema)

In rare cases, trospium may cause swelling of your face, lips, tongue, or throat. If swelling occurs and makes it hard for you to breathe, call 9-1-1 or go to the emergency room right away.

Heat exhaustion

Trospium may cause you to sweat less. Heat exhaustion can occur when trospium is used in a hot environment. Symptoms include:

  • cool, moist skin with goose bumps when you’re hot
  • sweating heavily
  • feeling faint
  • dizziness
  • tiredness
  • a weak but fast heart rate
  • lightheadedness caused by a drop in blood pressure when you stand up from a lying or sitting position (orthostatic hypotension)
  • muscle cramps
  • nausea
  • headache

What is trospium?

Trospium is a prescription drug. It’s available as an oral immediate-release tablet and oral extended-release capsule.

Trospium is only available as a generic drug.

Why it's used

Trospium is used to treat overactive bladder (OAB), which causes the following symptoms:

  • urge urinary incontinence: a strong need to urinate right away, with leaking or wetting accidents
  • urgency: a strong need to urinate right away
  • frequency: urinating more often than usual

How it works

Trospium belongs to a class of medications called urinary antagonists. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Overactive bladder is a condition where your bladder muscles contract involuntarily even when your bladder isn’t full.

More Details

How it works

Trospium belongs to a class of medications called urinary antagonists. A class of drugs refers to medications that work similarly. They have a similar chemical structure and are often used to treat similar conditions.

Overactive bladder is a condition where your bladder muscles contract involuntarily even when your bladder isn’t full. When they contract, you’ll feel the need to urinate right away. Trospium helps decrease and prevent these involuntary bladder contractions or spasms. This decreases your sudden need to urinate, having to urinate often, and leaking in between bathroom visits.

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SECTION 2 of 5

trospium Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with trospium include:

  • dry mouth

  • constipation

  • headache

  • stomach pain

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life-threatening or if you think you’re experiencing a medical emergency, call 9-1-1.

  • allergic reactions. Symptoms include:

    • hives
    • trouble breathing
    • swelling of your face, lips, tongue, or throat that may make it harder to breathe (angioedema)
  • psychiatric issues. Symptoms include:

    • hallucinations
    • confused thinking and not being as aware of your surroundings (delirium)
  • heat exhaustion. Symptoms include:

    • cool, moist skin with goose bumps when you’re hot
    • sweating heavily
    • feeling faint
    • dizziness
    • tiredness
    • a weak but fast heart rate
    • lightheadedness caused by a drop in blood pressure when you stand up from a lying or sitting position (orthostatic hypotension)
    • muscle cramps
    • nausea
    • headache
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Trospium may cause dizziness and drowsiness. You shouldn’t drive, use machinery, or do other activities that require alertness until you know how trospium affects you.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

trospium May Interact with Other Medications

Oral tablet

Trospium can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Food interactions

Trospium should be taken at least one hour before meals or on an empty stomach. Taking it with food decreases how much of the drug gets absorbed by your body.

Alcohol interaction

Trospium can make you dizzy or drowsy. Drinking alcohol while taking trospium may make dizziness or drowsiness worse. You shouldn’t drink alcohol 2 hours before or after taking trospium extended-release capsules. In general, you should limit how much alcohol you drink while taking this medication.

Medications that might interact with this drug

Irregular heart rate medications

Taking these drugs together can increase their levels in your body. This puts you at a greater risk for side effects.

These drugs include:

  • procainamide

Anesthesia medications

Taking these drugs together can increase their levels in your body. This puts you at a greater risk for side effects.

These drugs include:

  • pancuronium

Pain medications

Taking these drugs together can increase their levels in your body. This puts you at a greater risk for side effects.

These drugs include:

  • morphine

Antibiotics

Taking these drugs together can increase their levels in your body. This puts you at a greater risk for side effects.

These drugs include:

  • vancomycin (Vancocin)

Antiviral medications

Taking these drugs together can increase their levels in your body. This puts you at a greater risk for side effects.

These drugs include:

  • tenofovir (Viread)

Diabetes medications

Taking these drugs together can increase their levels in your body. This puts you at a greater risk for side effects.

These drugs include:

  • metformin

Allergy medications

These drugs work in similar ways as trospium, and can have similar side effects. Taking these drugs together may increase the frequency and severity of side effects caused by trospium. These include dry mouth, constipation, trouble emptying your bladder, blurred vision, and drowsiness.

These drugs include:

  • diphenhydramine
  • hydroxyzine

Depression medications

These drugs work in similar ways as trospium, and can have similar side effects. Taking these drugs together may increase the frequency and severity of side effects caused by trospium. These include dry mouth, constipation, trouble emptying your bladder, blurred vision, and drowsiness.

These drugs include:

  • amitriptyline
  • desipramine
  • imipramine
  • nortriptyline

Overactive bladder drugs

These drugs work in similar ways as trospium, and can have similar side effects. Taking these drugs together may increase the frequency and severity of side effects caused by trospium. These include dry mouth, constipation, trouble emptying your bladder, blurred vision, and drowsiness.

These drugs include:

  • solifenacin
  • darifenacin
  • tolterodine

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Trospium warnings
urine flow problems
People with urine flow problems

You shouldn’t take trospium if you have problems urinating (urinary retention), bladder flow blockage (obstruction), or benign prostatic hyperplasia (BPH). Trospium may decrease your urine flow and make these conditions worse.

stomach problems
People with stomach problems

You shouldn’t take this drug if you have slowed or delayed emptying of your stomach (stomach or bowel blockage) or no movement in your intestines (gastric atony). Trospium can slow the movement of your stomach or intestines further and make these conditions worse.

glaucoma
People with uncontrolled narrow-angle glaucoma

You shouldn’t take trospium if you have uncontrolled narrow-angle glaucoma (increased eye pressure). This drug can make your condition worse.

kidney disease
People with kidney disease

Trospium is removed from your body by your kidneys. If your kidneys aren’t working well, more of the drug can stay in your body longer and put you at risk for side effects. If you have severe kidney disease, your doctor may decrease your dose of trospium immediate-release tablets. You shouldn’t use the extended-release capsules if you have severe kidney disease.

pregnant women
Pregnant women

Trospium is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Tell your doctor if you’re pregnant or plan to become pregnant. Trospium should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

breast-feeding
Women who are breast-feeding

It isn’t known if trospium passes into breast milk. If it does, it may cause serious effects in a child who is breast-fed.

You and your doctor may need to decide if you’ll take trospium or breast-feed.

seniors
For seniors

Seniors may be more likely to have the following side effects when taking this drug:

  • dry mouth
  • constipation
  • indigestion or stomach pain
  • urinary tract infection
  • urinary retention

If you have chronic constipation, your doctor may want you to avoid trospium because of the increased risk for constipation.

children
For children

This medicine hasn’t been studied in children and shouldn’t be used in children younger than 18 years.

call the doctor
When to call the doctor

Call your doctor if your symptoms of overactive bladder don’t improve or get worse.

allergies
Allergies

Trospium may cause serious allergic reaction. Symptoms include:

  • swelling of your face, lips, throat, mouth, or tongue
  • trouble breathing

Call 9-1-1 or go to the nearest emergency room if you develop these symptoms.

Don’t take this drug again if you’ve ever had an allergic reaction to it before. Taking it again could be fatal (cause death).

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How to Take trospium (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Overactive bladder (OAB)

Generic: trospium

Form: Oral immediate-release tablet
Strengths: 20 mg

Generic: trospium ER

Form: Oral extended-release tablet
Strengths: 60 mg
Adult dosage (ages 18–74 years)
  • immediate-release tablets: Take one 20-mg tablet by mouth two times per day. Take it with water on an empty stomach, at least one hour before eating a meal.
  • extended-release capsules: Take one 60-mg capsule by mouth one time per day in the morning. Take it with water on an empty stomach, at least one hour before eating a meal. You shouldn’t drink alcohol 2 hours before or after taking trospium extended-release capsules.
Child dosage (ages 0–17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children younger than 18 years.

Senior dosage (ages 75 years and older)
  • immediate-release tablets: To reduce your risk of side effects, your doctor may give you a lower dose. Your dose should be one 20-mg tablet taken by mouth one time per day. Take it with water on an empty stomach, at least one hour before a meal.
  • extended-release capsules: There are no specific recommendations for senior dosing. However, older adults may process this drug more slowly. A normal adult dose may cause levels of the drug to be higher than normal. If you’re a senior, your doctor may choose to switch you to a lower dose of trospium immediate-release tablets.
Special considerations

Kidney disease: Trospium is mostly removed from the body by your kidneys. If your kidneys aren’t working well, more of the drug can stay in your body longer and put you at risk for side effects. For those with severe kidney disease:

  • immediate-release tablets: Take one 20-mg tablet by mouth one time per day at bedtime.
  • extended-release capsules: People with severe kidney disease shouldn’t use this form.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Trospium comes with serious risks if you don’t take it as prescribed by your doctor.

If you miss a dose

If you forget to take your dose, take it as soon as you remember. If it’s just a few hours until the time of your next dose, then wait and only take one dose at that time.

Never try to catch up by taking two doses at once. This could cause toxic side effects.

If you don't take it at all or skip doses

If you don’t take trospium as prescribed by your doctor, you may still have symptoms of overactive bladder, including a strong need to urinate right away and having to go to the bathroom often.

If you take too much

Taking too much trospium may cause you to have these symptoms:

  • feelings of warmth and reddening of your face (flushing)
  • dangerously fast heart rate
  • inability to urinate
  • extreme sleepiness
  • severe confusion
  • hallucinations

If you think that you’ve take too much trospium, call your local poison control center or go to the emergency room right away.

How to tell if the drug is working

You can tell if darifenacin is working if your symptoms of overactive bladder improve. You may no longer have a strong need to urinate or a need to urinate more often.

Trospium is a long-term treatment.

Important considerations for taking trospium
do not take with food
Take trospium with water on an empty stomach, at least one hour before a meal
timing
Trospium extended-release capsule only: Take the capsule in the morning
can crush immediate-release
You may crush or cut the immediate-release tablet
do not crush extended-release
The extended-release form should be swallowed whole. Don’t open, crush, or chew these capsules
storage
Trospium must be stored at the right temperature
See Details
refillable
Prescription is refillable
travel
Travel
See Details
Clinical monitoring
Clinical monitoring
See Details
diet
Your diet
See Details
Insurance
Insurance
See Details

Trospium must be stored at the right temperature

  • Store trospium at room temperature between 68°F (20°C) and 77°F (25°C).
  • Keep this drug away from light.
  • Do not freeze trospium.
  • Keep it away from high temperature.
  • Keep your drugs away from areas where they could get wet, such as bathrooms. Store this drug away from moisture and damp locations.
  • Keep trospium and all drugs out of the reach of children.

Travel

When traveling with your medication:

  • Always carry your medication with you or in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt this medication.
  • You may need to show airport staff your pharmacy’s label to clearly identify the medication. Keep the original prescription label with you when traveling.
  • Don’t leave this medicine in the car, especially when the temperature is hot or freezing.

Clinical monitoring

Before starting trospium, your doctor will check your:

  • kidney function: These blood tests will help your doctor decide if trospium is safe for you to start and if you need a lower dose. If your kidney disease is severe, you shouldn’t take trospium extended-release capsules.   

Your diet

Trospium should be taken at least one hour before meals or on an empty stomach.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for trospium.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

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How Much Does trospium Cost?

Oral tablet

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Lowest price for trospium

Walmart $41.05
Walgreens $70.44
Rite-Aid $75.60
These prices represent the lowest priced national pharmacies for trospium on GoodRx. They may be lower than your insurance.

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These prices represent the lowest priced national pharmacies for trospium on GoodRx. They may be lower than your insurance.

Show Sources

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 8, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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