Trandolapril | Side Effects, Dosage, Uses & More
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Generic Name:

trandolapril, Oral tablet

All Brands

  • Mavik
SECTION 1 of 5

Highlights for trandolapril

Oral tablet
1

Trandolapril is an oral drug that’s used to treat hypertension (high blood pressure). It’s also used to increase your chance of survival after a heart attack. This drug may be taken alone or with other medications to treat your condition.

2

The standard starting dose for adults with high blood pressure who are not black is 1 mg per day, taken by mouth. The standard starting dose for adults with high blood pressure who are black is 2 mg. Your doctor may increase your dose up to a maximum of 8 mg per day. The starting dose for adults after myocardial infarction (heart attack) is 1 mg per day. The usual dose is 4 mg per day.

3

This drug may cause sudden swelling of your face, arms, legs, lips, tongue, throat, and intestines (angioedema). This can be fatal.

4

You shouldn’t take this drug if you’re pregnant or plan to become pregnant. Trandolapril can harm or be fatal to your unborn child.

5

Common side effects include low blood pressure, dizziness, a persistent cough, diarrhea, and fatigue.

IMPORTANT INFORMATION

FDA warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to effects that may be dangerous.

Use during pregnancy warning

You shouldn’t take this drug if you’re pregnant or plan to become pregnant. Trandolapril can harm or be fatal to your unborn child. If you become pregnant, stop taking this drug and call your doctor right away.

Swelling (angioedema)

This drug can cause sudden swelling of your face, arms, legs, lips, tongue, throat, and intestines. This can be fatal. Tell your doctor right away if you have swelling in these areas or stomach pain. Your doctor will tell you to stop taking the drug and you may be given medication to reduce the swelling. This can happen at any time while you’re taking trandolapril/verapamil. Your risk may be higher if you’ve had this problem with a medication similar to trandolapril (angiotensin-converting enzyme or ACE inhibitors).

Low blood pressure risk

Trandolapril can cause low blood pressure, especially in the first few days of starting treatment. Call your doctor if you feel lightheaded or faint. Your risk of low blood pressure may be higher if you:

  • aren’t drinking enough fluids
  • sweat heavily
  • have diarrhea or are vomiting
  • have heart failure
  • are on dialysis
  • take diuretics

Cough

Trandolapril may cause a persistent, dry, non-productive cough. This cough will go away once you stop taking the medication.

What is trandolapril?

Trandolapril is a prescription drug. It’s available as an oral tablet.

Trandolapril is available as a generic drug. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand. Talk to your healthcare provider to see if the generic will work for you.

Trandolapril may be taken as part of a combination therapy with other drugs.

Why it's used

Trandolapril is used to treat high blood pressure. It’s also used to treat heart failure, including left ventricular dysfunction after a heart attack.

How it works

Trandolapril belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors. A class of drugs is a group of medications that work in a similar way. They are often used to treat similar conditions.

More Details

How it works

Trandolapril belongs to a class of drugs called angiotensin-converting enzyme (ACE) inhibitors. A class of drugs is a group of medications that work in a similar way. They are often used to treat similar conditions.

Trandolapril relaxes the blood vessels in your body. This lowers your blood pressure and also helps reduce the stress on your heart.

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SECTION 2 of 5

trandolapril Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with trandolapril include:

  • persistent cough

  • dizziness

  • headache

  • fatigue

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have any of these serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency.

  • Swelling (angioedema). Symptoms include:

    • swelling of the face, lips, tongue, throat
    • trouble breathing
    • trouble swallowing
  • Low blood pressure. Symptoms include:

    • lightheadedness
  • Liver failure. Symptoms include:

    • yellowing of your skin or the whites of eyes
    • abdominal pain
    • fatigue
  • Low white blood cells. Symptoms include:

    • flu-like symptoms, including fever and chills
  • High potassium levels. Symptoms include:

    • weakness
    • nausea
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy
Trandolapril does not cause drowsiness.
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

trandolapril May Interact with Other Medications

Oral tablet

Trandolapril can interact with other medications, herbs, or vitamins you might be taking. An interaction is when a substance changes the way a drug works. This can be harmful or cause the drugs that you take to not work as well. To help prevent interactions, your doctor should manage all of your medications carefully. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Medications that might interact with this drug

Cancer and organ transplant drugs

Taking these drugs with trandolapril may increase your risk of angioedema (swelling under the surface of your skin).

These drugs include:

  • temsirolimus
  • sirolimus
  • everolimus

Blood pressure medications

These drugs may increase your risk for low blood pressure, high blood potassium, and kidney problems when taken with trandolapril.

These drugs include:

  • angiotensin receptor blockers (ARBs), such as:
    • candesartan
    • eprosartan
    • irbesartan
    • losartan
    • olmesartan
    • telmisartan
    • valsartan
    • azilsartan
  • angiotensin-converting enzyme (ACE) inhibitors, such as:
    • benazepril
    • captopril
    • enalapril
    • fosinopril
    • lisinopril
    • moexipril
    • perindopril
    • quinapril
    • ramipril
  • direct renin inhibitors, such as:
    • aliskiren

Diuretics (water pills)

Taking these drugs with trandolapril can make your blood pressure too low. These drugs include

  • hydrochlorothiazide
  • chlorthalidone
  • furosemide
  • bumetanide

Potassium supplements

These medications can increase the potassium in your body.

Potassium sparing diuretics

These medications can increase the potassium in your body.

These drugs include:

  • spironolactone
  • amiloride
  • triamterene

Pain medications

These medications can decrease your kidney function when taken with trandolapril. These drugs include:

  • non-steroidal anti-inflammatory drugs (NSAIDs), such as:
    • naproxen
    • ibuprofen
    • diclofenac
    • sulindac
    • indomethacin
    • ketoprofen
    • flurbiprofen

Injectable gold

Using injectable gold with trandolapril may increase your risk of nitritoid reactions. Symptoms include:

  • reddening and warming of your face (flushing)
  • nausea
  • vomiting
  • low blood pressure

Mood stabilizers

Trandolapril can increase the effects of these medications:

  • lithium

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Trandolapril warnings
People with kidney problems
People with kidney problems

Trandolapril can worsen your kidney function or even cause new kidney problems. Your doctor may need to reduce your dose, or you may need to stop using this drug. Your doctor may do blood tests to see how the drug is affecting your kidneys. You may also be more sensitive to fosinopril if you have a history of kidney problems.

If you have kidney problems, you are also at increased risk of high blood potassium levels. Potassium is a mineral that helps your nerves, muscles, and organs work normally. Very high levels of potassium can cause heart rhythm problems that can be life-threatening.

People with diabetes
People with diabetes

This drug may affect your blood sugar levels. Your doctor may adjust your diabetes medications while you’re taking trandolapril. Your doctor will tell you how often to test your blood sugar. If you have diabetes, you also have a high risk of developing high potassium levels while taking this drug.

People with systemic lupus erythematosus
People with systemic lupus erythematosus

Trandolapril can cause your white blood cell counts to decrease. This raises your risk of infection. This is more likely to occur if you have lupus. If you have lupus and take this drug, tell your doctor any time you have a fever or sore throat.

People with scleroderma
People with scleroderma

Trandolapril can cause your white blood cell counts to decrease. This raises your risk of infection. This is more likely to occur if you have scleroderma. If you have scleroderma and take this drug, tell your doctor any time you have a fever or sore throat.

Pregnant women
Pregnant women

Trandolapril is a category D pregnancy drug. That means two things:

  1. Studies show a risk of adverse effects to the fetus when the mother takes the drug.
  2. The benefits of taking the drug during pregnancy may outweigh the potential risks in certain cases.

This drug can harm or be fatal to your unborn baby.

Tell your doctor if you’re pregnant or plan to become pregnant. Trandolapril should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

Women who are breast-feeding
Women who are breast-feeding

Trandolapril may pass into breast milk and cause serious effects in a breast-feeding child.

You and your doctor may need to decide if you’ll take this drug or breast-feed.

For seniors
For seniors

Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal in your body. If you’re a senior, you may need a lower dose or a different schedule.

For children
For children

This medicine hasn’t been studied in children and shouldn’t be used in children younger than 18 years.

Allergies
Allergies

Trandolapril can cause a severe allergic reaction. Symptoms include:

  • trouble breathing
  • swelling of your throat or tongue
  • hives

Don’t take this drug again if you’ve ever had an allergic reaction to it before. Taking it a second time after an allergic reaction could be fatal.

SECTION 4 of 5

How to Take trandolapril (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your doctor will tell you what dosage is right for you. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Hypertension

Brand: Mavik

Form: Oral tablet
Strengths: 1 mg, 2mg, 4 mg

Generic: trandolapril

Form: Oral tablet
Strengths: 1 mg, 2mg, 4 mg
Adult dosage (ages 18–64 years):
  • starting dose:
    • people who aren’t black: 1 mg taken by mouth once daily
    • people who are black: 2 mg taken by mouth once daily
  • usual dose: 2–4 mg taken once daily
  • maximum dose: 8 mg, taken once per day, or 4 mg, taken two times per day
Child dosage (ages 0–17 years):

This medicine hasn’t been studied in children and shouldn’t be used in children younger than 18 years.

Senior dosage (ages 65 years and older):

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal. If you’re a senior, you may need a lower dose or a different schedule.

Special considerations

Kidney problems: Trandolapril is removed from your body by your kidneys. Your doctor should start you on a lower dose if you have kidney problems.

Liver problems: Trandolapril is removed from your body by your liver. Your doctor should start you on a lower dose if you have liver problems.

People who take water pills You’ll start on 0.5 mg taken once per day if you also take a water pill (diuretic). Your blood pressure should be monitored closely to make sure your blood pressure level does not drop too low

Heart failure after myocardial infarction

Brand: Mavik

Form: Oral tablet
Strengths: 1 mg, 2mg, 4 mg

Generic: trandolapril

Form: Oral tablet
Strengths: 1 mg, 2mg, 4 mg
Adult dosage (ages 18–64 years):
  • starting dose: 1 mg taken by mouth once per day
  • usual dose: 4 mg taken by mouth once per day
Child dosage (ages 0–17 years):

This medicine hasn’t been studied in children and shouldn’t be used in children younger than 18 years.

Senior dosage (ages 65 years and older):

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of this drug to be higher than normal. If you’re a senior, you may need a lower dose or a different schedule.

Special considerations

Kidney problems: Trandolapril is removed from your body by your kidneys. Your doctor should start you on a lower dose if you have kidney problems.

Liver problems: Trandolapril is removed from your body by your liver. Your doctor should start you on a lower dose if you have liver problems.

People who take water pills You’ll start on 0.5 mg taken once per day if you also take a water pill (diuretic). Your blood pressure should be monitored closely to make sure your blood pressure level does not drop too low

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Trandolapril comes with serious risks if you don't take it as prescribed.

If you don't take it at all

Your blood pressure will stay high. This will raise your risk for a heart attack and stroke.

If you stop taking it suddenly

If you stop taking this drug suddenly, your blood pressure may spike. This can cause anxiety, sweating, and a fast heart rate.

If you don't take it on schedule

You may not feel any different, but your blood pressure may not be controlled. This can put you at higher risk for a heart attack and stroke.

What to do if you miss a dose

If you forget to take your dose, take it as soon as you remember. If it’s just a few hours before the time for your next dose, then wait and only take one dose at that time. Never try to catch up by taking two doses at once. This could cause toxic side effects.

If you take too much

If you take too much trandolapril, your blood pressure could drop to levels that are too low. Symptoms of blood pressure levels that are too low include dizziness and fainting. Call your doctor or poison control center, or go to the emergency room if you think you have taken too much of this drug.

How to tell this drug is working

You may not be able to tell whether this drug is working or not. It’s important that you take your medicine every day as directed. Your doctor will check your blood pressure regularly and decide if this drug is working for you.

Trandolapril is used for long-term treatment.

Important considerations for taking trandolapril
You should take Trandolapril at the same time every day.
You should take trandolapril at the same time every day
You can crush and cut the tablet.
You can crush and cut the tablet
Storage
Store trandolapril at room temperature between 68°F (20°C) and 77°F (25°C)
Refillable
Prescription is refillable
Travel
Travel
See Details
Self-management
Self-management
See Details
Clinical monitoring
Clinical monitoring
See Details
Hidden costs
Hidden costs
See Details

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt this medication.
  • You may need to show airport security staff the pharmacy prescription label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medicine in your glove compartment or leave it in the car, especially when the temperature is hot or freezing.

Self-management

You may need to check your blood pressure at home. You may need to buy a home blood pressure monitor to do this. You should keep a log with the date, time of day, and your blood pressure readings. Bring this diary with you to your doctor appointments.

Clinical monitoring

Your doctor will do the following tests during treatment with trandolapril to decide your dose and check if this drug is working for you:

  • blood pressure
  • liver function
  • kidney function
  • blood potassium

Hidden costs

You may need to purchase a blood pressure monitor to check your blood pressure at home. These are available at most pharmacies.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other options that may work for you.

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How Much Does trandolapril Cost?

Oral tablet

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Lowest price for trandolapril

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Kroger Pharmacy $13.91
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These prices represent the lowest priced national pharmacies for trandolapril on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on March 24, 2016

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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