Highlights for tolvaptan
tolvaptan Side Effects
Side effects that you should report to your doctor or health care professional as soon as possible:\n-allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue\n-black or tarry stools\n-chest pain\n-confusion\n-fast, irregular heartbeat\n-mood changes\n-seizures\n-trouble speaking\n-uncontrollable body movements\n-unusually weak or tired\n-vomiting blood\n \nSide effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):\n-constipation\n-dry mouth\n-increased hunger or thirst\n-increased urination
tolvaptan May Interact with Other Medications
Do not take this medicine with any of the following medications:\n-clarithromycin\n-delavirdine\n-dalfopristin; quinupristin\n-indinavir\n-isoniazid\n-itraconazole\n-ketoconazole\n-nefazodone\n-nelfinavir\n-ritonavir\n-saquinavir\n-telithromycin\n-tipranavir\n \nThis medicine may also interact with the following medications:\n-aprepitant\n-cyclosporine\n-digoxin\n-diuretics\n-erythromycin\n-grapefruit juice\n-medicines for blood pressure\n-medicines for seizures like carbamazepine, phenobarbital, phenytoin\n-medicines for tuberculosis like rifampin, rifabutin, and rifapentine\n-some medicines for fungal infections like fluconazole, miconazole, voriconazole\n-St. John's Wort
How to Use tolvaptan
Take this medicine by mouth with a glass of water. This medicine will be started in a hospital. You may need to continue this medicine at home. Follow the directions on the prescription label. Do not stop and re-start this medicine on your own. You may need to go back to a hospital to re-start this medicine. You can take it with or without food. If it upsets your stomach, take it with food. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on your doctor's advice.\n \nA special MedGuide will be given to you by the pharmacist with each prescription and refill. Be sure to read this information carefully each time.\n \nTalk to your pediatrician regarding the use of this medicine in children. Special care may be needed.
They need to know if you have any of these conditions:\n-can not feel if you are thirsty\n-diarrhea or vomiting\n-if you frequently drink alcohol containing drinks\n-kidney disease and your body can not make urine\n-liver disease\n-not eaten enough for a long period of time (malnourished)\n-an unusual or allergic reaction to tolvaptan, other medicines, foods, dyes, or preservatives\n-pregnant or trying to get pregnant\n-breast-feeding
If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.
Your condition will be monitored carefully while you are receiving this medicine.\n \nTo prevent dehydration, have water available to drink at all times while taking this medicine. Drink when you are thirsty, unless your doctor or healthcare professional tells you otherwise.\n \nYou may get drowsy or dizzy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.
Keep out of the reach of children.\n \nStore at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Throw away any unused medicine after the expiration date.
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Last Updated: September 14, 2009