Highlights for sodium-hyaluronate
Hyaluronate is an injected treatment used to treat knee pain due to osteoarthritis. It’s given by your healthcare provider.
Common side effects include pain and stiffness in the knee, injection site reactions, back pain, headache, and upset stomach.
Avoid strenuous or prolonged physical activity for 48 hours after your hyaluronate injection. Don’t jog, play sports, lift heavy objects, or stand for more than an hour at a time.
What is hyaluronate?
This drug is a prescription medication that’s injected in your knee. It’s only give by a healthcare provider in a clinical setting.
Why it's used
This drug is used to relieve knee pain due to osteoarthritis. It’s used in people who don’t get enough relief from over-the-counter pain medicines or from exercise and physical therapy.
How it works
Hyaluronate is a gel-like, elastic substance found in your joints that is needed for them to work properly.
sodium-hyaluronate Side Effects
Most Common Side Effects
The most common side effects that occur with hyaluronate include:
pain and stiffness in your knee or at the injection site
swelling, redness, or warmth in or around your knee
bruising or redness at the injection site
Serious Side Effects
If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.
allergic reaction. Symptoms may include:
- red, swollen skin
- tightness in your chest
- trouble breathing
- swelling of your face, lips, tongue, or throat
- sudden drop in blood pressure. Symptoms may include dizziness, feeling faint, and trouble breathing.
knee joint infection. Symptoms may include:
- being unable to move your knee
- severe pain in your knee, especially when you try to move it
- knee swelling
- knee redness
This drug does not cause drowsiness.
Mild side effects may disappear within a few days or a couple of weeks. Talk to your doctor or pharmacist if they’re more severe or don’t go away.
sodium-hyaluronate May Interact with Other Medications
Hyaluronate can interact with other medications, herbs, or vitamins you might be taking. Your healthcare provider will look out for interactions with your current medications. Always be sure to tell your doctor about all medications, herbs or vitamins you’re taking.
How to Take sodium-hyaluronate (Dosage)
Your doctor will determine a dose that’s right for you based on your individual needs. Your general health may affect your dose. Tell your doctor about all health conditions you have before your doctor or nurse administers the drug to you.
This drug comes with risks if you don’t take it as prescribed by your doctor.
If you stop or miss doses
If you don’t receive your injections or don’t receive it when you’re supposed to, you may still experience pain in your knee.
What to do if you miss a dose/appointment
If you miss an appointment, call your doctor right away to reschedule it.
How to tell the drug is working
You may be able to tell the drug is working if you experience less knee pain and are able to move around better.
This is a short-term treatment.
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- Orthovisc- high molecular weight hyaluronan (n.d.). Retrieved from http://www.accessdata.fda.gov/cdrh_docs/pdf3/p030019c.pdf
- Supartz – sodium hyaluronate. (2012, June). Retrieved from http://supartzprofessional.com/docs/PackageInsert.pdf
Content developed in collaboration with University of Illinois-Chicago, Drug Information Group
Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on June 1, 2015