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Generic Name:

rilpivirine, Oral tablet

All Brands

  • EDURANT
SECTION 1 of 5

Highlights for rilpivirine

Oral tablet
1

Rilpivirine should only be given to people who have less than 100,000 copies of the human immunodeficiency virus (HIV) per milliliter of blood at the start of treatment. Others may not have good results with this drug.

2

This drug has many drug interactions. Some of the interactions can be managed with dose adjustments. Tell your doctor and pharmacist about all the drugs you’re taking.

3

In general, the rilpivirine dose is taken once per day with food. It’s only available as a 25-mg tablet.

4

Rilpivirine has caused depression in some people. If you experience serious depression after starting this drug, see your doctor immediately.

5

Always take this drug as prescribed. For rilpivirine to be most effective, you need to take it every day in combination with other HIV drugs.

IMPORTANT INFORMATION

May cause severe depression

Severe depression is a serious side effect. If you’re taking this drug and become very depressed, see a doctor right away.

Liver disease warning

Some people may develop liver disease while taking rilpivirine. Your doctor may check your liver function periodically while you take this drug. In addition, if you have hepatitis B or C virus, you could have worsening liver function while taking this drug. Your doctor should monitor your liver function while you take it.

Immune reconstitution syndrome

Your recovering immune system may cause infections you’ve had treated in the past to return. Examples of past infections include fungal infections, pneumonia, or tuberculosis. Your doctor may need to re-treat these old infections if this happens.

What is rilpivirine?

Rilpivirine is a prescription drug. It’s available as an oral tablet.

Rilpivirine is used as part of a combination therapy. That means you’ll need to take it in combination with other drugs.

Why it's used

Rilpivirine is used in combination with other antiretroviral drugs to treat HIV infection. It doesn’t cure HIV infection, but it may help to control it.

More Details

How it works

Rilpivirine is a non-nucleoside reverse transcriptase inhibitor (NNRTI). It works by attaching to the HIV virus and blocking the virus from making copies of itself. This slows the virus’s progression.

Why It's Used

Rilpivirine is used in combination with other antiretroviral drugs to treat HIV infection. It doesn’t cure HIV infection, but it may help to control it.

It’s approved for adults who haven’t been previously treated for HIV infection and have 100,000 copies per milliliter or less of the virus at the start of treatment.

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SECTION 2 of 5

rilpivirine Side Effects

Oral tablet

More common side effects

Some of the most common side effects that occur with rilpivirine include:

  • changes in body fat, including increased fat on the back of your neck

  • insomnia

  • depression or depressed mood

  • headache or migraine

  • fatigue or malaise

  • dizziness or vertigo

  • nausea

  • diarrhea

  • rash

  • fever

  • abdominal pain

  • increased cholesterol level

Serious side effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • severe depression.

  • immune reconstitution syndrome. In this condition, your recovering immune system causes infections you’ve had in the past to return. Examples of past infections include fungal infections, pneumonia, or tuberculosis. Watch for returning symptoms of your past infections.

  • worsening liver function. Symptoms may include:

    • dark urine
    • loss of appetite
    • fatigue
    • yellowing of your skin or whites of your eyes
    • nausea
    • tenderness in your stomach area
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Rilpivirine does not cause drowsiness.

Most common side effects will disappear within a few weeks. See your doctor if they don’t go away or become bothersome.

If you’re taking other drugs with rilpivirine and start to feel tired or dizzy, or your heart seems to be beating more slowly, see your doctor right away. If this effect is severe, call 9-1-1 or get to an emergency room.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

rilpivirine May Interact with Other Medications

Oral tablet

Rilpivirine interacts with many other medications. It can also interact with herbs or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Some of these drugs interact with rilpivirine, but you may still be able to take them together. If you start taking a new drug with rilpivirine and feel tired or your heart seems to be beating more slowly, call your doctor or pharmacist. Your doctor may change the dose of one of the drugs or may change you to another drug.

Medications That May Interact with This Drug

Antacids
  • aluminum/magnesium hydroxide
  • calcium carbonate

If you take an antacid, take it at least 2 hours before or 4 hours after your dose of rilpivirine. Antacids can decrease the amount of rilpivirine your body absorbs, which may cause it not to work.

Acid-reducing drugs

Acid-reducing drugs are also called H2 blockers or proton-pump inhibitors.

They include:

  • cimetidine (Tagamet)
  • esomeprazole (Nexium)
  • famotidine (Pepcid)
  • lansoprazole (Prevacid)
  • nizatidine (Axid)
  • omeprazole (Prilosec, Zegerid)
  • pantoprazole (Protonix)
  • rabeprazole (AcipHex)
  • ranitidine (Zantac)

Don’t take proton-pump inhibitors with rilpivirine. If you take an H2 blocker, take it 12 hours before or at least 4 hours after rilpivirine. Acid-reducing drugs can decrease the amount of rilpivirine your body absorbs, which may cause it not to work.

Antibiotics

Some antibiotics can increase the levels of rilpivirine in your body, which can cause more side effects. Others can decrease the levels of rilpivirine in your body, which may cause it not to work.

These include:

  • clarithromycin (Biaxin)
  • erythromycin (Ery-Tab, PCE, Eryc)
  • rifabutin  (Rifamate, Rifadin)
  • telithromycin (Ketek)

Antifungals

Some antifungals can increase the levels of rilpivirine in your body, potentially resulting in more side effects.

These include:

  • fluconazole (Diflucan)
  • itraconazole (Sporonox)
  • ketoconazole (Nizoral)
  • posaconazole (Noxafil)
  • voriconazole (Vfend)

Epilepsy drugs

Some epilepsy drugs can decrease the levels of rilpivirine in your body, which may cause it not to work. Don’t take rilpivirine with:

  • carbamazepine (Tegretol, Carbatrol)
  • oxcarbazepine (Trileptal)
  • phenobarbital (Luminal)
  • phenytoin (Dilantin)

Herbal drug
  • St. John’s wort (Hypericum perforatum)

This herbal supplement can decrease the levels of rilpivirine in your body. Don’t take St. John’s wort with rilpivirine.

Human immunodeficiency virus (HIV) drugs

Some HIV drugs can increase the levels of rilpivirine in your body, which can cause more side effects.

These include:

  • atazanavir (Reyataz)
  • efavirenz (Sustiva)
  • etravirine (Intelence)
  • fosamprenavir (Lexiva)
  • nelfinavir (Viracept)
  • tipranavir (Aptivus)

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Rilpivirine warnings
liver
People with hepatitis B or C virus infection

If you have hepatitis B or C virus infection, you could have worsening liver function while taking this drug. Your doctor should monitor your liver function while you take rilpivirine. Symptoms of worsening liver function may include:

  • dark urine 
  • loss of appetite
  • fatigue
  • yellowing skin or whites of your eyes
  • nausea
  • tenderness in your stomach area. 
kidney disease
People with kidney disease

If you have kidney disease, your kidneys may not filter the drug from your system as well as they should. The drug could build up in your body and cause toxic effects.

brain
People with depression

If you have depression or have previously been treated for depression, talk to your doctor before taking rilpivirine. Some people experience severe depression while taking this drug.

pregnant women
Pregnant women

Rilpivirine is a pregnancy category B drug. That means two things:

  1. Studies of the drug in pregnant animals have not shown risk to the fetus.
  2. There aren’t enough studies done in pregnant women to show if the drug poses a risk to the fetus.

This drug should only be used during pregnancy if the possible benefit outweighs the possible risks to the fetus. Talk to your doctor about this drug if you’re pregnant or plan on becoming pregnant.

breastfeeding
Women who are nursing

The Centers for Disease Control and Prevention recommend that women with HIV infection not breastfeed in order to avoid passing HIV to their babies.

Additionally, studies of rilpivirine in animals show that it passes through breast milk.

seniors
For Seniors

If you’re older than 65 years, this drug may be processed and removed more slowly from your body. Your doctor may start you on a lowered dose to prevent build up of the drug, which could be harmful.

children
For Children

This drug hasn’t been approved for use in people younger than 18 years.

telephone
When to call the doctor

Call your doctor if you think you’re experiencing symptoms, such as unexplainable:

  • fever
  • weakness
  • chills
  • night sweats
  • sore throat
  • joint pain

This may be a sign the drug isn’t working, and you may need a different treatment.

SECTION 4 of 5

How to Take rilpivirine (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Human immunodeficiency virus (HIV) infection

Brand: Edurant

Form: Oral Tablet
Strength: 27.5 mg rilpivirine hydrochloride (Contains 25 mg rilpivirine)
Adult Dosage (ages 18-64 years)

The dose is one 25-mg tablet taken once per day with a meal.

Child Dosage (ages 0-17 years)

This medicine hasn’t been studied in children and shouldn’t be used in children under the age of 18 years.

Senior Dosage (ages 65 years and older)

There are no specific recommendations for senior dosing. Older adults may process drugs more slowly. A normal adult dose may cause levels of the drug to be higher than normal. If you’re a senior, you may need a lower dose or you may need a different schedule.

Special considerations

Liver Disease: Depending on how severe your liver disease is, your doctor may put you on a lowered dose or may recommend that you don’t take this drug at all. This drug is processed in your liver. If you have impaired liver function from disease, too much of the drug may build up in your body and cause harmful effects.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Keeping HIV infection under control requires lifelong treatment. There can be serious health consequences if you don’t take this drug exactly how your doctor tells you.

If You Don’t Take It at All

If you don’t take it at all, your HIV infection will eventually reduce your immunity to a point that your body won’t be able to defend itself against many types of infections. You may not be able to defend yourself against infections that are commonly cured in people who don’t have HIV infection.

If You Stop or Miss Doses

If you stop taking this medication, miss doses, or don’t take it on schedule, the amount of medication in your body fluctuates. This can allow the HIV in your body to become resistant to the drug, which means the drug stops working.

If You Don’t Take It on Schedule

Taking your drug at the same time every day keeps a constant amount of the drug in your body. This helps make the drug as effective as possible at keeping the virus under control. If you don’t take it on schedule, the drug may not be as effective.

What To Do if I Miss a Dose

If you’re just a few hours late for your daily dose, take it as soon as you remember.

If it's just a few hours until your next dose, wait and take a single dose at the usual time.

Take just one dose at a time. Never try to catch up by taking a double dose. This could result in toxic side effects.

How Can I Tell if the Drug Is Working?

To see how well your treatment is working, your doctor will check your:

  • virus count. A virus count measures the number of copies of the HIV virus in your body.
  • CD4 count. A CD4 count measures the amount of CD4 cells in your body. CD4 cells are white blood cells that fight infection. An increased CD4 cell count is a sign that your HIV treatment is working.

Rilpivirine is a long-term drug treatment.

Important considerations for taking this drug

Store at room temperature: 68–77°F (20–25°C)

You can keep it for a short amount of time in temperatures as low as 59°F (15°C) and as high as 86°F (30°C). Keep rilpivirine tightly closed in its original bottle. Protect it from light.

Note: Be careful of moist environments, including bathrooms. To keep drugs away from moisture, store them somewhere other than your bathroom and any other damp location.

Clinical Monitoring

Before and during your rilpivirine treatment, your doctor may check your:

  • liver function
  • cholesterol
  • virus count. A virus count measures the number of copies of the HIV virus in your blood.
  • CD4 count. A CD4 count measures the amount of CD4 cells in your body. CD4 cells are white blood cells that fight infection. An increased CD4 count is a sign that your HIV treatment is working.

Not every pharmacy stocks this drug, so call ahead

If you only need a few tablets, you should call and ask if your pharmacy dispenses only a small number of tablets. Some pharmacies can't dispense only part of a bottle.

This drug is often available from specialty pharmacies through your insurance plan. These pharmacies operate like mail order pharmacies and ship the drug to you.

In larger cities, there will often be HIV pharmacies where you can have your prescriptions filled. Ask your doctor if there's an HIV pharmacy in your area.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for rilpivirine.

Are There Any Alternatives?

There are other drugs and combinations that can treat HIV infection. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

SECTION 5 of 5

How Much Does rilpivirine Cost?

Oral tablet

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Lowest price for rilpivirine

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These prices represent the lowest priced national pharmacies for rilpivirine on GoodRx. They may be lower than your insurance.

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Content developed in collaboration with Susan J. Bliss, RPh, MBA

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on April 20, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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