Generic Name: rifapentine, Oral tablet

Priftin

All Brands

  • Priftin
SECTION 1 of 4

Highlights for rifapentine

Oral tablet
1
RIFAPENTINE (RIF a pen teen) is an antibiotic. It is used to treat of tuberculosis (TB). This medicine is never used alone for tuberculosis, but in combination with at least one other agent.
2 3 4
Talk to your healthcare provider if you have any of these conditions.
5
Know what to watch for and get tips for reducing your risks while taking this drug.
SECTION 2 of 4

rifapentine Side Effects

Oral tablet

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • dark urine
  • felling faint, dizzy
  • fever
  • loss of appetite
  • pain or swelling of the joints
  • pinpoint red spots on the skin
  • trouble passing urine or change in the amount of urine
  • unusual bleeding, bruising
  • unusually weak or tired
  • yellowing of the eyes or skin

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • diarrhea
  • headache
  • nausea, vomiting
  • stomach pain
SECTION 3 of 4

rifapentine May Interact with Other Medications

Oral tablet

Do not take this medicine with any of the following medications:

  • medicines for HIV
  • voriconazole

This medicine may also interact with the following medications:

  • antifungal medicines like fluconazole, itraconazole, ketoconazole
  • barbituates, like phenobarbital
  • birth control pills
  • clofibrate
  • cyclosporine
  • levothyroxine
  • medicines that treat or prevent blood clots like warfarin
  • medicines for depression, anxiety, or psychotic disturbances
  • medicines for sleep
  • oral medicines for diabetes
  • quinine
  • sildenafil
  • some antibiotics like chloramphenicol, clarithromycin, dapsone, doxycycline, ciprofloxacin
  • some medicines for heart rhythm problems like disopyramide, mexiletine, quinidine, tocainide
  • some heart medicines like digoxin, diltiazem, nifedipine, verapamil
  • some medicines for seizures like phenytoin
  • some prescription pain medications like methadone
  • steroid medicines like prednisone or cortisone
  • tacrolimus
  • theophylline
SECTION 4 of 4

How to Use rifapentine

Oral tablet

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take this medicine with food. Take your medicine at regular intervals. Do not take your medicine more often than directed. For your therapy to work as well as possible, take each dose exactly as prescribed. Do not skip doses or stop your medicine even if you feel better. Skipping doses may make the TB resistant to this medicine and other medicines. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 2 years old for selected conditions, precautions do apply.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • immune system problems
  • liver disease
  • an unusual or allergic reaction to rifapentine, rifabutin, rifampin, other medicines, foods, dyes or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. You will need to have blood work done regularly while you are taking this medicine. This medicine can cause serious liver problems. Make sure you understand the risks for liver problems and how to identify the symptoms. If you have any questions, talk with your doctor or other health care provider.

Avoid alcoholic drinks while you are taking this medicine. Drinking alcohol during treatment with this medicine increases the risk of serious liver problems.

Do not treat diarrhea with over the counter products. Contact your doctor if you have diarrhea that lasts more than 2 days or if it is severe and watery.

You may need to take a vitamin B6 supplement while you are taking this medicine. Discuss the foods you eat and the vitamins you take with your health care professional.

Birth control pills may not work properly while you are taking this medicine. Talk to your doctor about using an extra method of birth control.

Antacids may reduce the absorption of this medicine. Doses of this medicine should be given at least 1 hour before taking antacids.

This medicine can color your urine, feces (stool), perspiration (sweat), tears, sputum, skin or saliva reddish-orange to reddish-brown. This color can last for as long as you take this medicine and is not a cause for alarm. This color in tears may permanently stain soft contact lenses. It is better not to wear soft contact lenses while you are taking this medicine. This medicine may stain dentures.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from heat and moisture. Throw away any unused medicine after the expiration date.

Thank you.

Your message has been sent.

We're sorry, an error occurred.

We are unable to collect your feedback at this time. However, your feedback is important to us. Please try again later.

Last Updated: January 2, 2014

The Healthline Site, its content, such as text, graphics, images, search results, and other material contained on the Healthline Site ("Content"), its services, and any information or material posted on the Healthline Site by third parties are provided for informational purposes only. None of the foregoing is a substitute for professional medical advice, examination, diagnosis, or treatment. Always seek the advice of a physician or other qualified healthcare provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on the Healthline Site. If you think you may have a medical emergency, call your doctor or 911 immediately. Please read the Terms of Service for more information regarding use of the Healthline Site.
Content licensed by
Gold Standard Logo

Healthline - Gold Standard License

Terms of Use

Licensee provides access to Alchemy provided by Gold Standard, Inc. ("Gold Standard"). Although Gold Standard makes reasonable efforts to ensure the accuracy and reliability of Alchemy, End User acknowledges and agrees that Licensee, its affiliates, and their respective officers, directors, employees and information providers and Gold Standard, its affiliates, its licensors, and their respective officers, directors, employees and information providers will not be held liable for any damages suffered or incurred by End User or any third person arising out of: a) any faults, interruptions or delays in Alchemy or its delivery, b) any use of or reliance on Alchemy by any person, or c) any inaccuracies, errors or omissions in Alchemy, irrespective of however such faults, interruptions, delays, inaccuracies, errors or omissions arise. Gold Standard shall not be liable to End User for any loss, cost or damages resulting from any delays in delivery and/or non-delivery of Alchemy or its content. End User acknowledges and agrees that its sole and exclusive remedy in the event of such delay is to not accept these terms and conditions. Gold Standard does not represent or warrant that Alchemy will meet the objectives or needs of End User or any third party. Gold Standard makes no warranty of merchantability of Alchemy or of the fitness of Alchemy for any purpose.

About Gold Standard

The Gold Standard editorial staff develops clinically-based drug information content through an independent, peer-reviewed process. Content updates to the database include new FDA-approved drugs, new non-prescription and herbal therapies, newly published information regarding FDA label changes and relevant clinical studies affecting off-label utilization. Editors do not have any significant financial relationships with the industry that would introduce bias in the editing or review of database content.

Read this Next

The Best Multiple Sclerosis iPhone and Android Apps of the Year
The Best Multiple Sclerosis iPhone and Android Apps of the Year
These best multiple sclerosis apps provide helpful information and tools to keep track of your symptoms, including medication reminders.
Timeline of an Anaphylactic Reaction
Timeline of an Anaphylactic Reaction
From first exposure to life-threatening complications, learn how quickly an allergy attack can escalate and why it can become life threatening.
Numbness, Muscle Pain and Other RA Symptoms
Numbness, Muscle Pain and Other RA Symptoms
The symptoms of RA are more than just joint pain and stiffness. Common symptoms include loss of feeling, muscle pain, and more. Learn more in this slideshow.
Advertisement
Advertisement
Advertisement