Generic Name: probenecid, Oral tablet

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Highlights for probenecid

Oral tablet
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PROBENECID (proe BEN e sid) helps to remove excess uric acid from the body. This medicine is used to prevent gouty attacks. It is also used to increase the amount of time that some antibiotics stay in the body.
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Talk to your healthcare provider if you have any of these conditions.
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Know what to watch for and get tips for reducing your risks while taking this drug.
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probenecid Side Effects

Oral tablet

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips, or tongue
  • blood in urine
  • breathing difficulty
  • fever, chills, infection
  • lower back or side pain
  • pain, difficulty passing urine
  • painful, swollen joints
  • unusual bleeding or bruising
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • dizzy
  • flushing
  • frequent passing of urine
  • hair loss
  • headache
  • loss of appetite
  • nausea, vomiting
  • sore gums
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probenecid May Interact with Other Medications

Oral tablet

Do not take this medicine with any of the following medications:

  • aspirin and aspirin-like medicines
  • ketorolac
  • methotrexate
  • topiramate

This medicine may also interact with the following medications:

  • acetaminophen
  • alcohol
  • antibiotics including penicillins, sulfonamides
  • antiviral medicines such as acyclovir, famciclovir, ganciclovir
  • certain medicines for gout like pegloticase
  • lorazepam
  • meclofenamate
  • medicines for diabetes
  • medicines for sleep during surgery
  • NSAIDs, medicines for pain and inflammation, like ibuprofen or naproxen
  • pyrazinamide
  • rifampin
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
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How to Use probenecid

Oral tablet

Take this medicine by mouth with a full glass of water. Follow the directions on the prescription label. Take your medicine at regular intervals. Do not take your medicine more often than directed. Do not stop taking except on your doctor's advice.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed. Do not use this medicine in children under 2 years old.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • acute gouty attack
  • blood disorders or disease
  • kidney disease, or kidney stones
  • recent radiation therapy
  • stomach ulcers
  • an unusual or allergic reaction to probenecid, sulfa drugs, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

It may take several months before you see the full effect of this medicine. It is only effective if you keep taking it regularly even if you have an attack of gout. Your prescriber or health care professional will prescribe other tablets to treat an acute attack.

Aspirin and non-steroidal antiinflammatory drugs like ibuprofen can make this medicine less effective. Do not treat yourself for headaches or pain. Ask your doctor or health care professional for advice.

Alcohol may interfere with the effect of this medicine. Avoid alcoholic drinks.

You may need to be on a special diet while taking this medicine. Check with your doctor. Also, ask how many glasses of fluid you need to drink a day. You must not get dehydrated.

This medicine can interfere with some urine glucose tests. If you use such tests talk with your health care professional.

Where should I keep my medicine?

Keep out of the reach of children.

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F). Keep container tightly closed. Throw away any unused medicine after the expiration date.

What does the pill look like?

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Last Updated: May 4, 2012

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