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Generic Name:

pregabalin, Oral capsule

Lyrica

Lyrica

Generic Name: pregabalin, Oral capsule

All Brands

  • Lyrica
SECTION 1 of 5

Highlights for Lyrica

Oral capsule
1

Lyrica is used to treat pain caused by damaged nerves due to diabetes, shingles, and spinal cord injury. This is called neuropathic pain. This drug is also used to treat fibromyalgia (pain all over your body). It can also be used to treat partial onset seizures when taken with other seizure drugs.

2

This drug is available as a capsule and solution that you take by mouth.

3

Lyrica is a brand name for the drug pregabalin. It isn’t available as a generic drug.

4

The more common side effects of this drug include dizziness, sleepiness, trouble concentrating, and blurry vision. They also include dry mouth, weight gain, and swelling of your hands or feet.

5

In some cases, Lyrica can cause serious side effects. These can include heart problems, allergic reactions, severe dizziness or sleepiness, and suicidal thoughts or behaviors (thoughts or actions of harming yourself).

IMPORTANT INFORMATION

Hypersensitivity (allergic) reaction

This drug can cause serious allergic reactions. These include trouble breathing, shortness of breath, and rash, hives, and blisters on your skin. If you have any of these symptoms, stop taking this drug and seek medical help right away.

Suicidal thinking and behavior

This drug can increase your risk of having suicidal thoughts and behavior (thoughts and actions of harming yourself). Talk to your doctor right away if you have any unusual changes in your mood or behavior, new or worsening depression, or thoughts or behaviors of hurting yourself.

Dizziness and drowsiness

This drug can cause dizziness, sleepiness, and blurry vision. It may affect your ability to think, see, or move. You shouldn’t drive, use machinery, or do other tasks that require alertness until you know how this drug affects you.

Abuse warning

This drug can lead to abuse or misuse. Your risk may be greater if you have a history of drug abuse.

What is Lyrica?

This drug is a controlled substance. It’s available as an oral capsule and oral solution.

This medication isn’t available as a generic drug. It’s only available as a brand-name drug called Lyrica.

This drug may be used as part of a combination therapy. This means you may need to take it with other medications.

Why it's used

This drug is used to treat pain caused by damaged nerves due to diabetes, shingles, and spinal cord injury. This is called neuropathic pain. This drug is also used to treat fibromyalgia (pain all over your body). It can also be used to treat partial onset seizures when taken with other seizure drugs.

How it works

This drug belongs to a class of drugs called anticonvulsants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions. 

More Details

How it works

This drug belongs to a class of drugs called anticonvulsants. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

It isn’t known exactly how this drug works. It’s believed to work by calming the damaged or overactive nerves in your body that may cause pain or seizures.

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SECTION 2 of 5

Lyrica Side Effects

Oral capsule

More Common Side Effects

The more common side effects of Lyrica can include:

  • dizziness

  • sleepiness

  • trouble concentrating

  • blurry vision

  • dry mouth

  • weight gain

  • swelling of your hands or feet

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Serious allergic reactions. These reactions may be life-threatening. Symptoms include:

    • swelling of your face, mouth, lips, gums, tongue, throat, or neck
    • trouble breathing
    • rash, hives (raised bumps), or blisters
  • Suicidal thoughts or actions (thoughts or actions of harming yourself). Symptoms include:

    • thoughts of suicide or dying
    • attempts to commit suicide
    • new or worse depression or anxiety
    • feeling agitated or restless
    • panic attacks
    • trouble sleeping
    • new or worse irritability
    • acting aggressive, angry, or violent
    • acting on dangerous impulses
    • mania (an extreme increase in activity and talking)
    • other unusual changes in behavior or mood
  • Heart problems. Symptoms include:

    • swelling of your hands, legs, or feet
    • chest pain
  • Dizziness and sleepiness

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug can cause dizziness, sleepiness, and blurry vision. It may affect your ability to think, see, or move. You shouldn’t drive, use machinery, or do other tasks that require alertness until you know how this drug affects you.

This drug may cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

Lyrica May Interact with Other Medications

Oral capsule

Lyrica can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Alcohol interaction

The use of drinks that contain alcohol can increase the risk of drowsiness and dizziness from Lyrica. You shouldn’t drink alcohol while taking this drug. If you drink alcohol, talk to your doctor.

Medications that might interact with this drug

Drugs that cause more side effects

Taking Lyrica with certain medications may cause more side effects. These drugs include:

  • Diabetes drugs, such as rosiglitazone and pioglitazone. Taking these drugs with Lyrica may cause weight gain or swelling of your hands or feet. If you have heart problems, this can increase your risk of heart failure.
  • Narcotic pain drugs, such as oxycodone. Taking these drugs with Lyrica may cause dizziness and sleepiness.
  • Tranquilizers (drugs that make you sleepy) or drugs for anxiety, such as lorazepam. Taking these drugs with Lyrica may cause dizziness and sleepiness.
  • Blood pressure drugs, such as captopril, enalapril, or lisinopril. Taking these drugs with Lyrica may cause swelling and hives.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Drug warnings
kidney problems
People with kidney problems

If you have kidney problems or a history of kidney disease, you may not be able to clear this drug from your body well. This may increase the levels of this drug in your body and cause more side effects. Your doctor may give you a lower dose to help avoid side effects.

heart problems
People with heart problems

Ask your doctor whether this drug is safe for you if you have heart problems, such as moderate to severe heart failure (NYHA Class III or IV). This drug can make your condition worse. Symptoms may include swelling in your arms, legs, or feet, weight gain, and fluid retention (swelling) in your body. 

mental health issues
People with depression or mental health issues

If you have depression or other mental health or behavioral problems, this drug may increase your risk of suicidal thoughts and behaviors (thoughts or actions of harming yourself). You and your family should watch for new or worsening depression, unusual changes in your mood or behavior, or thoughts or behaviors of harming yourself.

alcohol abuse
People with a history of drug or alcohol abuse

Let your doctor know if you have abused prescription or street drugs or alcohol in the past. This drug is a controlled substance and can lead to misuse or abuse.

plans to father a child
People with plans to father a child

Animal studies have shown that this drug made male animals less fertile and caused sperm to change. Also, birth defects were seen in the babies of male animals who were treated with this drug. It isn’t known if these problems can happen in people who take this drug.

Pregnant women
Pregnant women

This drug is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus. 

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus. 

If you become pregnant while taking this drug, talk to your healthcare provider about registering with the North American Antiepileptic Drug Pregnancy Registry. The purpose of this registry is to collect information about the safety of antiepileptic drugs used during pregnancy.

breast-feeding
Women who are breast-feeding

It isn’t known if this drug passes into breast milk. If it does, it may cause side effects in a child who is breast-fed.  

Talk to your doctor if you breast-feed your child. You may need to decide whether to stop breast-feeding or stop taking this medication.

seniors
For seniors

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

children
For children

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years of age.

call the doctor
When to call the doctor

Call your doctor right away if you become pregnant while taking this drug.

Allergies
Allergies

This drug can cause a severe allergic reaction. Symptoms can include:

  • trouble breathing
  • swelling of your face, mouth, lips, gums, neck, throat, or tongue
  • rash, hives (raised bumps), or blisters 

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

SECTION 4 of 5

How to Take Lyrica (Dosage)

Oral capsule

All possible dosages and drug forms may not be included here. Your dosage, drug form, and how often you take the drug will depend on: 

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Diabetic peripheral neuropathy (nerve pain due to diabetes)

Brand: Lyrica

Form: Oral capsule
Strengths: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, 300 mg
Form: Oral solution
Strengths: 20 mg/mL
Adult dosage (ages 18–64 years)
  • Typical starting dose: 50 mg taken three times per day
  • Dose increases: Your doctor will adjust your dose based on your response to this drug.
  • Maximum dose: 100 mg taken three times per day (a total of 300 mg per day)
Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years of age.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lower dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

Kidney problems: If you have kidney problems, your doctor will lower your dose or change how often you receive this drug. Your dose will be based on your kidney function and the total dose that’s recommended for your specific condition.

Warnings

This drug has been studied at doses up to 600 mg per day. However, it hasn’t been shown to be effective in some people at these higher doses. Also, doses higher than 300 mg per day cause more side effects in some people.

Your doctor may have you take up to 600 mg per day. Your dose depends on how well your pain is controlled and how well you can tolerate this drug without having side effects.

Shingles (nerve pain due to herpes zoster)

Brand: Lyrica

Form: Oral capsule
Strengths: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, 300 mg
Form: Oral solution
Strengths: 20 mg/mL
Adult dosage (ages 18–64 years)
  • Typical starting dose: 75 mg taken two times per day or 50 mg taken three times per day (a total of 150 mg per day)
  • Dose increases: Your doctor will adjust your dose based on your response to this drug.
  • Maximum dose: 300 mg taken two times per day or 200 mg taken three times per day (a total of 600 mg per day)
Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years of age.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lower dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

Kidney problems: If you have kidney problems, your doctor will lower your dose or change how often you receive this drug. Your dose will be based on your kidney function and the total dose that’s recommended for your specific condition.

Warnings

This drug has been studied at doses up to 600 mg per day. However, it hasn’t been shown to be effective in some people at these higher doses. Also, doses higher than 300 mg per day cause more side effects in some people.

Your doctor may have you take up to 600 mg per day. Your dose depends on how well your pain is controlled and how well you can tolerate this drug without having side effects.

Partial onset seizures

Brand: Lyrica

Form: Oral capsule
Strengths: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, 300 mg
Form: Oral solution
Strengths: 20 mg/mL
Adult dosage (ages 18–64 years)
  • Typical starting dose: 75 mg taken two times per day or 50 mg taken three times per day (a total of 150 mg per day)
  • Dose increases: Your doctor will adjust your dose based on your response to this drug.
  • Maximum dose: A total of 600 mg per day
Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years of age.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lower dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

Kidney problems: If you have kidney problems, your doctor will lower your dose or change how often you receive this drug. Your dose will be based on your kidney function and the total dose that’s recommended for your specific condition.

Warnings

This drug has been studied at doses up to 600 mg per day. However, it hasn’t been shown to be effective in some people at these higher doses. Also, doses higher than 300 mg per day cause more side effects in some people.

Your doctor may have you take up to 600 mg per day. Your dose depends on how well your pain is controlled and how well you can tolerate this drug without having side effects.

Fibromyalgia

Brand: Lyrica

Form: Oral capsule
Strengths: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, 300 mg
Form: Oral solution
Strengths: 20 mg/mL
Adult dosage (ages 18–64 years)
  • Typical starting dose: 75 mg taken two times per day
  • Dose increases: Your doctor will adjust your dose based on your response to this drug.
  • Maximum dose: A total of 450 mg per day
Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years of age.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lower dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

Kidney problems: If you have kidney problems, your doctor will lower your dose or change how often you receive this drug. Your dose will be based on your kidney function and the total dose that’s recommended for your specific condition.

Warnings

This drug has been studied at doses up to 600 mg per day. However, it hasn’t been shown to be effective in some people at these higher doses. Also, doses higher than 300 mg per day cause more side effects in some people.

Your doctor may have you take up to 600 mg per day. Your dose depends on how well your pain is controlled and how well you can tolerate this drug without having side effects.

Nerve pain due to spinal cord injury

Brand: Lyrica

Form: Oral capsule
Strengths: 25 mg, 50 mg, 75 mg, 100 mg, 150 mg, 200 mg, 225 mg, 300 mg
Form: Oral solution
Strengths: 20 mg/mL
Adult dosage (ages 18–64 years)
  • Typical starting dose: 75 mg taken two times per day
  • Dose increases: Your doctor will adjust your dose based on your response to this drug.
  • Maximum dose: 300 mg taken two times per day (a total of 600 mg per day)
Child dosage (ages 0–17 years)

This drug hasn’t been studied in children. It shouldn’t be used in people younger than 18 years of age.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

Your doctor may start you on a lower dose or a different dosing schedule. This can help keep levels of this drug from building up too much in your body.

Special considerations

Kidney problems: If you have kidney problems, your doctor will lower your dose or change how often you receive this drug. Your dose will be based on your kidney function and the total dose that’s recommended for your specific condition.

Warnings

This drug has been studied at doses up to 600 mg per day. However, it hasn’t been shown to be effective in some people at these higher doses. Also, doses higher than 300 mg per day cause more side effects in some people.

Your doctor may have you take up to 600 mg per day. Your dose depends on how well your pain is controlled and how well you can tolerate this drug without having side effects.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug comes with serious risks if you don’t take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all

Your pain or seizures won’t go away or may get worse.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. Symptoms may include:

  • dizziness 
  • drowsiness
  • loss of control of body movements
  • tremors (constant shaking)
  • amnesia (forgetfulness or loss of memories)
  • trouble speaking
  • nervousness
  • twitching
  • headache

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room right away.

What to do if you miss a dose

Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working

For peripheral neuropathy, shingles, and nerve pain caused by a spinal cord injury: You should feel less burning, tingling, or numbing pain.

For seizures: Your seizures should be better controlled.

For fibromyalgia: You should feel less pain all over your body.

This drug is used for long-term treatment.

Important considerations for taking this drug
take this drug with or without food
You can take this drug with or without food
timing
Take this drug at the time(s) recommended by your doctor
storage
Store this drug carefully
See Details
medication is refillable
A prescription for this medication is refillable
See Details
Travel
Travel
See Details
Clinical monitoring
Clinical monitoring
See Details
not usually stocked
Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead
prior authorization
Insurance
See Details

Store this drug carefully

  • Store this drug at room temperature. Keep it between 59°F and 86°F (15°C and 30°C). Keep it away from light.
  • Don’t store this medication in moist or damp areas, such as bathrooms.

A prescription for this medication is refillable

You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription.

Travel

When traveling with your medication:

  • Always carry your medication with you. When flying, never put it into a checked bag. Keep it in your carry-on bag.
  • Don’t worry about airport x-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.
  • Be sure to have enough of this drug before you travel.

Clinical monitoring

You and your doctor should monitor certain health issues. This can help make sure you stay safe while you take this drug. These issues include: 

  • Kidney function. Your doctor may do blood tests to check how well your kidneys are working. If your kidneys aren’t working well, your doctor may lower your dose of this drug.
  • Mental health and behavioral problems. You and your doctor should watch for any unusual changes in your behavior and mood. This drug can cause new mental health and behavior problems. It can also make problems you already have worse.

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

SECTION 5 of 5

How Much Does Lyrica Cost?

Oral capsule

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Lowest price for pregabalin

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These prices represent the lowest priced national pharmacies for pregabalin on GoodRx. They may be lower than your insurance.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on December 2, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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