Generic Name: piroxicam, Oral capsule

Feldene

All Brands

  • Feldene
SECTION 1 of 4

Highlights for piroxicam

Oral capsule
1

Piroxicam is an oral medication used to treat rheumatoid arthritis and osteoarthritis.

2

Although you may feel better soon after you start using it, it will take weeks to feel the best results.

3

Piroxicam may increase your risk of heart-related diseases, such as heart attack and stroke. Taking the medication for long periods of time increases your risk.

4
Piroxicam can cause ulcers and stomach bleeding. This can happen at any time during treatment and may not have symptoms. You’re at higher risk if you’re older than 65 years.
IMPORTANT INFORMATION

FDA Warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

May increase risk of heart disease. Piroxicam belongs to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs may increase your risk of heart-related diseases, such as heart attack and stroke. Using piroxicam long-term increases your risk.

May cause ulcers and stomach bleeding that can result in death. Piroxicam can cause ulcers and bleeding in your stomach and intestines. This can happen at any time during treatment and may occur without symptoms. These conditions can be fatal. You’re at higher risk if you’re older than 65 years.

Coronary artery bypass graft surgery. Don’t take piroxicam for pain after coronary artery bypass graft surgery. This may increase your risk of a heart attack and stroke.

May cause high blood pressure

Piroxicam can cause high blood pressure or make your high blood pressure worse. You may need to check your blood pressure level often while taking piroxicam.

May cause water retention and swelling

Watch for symptoms of water retention when taking piroxicam if you have water retention issues or heart problems.

Asthma warning

Piroxicam can cause an asthma attack. If you have asthma that can be triggered by aspirin, don’t take piroxicam. It could also trigger an asthma attack.

Drug Features

Piroxicam is a prescription drug. It’s available as an oral capsule. A generic prescription version is available. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand.  Talk to your healthcare provider to see if the generic will work for you.

Why It's Used

Piroxicam is used to treat symptoms of osteoarthritis and rheumatoid arthritis.

How It Works

It isn’t completely understood how piroxicam works. It belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).

More Details

How It Works

It isn’t completely understood how piroxicam works. It belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever.

NSAIDs may help reduce swelling by lowering levels of prostaglandin, a hormone-like substance that usually causes inflammation.

SECTION 2 of 4

piroxicam Side Effects

Oral capsule

Most Common Side Effects

The most common side effects that occur with piroxicam include:

  • diarrhea

  • dizziness

  • headache

  • heartburn

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • allergic reaction, including

    • skin rash
    • itching or hives
    • swelling of your face, lips, or tongue
  • heart attack or stroke. Symptoms may include:

    • chest pain
    • shortness of breath
    • weakness on one side of your body
    • slurred speech
  • kidney damage. Symptoms may include:

    • decreased urination
    • swelling in your arms, legs, hands, or feet
  • heart failure. Symptoms may include:

    • unusual weight gain
    • swelling in your arms, legs, hands, or feet
  • stomach problems, such as ulcers and bleeding. Symptoms may include:

    • stomach pain or upset stomach
    • black, tarry stools
    • vomiting blood
  • liver problems. Symptoms may include:

    • yellowing of your skin or the whites of your eyes
    • flu-like symptoms, such as body aches, fever, nausea, and vomiting
    • tiredness
    • pain in the upper part of your stomach
    • itching
  • skin reactions. Symptoms may include:

    • reddening, blistering, or peeling skin
Pharmacist's Advice
Healthline Pharmacist Editorial Team

Piroxicam does not cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

piroxicam May Interact with Other Medications

Oral capsule

Piroxicam can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interactions

Combining piroxicam and alcohol increases your risk of ulcer or stomach bleeding.

Medications That Might Interact with This Drug

Nonsteroidal anti-inflammatory drugs
  • aspirin
  • ibuprofen
  • naproxen

Taking NSAIDs together may increase side effects, including stomach pain.

Disease-modifying anti-inflammatory drug
  • methotrexate

Taking piroxicam together with methotrexate may lead to toxic levels of of methotrexate. This may cause side effects like nausea, vomiting, diarrhea, mouth sores, fever, and hair loss.

Blood pressure drugs

These include:

  • angiotensin-converting enzyme (ACE) inhibitors
  • diuretics

Piroxicam might make your blood pressure medications not work as well.

Anticoagulant, blood thinner
  • warfarin

Combining these medications increases your risk of stomach and intestinal bleeding.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with asthma

Piroxicam can cause an asthma attack. If you have asthma that can be triggered by aspirin, you shouldn’t use piroxicam. It may have the same effect as aspirin.

People with ulcer or stomach bleeding

This medication increases your risk of stomach or intestinal bleeding. If you have a history of ulcer or stomach or intestinal bleeding and take piroxicam, watch for symptoms of these conditions. Symptoms include stomach pain, black and tarry stools, and vomiting blood.

People with kidney disease

Piroxicam can cause kidney damage if you use it for a long time. If you have serious kidney disease, you shouldn’t use this drug.

People with high blood pressure

Piroxicam can cause high blood pressure or make your high blood pressure worse. You may need to check your blood pressure level often while taking piroxicam.

Pregnant women

Piroxicam is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Avoid taking piroxicam during your third trimester of pregnancy. It may cause harm to your fetus.

Speak with your doctor if you’re pregnant or plan to become pregnant. 

Women who are nursing

Piroxicam passes through breast milk and may cause side effects in a breastfeeding child. It’s not recommended to breastfeed while taking this medication. 

For Seniors

If you’re older than 65 years, your body may process this drug more slowly. Your doctor may start you on a lowered dose so that too much of the drug doesn’t build up in your body. Too much of the drug in your body can be toxic.

For Children

The safety and effectiveness of piroxicam haven’t been established in people younger than 18 years.

Allergies

Piroxicam can cause severe allergic reaction. Symptoms may include:

  • shortness of breath or trouble breathing
  • chest pain
  • weakness in one part or side of your body
  • difficulty speaking
  • swelling of your face or throat

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be dangerous.

SECTION 4 of 4

How to Take piroxicam (Dosage)

Oral capsule

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Osteoarthritis

Brand: Feldene

Form: Oral Capsule
Strength: 10 mg and 20 mg
Adult Dosage (ages 18 years and older)

20 mg taken once per day. You may take 10 mg two times per day in evenly spaced doses.

Child Dosage (ages 0-17 years)

Dosage for people younger than 18 years hasn’t been established.

Rheumatoid arthritis

Brand: Feldene

Form: Oral Capsule
Strength: 10 mg and 20 mg
Adult Dosage (ages 18 years and older)

20 mg taken once per day. You may take 10 mg two times per day in evenly spaced doses.

Child Dosage (ages 0-17 years)

Dosage for people younger than 18 years hasn’t been established.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

If You Stop or Miss Doses

If you stop taking this medication, miss doses, or don’t take it on schedule, your symptoms of arthritis may get worse.

If You Take Too Much

If you take too much piroxicam, you may experience:

  • fatigue
  • drowsiness
  • nausea
  • vomiting
  • stomach pain
  • stomach bleeding

In rare cases, taking too much can cause dangerous allergic reactions, high blood pressure, kidney failure, difficulty breathing, or coma. Get immediate medical attention if you take or think you’ve taken too much.

What To Do If You Miss a Dose

If you miss a dose, take it as soon as you remember. However, if it’s just a few hours until  your next dose, wait and take a single dose at the usual time. Never try to catch up by taking two doses at once. This could result in toxic side effects.

How Can I Tell if the Drug is Working?

You may be able to tell this drug is working if you experience reduced arthritis pain.

This is a short-term treatment.

This is an oral capsule, so it shouldn’t be cut or crushed

But if you have trouble swallowing the capsule, you can open it up and spread its contents on applesauce or have it given through a feeding tube.

Keep this medication in temperatures from 59–86°F (15–30°C)

Keep container tightly closed and out of the reach of children. Protect this medication from light. Throw away any unused medicine after the expiration date.

Travel

When traveling with your medication:

  • Always carry it with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s preprinted label to identify the medication.  Keep the original prescription-labeled bottle with you when traveling.

Clinical Monitoring

Your doctor may perform tests to check your health and make sure the drug is working for you. They include:

  • blood test
  • kidney function test
  • liver function test

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for piroxicam.

Are There Any Alternatives?

There are other drugs available to treat your condition. Some may be more suitable for you than others. Talk to your doctor about possible alternatives.

Content developed in collaboration with Chending Wu (UIC)

Medically reviewed by Darren Hein (Creighton) on May 12, 2015

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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