Generic Name: oxaprozin, Oral tablet

Daypro

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  • Daypro
SECTION 1 of 4

Highlights for oxaprozin

Oral tablet
1

Oxaprozin is an oral medication used to treat rheumatoid arthritis, juvenile rheumatoid arthritis, and osteoarthritis.

2

This medication may increase your risk of heart-related diseases, such as heart attack and stroke. The risk may be greater the longer you take this medication.

3

Try to stay out of the sun when taking oxaprozin. Taking this drug makes you more sensitive to effects of the sun. If you can’t avoid the sun, wear sunscreen and protective clothing.

4

Oxaprozin can cause ulcers and stomach bleeding without symptoms. Smoking cigarettes or drinking alcohol can make these conditions worse.

IMPORTANT INFORMATION

FDA Warning

This drug has a Black Box Warning. This is the most serious warning from the Food and Drug Administration (FDA). A black box warning alerts doctors and patients to potentially dangerous effects.

Heart disease risk. Oxaprozin belongs to a drug class called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs may increase your risk of heart-related diseases, such as heart attack and stroke. Taking this drug over a long period increases this risk.

May cause ulcers and stomach bleeding. Oxaprozin can cause ulcers and bleeding in your stomach and intestines. This can happen at any time during treatment and may not cause symptoms. Smoking cigarettes or drinking alcohol can make these conditions worse.

Coronary artery bypass graft surgery. Oxaprozin shouldn’t be used for pain after coronary artery bypass graft surgery. Taking it could increase your risk for a heart attack or stroke.

May cause allergic reaction

This medication can cause a severe allergic reaction. Symptoms may include:

  • hives
  • trouble breathing
  • swelling of your throat or tongue
  • rash
  • chest pain

Don’t take oxaprozin if you’ve experienced any of these allergic-type reactions or asthma after taking aspirin or other NSAIDs.

May cause high blood pressure

Oxaprozin can lead to increased blood pressure in people who don’t already have high blood pressure.

May cause kidney damage

Using this medication long term can cause kidney damage. Seniors are at increased risk.

Drug Features

Oxaprozin is a prescription drug. It’s available as an oral tablet. A generic version is available. Generic drugs usually cost less. In some cases they may not be available in every strength or form as the brand.  Talk to your healthcare provider to see if the generic will work for you.

Why It's Used

Oxaprozin is used to treat symptoms of rheumatoid arthritis, juvenile rheumatoid arthritis, and osteoarthritis.

How It Works

It isn’t completely understood how oxaprozin works. It belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs).

More Details

How It Works

It isn’t completely understood how oxaprozin works. It belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs). NSAIDs help reduce pain, inflammation, and fever.

NSAIDs may help reduce swelling by lowering levels of prostaglandin, a hormone-like substance that usually causes inflammation.

SECTION 2 of 4

oxaprozin Side Effects

Oral tablet

Most Common Side Effects

The most common side effects that occur with oxaprozin include:

  • diarrhea

  • dizziness

  • headache

  • heartburn

Serious Side Effects

If you experience any of these serious side effects, call your doctor right away. If your symptoms are potentially life threatening, or if you think you’re experiencing a medical emergency, call 9-1-1.

  • allergic reactions. Examples include:

    • skin rash
    • itching or hives
    • swelling of your face, lips, or tongue
  • heart problems. Symptoms may include:

    • chest pain
    • unexplained weight gain or swelling
  • bleeding or peptic ulcers. Symptoms may include:

    • serious stomach pain
    • nausea and vomiting
    • blood in your urine or vomit
    • black or bloody stools
  • stroke. Symptoms may include:

    • difficulty speaking
    • weakness on one side of your body
  • liver problems. Symptoms may include:

    • yellowing of your skin or whites of your eyes
    • feeling unusually weak or tired
  • difficulty breathing or wheezing

  • redness, blistering, peeling, or loosening of your skin, including on the inside of your mouth

  • unusual bleeding or bruising

Pharmacist's Advice
Healthline Pharmacist Editorial Team

Oxaprozin does not cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 4

oxaprozin May Interact with Other Medications

Oral tablet

Oxaprozin can interact with other medications, herbs, or vitamins you might be taking. That’s why your doctor should manage all of your medications carefully. If you’re curious about how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Note: You can reduce your chances of drug interactions by having all of your prescriptions filled at the same pharmacy. That way, a pharmacist can check for possible drug interactions.

Alcohol Interactions

Combining oxaprozin with alcohol increases your risk of ulcer or stomach bleeding.

Medications That Might Interact with This Drug

Nonsteroidal anti-inflammatory drug
  • aspirin

Taking aspirin and oxaprozin together may increase toxic side effects from aspirin. These may include nausea, vomiting, sweating, and ringing in your ears.

Disease-modifying antirheumatic drug
  • methotrexate

Combining these drugs may lead to a higher than usual level of methotrexate in your body. This may cause more side effects, including nausea, vomiting, diarrhea, mouth sores, fever, and hair loss.

Blood pressure drugs
  • angiotensin-converting enzyme (ACE) inhibitors
  • diuretics

Oxaprozin might make your blood pressure medications not work as well.

Anticoagulant, blood thinner
  • warfarin

Combining these medications increases your risk of stomach and intestinal bleeding.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.

People with asthma

If you have aspirin-sensitive asthma and take oxaprozin, you’re at increased risk of a serious, potentially fatal, asthma attack. If you have asthma that can be triggered by aspirin, you shouldn’t use oxaprozin. Oxaprozin works similarly to aspirin.

People with liver disease

You may need to be closely monitored or stop taking this drug if you have serious liver disease or have had abnormal liver test results. This drug is processed in your liver. If your liver function is decreased, you may not be able to process the drug as quickly. This could lead to a build up of the drug in your body, which could cause toxic side effects.

People with ulcer or stomach bleeding

This drug increases your risk of stomach or intestinal bleeding.

Pregnant women

Oxaprozin is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Avoid taking this drug in the third trimester. It may cause harm to your fetus.

Speak with your doctor if you’re pregnant or plan to become pregnant before you take this drug.

Women who are nursing

It isn’t known if oxaprozin passes through breast milk. If it does, it may cause side effects in child who is breastfed. You and your doctor may decide whether you’ll take oxaprozin or breastfeed.

For Seniors

People older than 65 years may have reduced kidney function. This may cause oxaprozin to build up in the body, which can lead to toxic effects. If you’re over 65 years old, your doctor may start you on a lowered dose.

For Children

For rheumatoid arthritis and osteoarthritis, the safety and effectiveness of oxaprozin haven’t been established in people younger than 18 years.

Allergies

Oxaprozin can cause severe allergic reaction. Symptoms may include:

  • skin rash
  • itching or hives
  • swelling of your face, lips, or tongue

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be dangerous.

SECTION 4 of 4

How to Take oxaprozin (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What Are You Taking This Medication For?

Rheumatoid arthritis

Brand: Daypro Alta

Form: Oral Tablet
Strength: 600 mg
Adult Dosage (ages 18 years and older)
  • two 600 mg tablets taken once per day.
  • If you can’t tolerate that amount in one dose, your doctor may change your dose to one 600 mg tablet taken two times per day as needed.
  • Don’t take more than 1,800 mg per day or 26 mg/kg per day, whichever is less.
  • If you weigh less than 110 pounds (50 kg) or have mild arthritis, your doctor may start your dose at 600 mg taken once per day. This may reduce your risk of side effects.
Child Dosage (ages 0-17 years)

A safe and effective dose hasn’t been determined for this use.

Warnings

Oxaprozin is approved for use in children with juvenile rheumatoid arthritis. It shouldn’t be used in children for other conditions.

Osteoarthritis

Brand: Daypro Alta

Form: Oral Tablet
Strength: 600 mg
Adult Dosage (ages 18 years and older)
  • two 600 mg tablets taken once per day.
  • If you can’t tolerate that amount in one dose, your doctor may change your dose to one 600 mg tablet taken two times per day as needed.
  • Don’t take more than 1,800 mg per day or 26 mg/kg per day, whichever is less.
  • If you weigh less than 110 pounds (50 kg) or have mild arthritis, your doctor may start your dose at 600 mg taken once per day. This may reduce your risk of side effects.
Child Dosage (ages 0-17 years)

A safe and effective dose hasn’t been determined for this use.

Warnings

Oxaprozin is approved for use in children with juvenile rheumatoid arthritis. It shouldn’t be used in children for other conditions.

Juvenile rheumatoid arthritis

Brand: Daypro Alta

Form: Oral Tablet
Strength: 600 mg
Child Dosage (ages 0-17 years)
  • Dosage for children is based on their weight.
  • 48–69 pounds (22–31 kg): Take one 600 mg tablet once per day.
  • 70–120 pounds (32–54 kg): Take one and one half 600 mg tablet for a total dose of 900 mg once per day.
  • 121 pounds or more (55 kg or more): Take two 600 mg tablets once per day.

Warnings

Oxaprozin is approved for use in children with juvenile rheumatoid arthritis. It shouldn’t be used in children for other conditions.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Healthline Pharmacist Editorial Team

If You Stop or Miss Doses

If you stop taking this medication, miss doses, or don’t take it on schedule, your symptoms of arthritis may get worse.

If You Take Too Much

If you take too much oxaprozin, you may experience:

  • fatigue
  • drowsiness
  • nausea
  • vomiting
  • stomach pain
  • stomach bleeding

In rare cases, this can cause dangerous allergic reactions, high blood pressure, kidney failure, difficulty breathing, or coma. Get immediate medical attention if you take or think you’ve taken too much oxaprozin.

What to Do If You Miss a Dose

If you miss a dose, take it as soon as you remember. However, if it’s just a few hours until your next dose, wait and take a single dose at the usual time. Never try to catch up by taking two tablets at once. This could result in toxic side effects.

How Can I Tell if the Drug is Working?

You may be able to tell this drug is working if your pain or swelling gets better.

Oxaprozin is a short-term drug.

You can take this drug with or without food

Taking it with food may limit upset stomach.

Store in temperatures from 59–86°F (15–30°C)

Keep the container tightly closed. Protect this drug from light. Throw away any unused medicine after the expiration date.

Travel

When traveling with your medication:

  • Always carry it with you or in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt this medication.
  • You may need to show your pharmacy’s preprinted label to identify the medication. Keep the original prescription-labeled bottle with you when traveling.

Clinical Monitoring

Your doctor will perform tests to check your health and make sure the drug is working for you. These include:

  • blood test
  • kidney function test
  • liver function test

Sun Sensitivity

Oxaprozin can make you more sensitive to the sun. If you can’t avoid being in the sun, wear protective clothing and use sunscreen.

Insurance

Many insurance companies will require a prior authorization before they approve the prescription and pay for oxaprozin.


Show Sources

Content developed in collaboration with Chending Wu (UIC)

Medically reviewed by Darren Hein (Creighton) on May 6, 2015

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.

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