Generic Name: ondansetron, Oral tablet

Zofran

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  • Zofran
SECTION 1 of 4

Highlights for ondansetron

Oral tablet
1
ONDANSETRON (on DAN se tron) is used to treat nausea and vomiting caused by chemotherapy. It is also used to prevent or treat nausea and vomiting after surgery.
2
This drug also comes in other forms, including Parenteral SolutionOral SolutionOrally disintegrating solid
3 4 5
Talk to your healthcare provider if you have any of these conditions.
6
Know what to watch for and get tips for reducing your risks while taking this drug.
SECTION 2 of 4

ondansetron Side Effects

Oral tablet

Side effects that you should report to your doctor or health care professional as soon as possible:

  • allergic reactions like skin rash, itching or hives, swelling of the face, lips or tongue
  • breathing problems
  • confusion
  • dizziness
  • fast or irregular heartbeat
  • feeling faint or lightheaded, falls
  • fever and chills
  • loss of balance or coordination
  • seizures
  • sweating
  • swelling of the hands or feet
  • tightness in the chest
  • tremors
  • unusually weak or tired

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • constipation or diarrhea
  • headache
SECTION 3 of 4

ondansetron May Interact with Other Medications

Oral tablet

Do not take this medicine with any of the following medications:

  • apomorphine
  • certain medicines for fungal infections like fluconazole, itraconazole, ketoconazole, posaconazole, voriconazole
  • cisapride
  • dofetilide
  • dronedarone
  • pimozide
  • thioridazine
  • ziprasidone

This medicine may also interact with the following medications:

  • carbamazepine
  • certain medicines for depression, anxiety, or psychotic disturbances
  • fentanyl
  • linezolid
  • MAOIs like Carbex, Eldepryl, Marplan, Nardil, and Parnate
  • methylene blue (injected into a vein)
  • other medicines that prolong the QT interval (cause an abnormal heart rhythm)
  • phenytoin
  • rifampicin
  • tramadol
SECTION 4 of 4

How to Use ondansetron

Oral tablet

Take this medicine by mouth with a glass of water. Follow the directions on your prescription label. Take your doses at regular intervals. Do not take your medicine more often than directed.

Talk to your pediatrician regarding the use of this medicine in children. Special care may be needed.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • heart disease
  • history of irregular heartbeat
  • liver disease
  • low levels of magnesium or potassium in the blood
  • an unusual or allergic reaction to ondansetron, granisetron, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

Check with your doctor or health care professional right away if you have any sign of an allergic reaction.

Where should I keep my medicine?

Keep out of the reach of children.

Store between 2 and 30 degrees C (36 and 86 degrees F). Throw away any unused medicine after the expiration date.

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Last Updated: September 24, 2014

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