Generic Name: olanzapine, Orally disintegrating solid

Zyprexa Zydis

All Brands

  • Zyprexa Zydis
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Highlights for olanzapine

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OLANZAPINE (oh LAN za peen) is used to treat schizophrenia, psychotic disorders, and bipolar disorder. Bipolar disorder is also known as manic-depression.
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This drug also comes in other forms, including Parenteral SolutionOral tabletParenteral Suspension
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Talk to your healthcare provider if you have any of these conditions.
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Know what to watch for and get tips for reducing your risks while taking this drug.
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olanzapine Side Effects

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Side effects that you should report to your doctor or health care professional as soon as possible:

  • difficulty breathing
  • difficulty in speaking or swallowing
  • excessive thirst and/or hunger
  • fast heartbeat (palpitations)
  • fever or chills, sore throat
  • frequently needing to urinate
  • inability to control muscle movements in the face, hands, arms, or legs
  • painful or prolonged erections
  • restlessness or need to keep moving
  • seizures (convulsions)
  • skin rash
  • stiffness, spasms
  • swelling of face or legs
  • tremors or trembling
  • weight gain

Side effects that usually do not require medical attention (report to your doctor or health care professional if they continue or are bothersome):

  • changes in sexual desire
  • constipation
  • drowsiness
  • lowered blood pressure
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olanzapine May Interact with Other Medications

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Do not take this medicine with any of the following medications:

  • certain antibiotics like grepafloxacin and sparfloxacin
  • certain phenothiazines like chlorpromazine, mesoridazine, and thioridazine
  • cisapride
  • clozapine
  • droperidol
  • halofantrine
  • levomethadyl
  • pimozide

This medicine may also interact with the following medications:

  • carbamazepine
  • charcoal
  • fluvoxamine
  • levodopa and other medicines for Parkinson's disease
  • medicines for diabetes
  • medicines for high blood pressure
  • medicines for mental depression, anxiety, other mood disorders, or sleeping problems
  • omeprazole
  • rifampin
  • ritonavir
  • tobacco from cigarettes
Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
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How to Use olanzapine

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Take this medicine by mouth. Follow the directions on the prescription label. Leave the tablet in the foil package until you are ready to take it. Do not push the tablet through the blister pack. Peel open the package with dry hands and place the tablet on your tongue. The tablet will dissolve rapidly and be swallowed in your saliva. While you may take these tablets with food or water, it is not necessary to do so. Take your medicine at regular intervals. Do not take it more often than directed. Do not stop taking except on the advice of your doctor or health care professional.

A special MedGuide will be given to you by the pharmacist with each new prescription and refill. Be sure to read this information carefully each time.

Talk to your pediatrician regarding the use of this medicine in children. While this drug may be prescribed for children as young as 13 years for selected conditions, precautions do apply.

What should I tell my health care provider before I take this medicine?

They need to know if you have any of these conditions:

  • breast cancer or history or breast cancer
  • cigarette smoker
  • dementia
  • diabetes mellitus, high blood sugar or a family history of diabetes
  • difficulty swallowing
  • glaucoma
  • heart disease, irregular heartbeat, or previous heart attack
  • history of brain tumor or head injury
  • kidney or liver disease
  • low blood pressure or dizziness when standing up
  • Parkinson's disease
  • prostate trouble
  • seizures (convulsions)
  • suicidal thoughts, plans, or attempt by you or a family member
  • an unusual or allergic reaction to olanzapine, other medicines, foods, dyes, or preservatives
  • pregnant or trying to get pregnant
  • breast-feeding
What if I miss a dose?

If you miss a dose, take it as soon as you can. If it is almost time for your next dose, take only that dose. Do not take double or extra doses.

What should I watch for while using this medicine?

Visit your doctor or health care professional for regular checks on your progress. It may be several weeks before you see the full effects of this medicine. Notify your doctor or health care professional if your symptoms get worse, if you have new symptoms, if you are having an unusual effect from this medicine, or if you feel out of control, very discouraged or think you might harm yourself or others.

Do not suddenly stop taking this medicine. You may need to gradually reduce the dose. Ask your doctor or health care professional for advice.

You may get dizzy or drowsy. Do not drive, use machinery, or do anything that needs mental alertness until you know how this medicine affects you. Do not stand or sit up quickly, especially if you are an older patient. This reduces the risk of dizzy or fainting spells.

Avoid alcoholic drinks. Alcohol can increase dizziness and drowsiness with olanzapine.

Do not treat yourself for colds, diarrhea or allergies without asking your doctor or health care professional for advice. Some ingredients can increase possible side effects.

Your mouth may get dry. Chewing sugarless gum or sucking hard candy, and drinking plenty of water will help.

This medicine can reduce the response of your body to heat or cold. Dress warm in cold weather and stay hydrated in hot weather. If possible, avoid extreme temperatures like saunas, hot tubs, very hot or cold showers, or activities that can cause dehydration such as vigorous exercise.

If you notice an increased hunger or thirst, different from your normal hunger or thirst, or if you find that you have to urinate more frequently, you should contact your health care provider as soon as possible. You may need to have your blood sugar monitored. This medicine may cause changes in your blood sugar levels. You should monitor you blood sugar frequently if you have diabetes.

If you smoke, tell your doctor if you notice this medicine is not working well for you. Talk to your doctor if you are a smoker or if you decide to stop smoking.

Where should I keep my medicine?

Keep out of the reach of children.

Store at controlled room temperature between 15 and 30 degrees C (59 and 86 degrees F). Protect from light and moisture. Throw away any unused medicine after the expiration date.

What does the pill look like?

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Last Updated: February 25, 2014

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