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Generic Name:

nisoldipine, Oral tablet

All Brands

  • Sular
SECTION 1 of 5

Highlights for nisoldipine

Oral tablet
1

Nisoldipine is used to treat high blood pressure (hypertension). It can be taken alone or in combination with other blood pressure medications.

2

This drug comes in the form of an extended-release tablet that you take by mouth. Extended-release tablets slowly release the medication into your bloodstream over time.

3

Nisoldipine is a generic drug. It’s also available as a brand-name drug called Sular.

4

The more common side effects that can occur with nisoldipine include headache, dizziness, nausea, or swelling of the ankles, feet, or hands. They also include chest pain, sore throat, nasal congestion, or rash.

5

Don’t eat grapefruit or drink grapefruit juice if you’re taking nisoldipine. Doing so can increase the level of the drug in your body and increase your risk of side effects.

IMPORTANT INFORMATION

Allergic reaction to calcium channel blockers

Nisoldipine is a type of drug called a calcium channel blocker. If you’ve ever had an allergic reaction to any calcium channel blocker, you shouldn’t use this drug. You may have an allergic reaction again, which could be fatal (cause death).

Low blood pressure

Some people can develop extremely low blood pressure when starting this drug or when their dosage is increased. This is more likely to occur when nisoldipine is taken with other drugs that lower blood pressure. Your doctor will need to monitor your blood pressure closely.

What is nisoldipine?

Nisoldipine is a prescription drug. It’s available as an extended-release tablet that you take by mouth.

Nisoldipine is used to treat high blood pressure. It may be used as part of a combination therapy. This means you may need to take it with other blood pressure medications.

Nisoldipine is available as a brand-name drug called Sular. It’s also available as a generic drug. Generic drugs usually cost less. In some cases, they may not be available in every strength or form as the brand-name version. Talk to your doctor to see if the generic version will work for you.

Why it's used

Nisoldipine is used to treat high blood pressure. Lowering your blood pressure can help reduce your risk of heart attack or stroke.

How it works

Nisoldipine belongs to a class of drugs called calcium channel blockers.

More Details

How it works

Nisoldipine belongs to a class of drugs called calcium channel blockers. A class of drugs is a group of medications that work in a similar way. These drugs are often used to treat similar conditions.

Nisoldipine helps relax your blood vessels so that blood can flow more easily to your heart. This helps lower your blood pressure.

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SECTION 2 of 5

nisoldipine Side Effects

Oral tablet

More Common Side Effects

The more common side effects that can occur with use of nisoldipine include:

  • edema (swelling caused by fluid buildup) in the lower legs, feet, or hands

  • headache

  • dizziness

  • sore throat

  • nasal congestion

  • chest pain

  • nausea

  • rash

If these effects are mild, they may go away within a few days or a couple of weeks. If they’re more severe or don’t go away, talk to your doctor or pharmacist.

Serious Side Effects

Call your doctor right away if you have serious side effects. Call 9-1-1 if your symptoms feel life-threatening or if you think you’re having a medical emergency. Serious side effects and their symptoms can include the following:

  • Allergic reaction. Symptoms can include:

    • swelling of your face, eyes, lips, throat, or tongue
    • trouble breathing
    • trouble swallowing
    • severe rash
  • Low blood pressure. Symptoms can include:

    • severe dizziness
    • lightheadedness
    • fainting.
  • Increased chest pain

  • Heart attack. Symptoms can include:

    • crushing chest pain
    • fast heartbeat
    • shortness of breath
    • sweating

    Heart attack is rare, but it’s more likely to occur when you first start taking this drug or when your doctor increases your dose. It’s also more likely if you already have heart disease.

Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

This drug doesn't cause drowsiness.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this information includes all possible side effects. This information is not a substitute for medical advice. Always discuss possible side effects with a healthcare provider who knows your medical history.
SECTION 3 of 5

nisoldipine May Interact with Other Medications

Oral tablet

Nisoldipine can interact with other medications, vitamins, or herbs you may be taking. An interaction is when a substance changes the way a drug works. This can be harmful or prevent the drug from working well.

To help avoid interactions, your doctor should manage all of your medications carefully. Be sure to tell your doctor about all medications, vitamins, or herbs you’re taking. To find out how this drug might interact with something else you’re taking, talk to your doctor or pharmacist.

Food interactions

Don’t eat grapefruit or drink grapefruit juice if you’re taking nisoldipine. Doing so can increase the level of the drug in your body and increase your risk of side effects. Your doctor will likely tell you to avoid grapefruit at least 3 days before starting to take nisoldipine.

Alcohol interaction

Try to avoid drinks that contain alcohol while taking this drug. Alcohol can lower your blood pressure. When it’s used with nisoldipine, it raises your risk of extremely low blood pressure.

Medications that might interact with this drug

Antibiotics

Taking certain antibiotics with nisoldipine can cause higher levels of the drug in your body. This raises your risk of side effects from nisoldipine. Examples of these drugs include:

  • clarithromycin
  • erythromycin

Antifungal drugs

Taking certain antifungal drugs with nisoldipine can cause higher levels of the drug in your body. This raises your risk of side effects from nisoldipine. Examples of these drugs include:

  • fluconazole
  • ketoconazole
  • itraconazole
  • voriconazole

Antiseizure drugs

Taking certain antiseizure drugs with nisoldipine can cause lower levels of the drug in your body. This can make nisoldipine less effective. Examples of these drugs include:

  • phenytoin
  • carbamazepine

Stomach acid drugs

Cimetidine is used to treat problems with excess stomach acid. Using this drug with nisoldipine can increase the levels of nisoldipine in your body. This raises your risk of side effects.

Other drugs

Beta-blockers are used to treat many conditions. These include high blood pressure, migraines, and heart failure. Using these drugs with nisoldipine may slow your heart rate and cause extremely low blood pressure. Examples of beta-blockers include:

  • atenolol
  • metoprolol
  • nadolol
  • propranolol

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs interact differently in each person, we cannot guarantee that this information includes all possible interactions. This information is not a substitute for medical advice. Always speak with your healthcare provider about possible interactions with all prescription drugs, vitamins, herbs and supplements, and over-the-counter drugs that you are taking.
Nisoldipine warnings
allergies
People who are allergic to calcium channel blockers

If you’ve had an allergic reaction to any calcium channel blocker, you shouldn’t use nisoldipine. You may have an allergic reaction again, which could be fatal (cause death). 

heart disease or coronary artery disease
People with heart disease or coronary artery disease (CAD)

When starting to take this drug or increasing your dose, you may be at increased risk for worsening chest pain or a heart attack.

heart failure
People with heart failure

Nisoldipine hasn’t been studied in patients with heart failure. Talk to your doctor about whether this drug is safe for you.

liver disease
People with liver disease

Your liver clears this drug from your blood. If your liver isn’t working right, the level of nisoldipine in your blood may become too high. Talk to your doctor about whether this drug is safe for you.

pregnant women
Pregnant women

Nisoldipine is a category C pregnancy drug. That means two things:

  1. Research in animals has shown adverse effects to the fetus when the mother takes the drug.
  2. There haven’t been enough studies done in humans to be certain how the drug might affect the fetus.

Talk to your doctor if you’re pregnant or planning to become pregnant. This drug should only be used if the potential benefit justifies the potential risk to the fetus.

breastfeeding
Women who are breast-feeding

It isn’t known if nisoldipine passes into breast milk. If it does, it might cause serious side effects in children who are breast-fed. Talk to your doctor if you breast-feed your child. You should decide whether to stop breast-feeding or stop taking this medication.

for seniors
For seniors

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This raises your risk of side effects.

for children
For children

This medication hasn’t been studied in children. It shouldn’t be used in people under the age of 18 years.

call doctor
When to call the doctor

Call your doctor right away if you become pregnant while taking this drug.

allergies
Allergies

Nisoldipine can cause a severe allergic reaction. Symptoms can include:

  • swelling of your throat or tongue
  • trouble breathing
  • chest tightness
  • hives or rash

If you have an allergic reaction, call your doctor or local poison control center right away. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room.

Don’t take this drug again if you’ve ever had an allergic reaction to it. Taking it again could be fatal (cause death).

SECTION 4 of 5

How to Take nisoldipine (Dosage)

Oral tablet

All possible dosages and forms may not be included here. Your doctor will tell you what dosage is right for you. Your dose, form, and how often you take it will depend on:

  • your age
  • the condition being treated
  • how severe your condition is
  • other medical conditions you have
  • how you react to the first dose

What are you taking this medication for?

Hypertension

Brand: Sular

Form: Extended-release tablet
Strengths: 8.5 mg, 17 mg, 34 mg

Generic: nisoldipine

Form: Extended-release tablet
Strengths: 8.5 mg, 17 mg, 20 mg, 25.5 mg, 30 mg, 34 mg, 40 mg
Adult dosage (ages 18–64 years)

The typical dose is 17–34 mg once daily.

Child dosage (ages 0–17 years)

This medication hasn’t been studied in children. It shouldn’t be used in people under the age of 18 years.

Senior dosage (ages 65 years and older)

The kidneys of older adults may not work as well as they used to. This can cause your body to process drugs more slowly. As a result, more of a drug stays in your body for a longer time. This increases your risk of side effects.

Your doctor may start you on a lowered dose or a different medication schedule. This can help keep levels of this drug from building up too much in your body. Your starting dose shouldn’t be greater than 8.5 mg once daily.

Special considerations

People with liver disease: Drugs are processed in your body by your liver. If you have liver disease, more nisoldipine may stay in your body longer. This puts you at higher risk of side effects. Talk to your doctor about whether this drug is safe for you. If it is, your starting dose shouldn’t be greater than 8.5 mg once daily.

Disclaimer: Our goal is to provide you with the most relevant and current information. However, because drugs affect each person differently, we cannot guarantee that this list includes all possible dosages. This information is not a substitute for medical advice. Always to speak with your doctor or pharmacist about dosages that are right for you.
Pharmacist's Advice
Clinical Associate Professor, University of Illinois at Chicago College of Pharmacy

Nisoldipine comes with serious risks if you don't take it as prescribed.

If you stop taking the drug suddenly or don’t take it at all

Your blood pressure may increase. This raises your risk of health problems such as heart attack or stroke. This risk may be further increased if you stop taking the drug suddenly.

If you miss doses or don’t take the drug on schedule

Your medication may not work as well or may stop working completely. For this drug to work well, a certain amount needs to be in your body at all times.

If you take too much

You could have dangerous levels of the drug in your body. An overdose of this drug can cause extremely low blood pressure, with symptoms that include:

  • dizziness
  • lightheadedness
  • fainting

If you think you’ve taken too much of this drug, call your doctor or local poison control center. If your symptoms are severe, call 9-1-1 or go to the nearest emergency room right away. 

What to do if you miss a dose

Take your dose as soon as you remember. But if you remember just a few hours before your next scheduled dose, take only one dose. Never try to catch up by taking two doses at once. This could result in dangerous side effects.

How to tell if the drug is working

Your blood pressure should go down. Your doctor can check your blood pressure, or you can do it using a home blood pressure monitor.

Nisoldipine is used for long-term treatment.

Important considerations for taking nisoldipine
do not take on empty stomach
You should take nisoldipine on an empty stomach
timing
You should take nisoldipine either 1 hour before a meal, or 2 hours after a meal
do not crush or cut or chew
Don’t crush, cut, or chew these tablets. Swallow them whole.
storage
Store this drug carefully
See Details
refillable
Prescription is refillable
travel
Travel
See Details
self-management
Self-management
See Details
clinical monitoring
Clinical monitoring
See Details
diet considerations
Your diet
See Details
not usually stocked
Not every pharmacy stocks this drug. When filling your prescription, be sure to call ahead.
hidden costs
Hidden costs
See Details
prior authorization
Insurance
See Details

Store this drug carefully

  • Store nisoldipine at room temperature between 68°F and 77°F (20°C and 25°C).
  • Keep it in the original container with the lid tightly closed. Keep it away from light.
  • Don’t store this medication in moist or damp areas, such as bathrooms.

Travel

When traveling with your medication:

  • Always carry your medication with you, such as in your carry-on bag.
  • Don’t worry about airport X-ray machines. They can’t hurt your medication.
  • You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled box with you.
  • Don’t put this medication in your car’s glove compartment or leave it in the car. Be sure to avoid doing this when the weather is very hot or very cold.

Self-management

Your doctor may ask you to measure and record your daily blood pressure between office visits. This will help you see how well your blood pressure is being controlled. You can do this using a home blood pressure monitor. You can find this device at your local pharmacy. Your doctor can tell you how to use it.

Clinical monitoring

Your doctor will monitor your health. While you take nisoldipine, your doctor will check your blood pressure and heart rate, and perform blood tests from time to time. These blood tests may check things such as your liver function.

Your diet

Your doctor may have you follow a heart-healthy diet. Talk to your doctor about which foods are good for your heart, and which ones you should avoid.

Hidden costs

You may need to buy a home blood pressure monitor to keep track of your blood pressure. Your doctor can tell you more.

Insurance

Many insurance companies require a prior authorization for this drug. This means your doctor will need to get approval from your insurance company before your insurance company will pay for the prescription.

Are there any alternatives?

There are other drugs available to treat your condition. Some may be better suited for you than others. Talk to your doctor about other drug options that may work for you.

SECTION 5 of 5

How Much Does nisoldipine Cost?

Oral tablet

We've partnered with GoodRx so you can compare prices, find discounts and save up to 80% on your next prescription. Check out the low coupon prices below — no insurance required.

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Lowest price for nisoldipine

Walgreens $75.74
Rite-Aid $81.20
CVS Pharmacy $98.61
These prices represent the lowest priced national pharmacies for nisoldipine on GoodRx. They may be lower than your insurance.

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These prices represent the lowest priced national pharmacies for nisoldipine on GoodRx. They may be lower than your insurance.

Content developed in collaboration with University of Illinois-Chicago, Drug Information Group

Medically reviewed by Creighton University, Center for Drug Information and Evidence-Based Practice on September 27, 2015

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up-to-date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
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